Panophthalmitis

Acute suppurative inflammation of the inner eye with necrosis of the sclera (and sometimes the cornea) and extension of the inflammation into the orbit. Pain may be severe and the globe may rupture. In endophthalmitis the globe does not rupture.

Also Known As:

Networked: 48 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Endophthalmitis (Ophthalmia)
2.	Infection
3.	Orbital Cellulitis
4.	Necrosis
5.	Keratitis

Experts

1.	Gupta, A: 2 articles (01/2008 - 01/2000)
2.	Rath, Suryasnata: 1 article (01/2015)
3.	Tripathy, Devjyoti: 1 article (01/2015)
4.	de la Paz, Maria Fideliz: 1 article (01/2014)
5.	Barraquer, Rafael I: 1 article (01/2014)
6.	de Rezende Couto Nascimento, Valeria: 1 article (01/2014)
7.	Prause, Jan Ulrik: 1 article (01/2014)
8.	Hitzl, Wolfgang: 1 article (01/2014)
9.	Jørgensen, Jesper Skovlund: 1 article (01/2014)
10.	Kiilgaard, Jens Folke: 1 article (01/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Panophthalmitis:

1.	Retinaldehyde (Retinal)IBA 01/01/1970 - "[Mycotic panophthalmitis following retinal surgery]." 02/15/1982 - "Other findings included retinal separation, panophthalmitis, and glaucoma. " 06/15/1993 - "Unlike cytomegalovirus retinitis, progressive outer retinal necrosis, and syphilitic retinitis, however, toxoplasmosis can cause a progressive intraocular infection, panophthalmitis, and orbital cellulitis in patients with AIDS."
2.	Anti-Bacterial Agents (Antibiotics)IBA 01/01/2010 - "Despite the culture-demonstrated sensitivity of this organism to the antibiotics given intravitreally, systemically, and topically to treat this infection, her condition deteriorated, and she developed panophthalmitis, orbital cellulitis, a corneal ulcer, and eventual no light perception vision. " 01/01/1998 - "A case of pneumonia associated with pneumococcal endocarditis of bicuspid aortic valve complicated by pneumococcal meningitis and panophthalmitis successfully treated by antibiotics and late valve replacement was described." 02/01/1953 - "Effect of sulfonamides and antibiotics on panophthalmitis complicating cataract extraction."
3.	Streptomycin (Streptomycin Sulfate)FDA Link 06/01/1947 - "Panophthalmitis in a premature infant treated by streptomycin." 06/01/1947 - "PANOPHTHALMITIS IN A PREMATURE INFANT TREATED BY STREPTOMYCIN."
4.	OxygenIBA 01/01/1976 - "The use of hyperbaric oxygen is not indicated in cases of gas gangrene panophthalmitis. " 02/01/1971 - "Gas gangrene panophthalmitis treated with hyperbaric oxygen."
5.	Amphotericin B (Amphotericin)FDA LinkGeneric 01/01/2008 - "Patients with panophthalmitis were eviscerated and rest received intravitreal amphotericin B. " 01/01/2000 - "One patient with panophthalmitis was treated with intravenous amphotericin B. "
6.	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/01/1985 - "The failure of cyclosporin to inhibit granulomatous inflammation in acute Arthus-like panophthalmitis."
7.	Fluconazole (Zonal)FDA LinkGeneric 01/01/2006 - "Severe Candida albicans panophthalmitis treated with all available and potentially effective antifungal drugs: fluconazole, liposomal amphotericin B, caspofungin, and voriconazole."
8.	Vinblastine (Vinblastine Sulfate)FDA Link 06/01/1988 - "Serious neutropenia after vinblastine-loaded platelets occurred in one patient leading to pseudomonas septicaemia and panophthalmitis with permanent vision loss of left eye. "
9.	SulfonamidesIBA 02/01/1953 - "Effect of sulfonamides and antibiotics on panophthalmitis complicating cataract extraction."
10.	Penicillins (Penicillin)FDA Link 08/01/1994 - "The affected eye became amaurotic, but the panophthalmitis was controlled by minimal surgical debridement and systemic antibiotic therapy with penicillin, fucidic acid and metronidazole. "

Therapies and Procedures

1.	Corneal Transplantation (Keratoplasty) 01/01/1992 - "Keratoplasty, done immediately, prevented panophthalmitis and cured the patient. " 02/01/2009 - "All patients had a poor visual outcome with one requiring evisceration because of panophthalmitis, whereas three underwent therapeutic keratoplasty. "
2.	Vitrectomy 04/01/1998 - "One eye was lost to panophthalmitis 11 days after the vitrectomy; the remaining 18 eyes showed a favourable outcome. " 01/01/2013 - "To describe the findings and clinical course of a case of Listeria endophthalmitis as it progressed to panophthalmitis despite vitrectomy and intravitreal and systemic antibiotic therapy. " 01/01/1999 - "Surgery in 18/19 eyes included vitrectomy with intraocular antibiotic injections for endophthalmitis (14 eyes), evisceration for panophthalmitis (2 eyes), and cataract extraction for traumatic cataract (2 eyes). "
3.	Cataract Extraction 07/15/1922 - "RECOVERY OF VISION AFTER INCIPIENT PANOPHTHALMITIS FOLLOWING CATARACT EXTRACTION." 01/01/1999 - "Surgery in 18/19 eyes included vitrectomy with intraocular antibiotic injections for endophthalmitis (14 eyes), evisceration for panophthalmitis (2 eyes), and cataract extraction for traumatic cataract (2 eyes). " 02/01/1953 - "Effect of sulfonamides and antibiotics on panophthalmitis complicating cataract extraction."
4.	Orbital Implants 01/01/2015 - "Evisceration with Primary Orbital Implant in Fulminant Endophthalmitis/Panophthalmitis." 05/01/2005 - "A prevalent conception exists that a two-stage operation (i.e., primary enucleation or evisceration with delayed secondary orbital implant insertion) is necessary when enucleation is required for recalcitrant endophthalmitis or panophthalmitis. " 01/01/2015 - "To compare the outcome of evisceration with primary orbital implant in blind eyes with and without fulminant infection (endophthalmitis/panophthalmitis). " 01/01/2015 - "Our data suggest that evisceration with primary orbital implant is a feasible option in fulminant endophthalmitis/panophthalmitis and provides a good postoperative cosmetic outcome to the anophthalmic socket at an economical cost."
5.	Penetrating Keratoplasty 01/01/1989 - "Panophthalmitis after penetrating keratoplasty. " 09/01/2012 - "Despite vigorous topical and systemic antibacterial therapy, and immediate therapeutic penetrating keratoplasty, the infection progressed to panophthalmitis and required evisceration on the fifth day. "