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Pancuronium (Pavulon)

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A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than CURARE but has less effect on the circulatory system and on histamine release.

Also Known As:

Pavulon; Organon Brand of Pancuronium Bromide; Organon Teknika Brand of Pancuronium Bromide; Pancuronium Bromide; Pancuronium Curamed; Pancuronium Organon; Schwabe Brand of Pancuronium Bromide; Bromide, Pancuronium; Piperidinium, 1,1'-((2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)androstane-2,16-diyl)bis(1-methyl-)

Networked: 450 relevant articles (15 outcomes, 25 trials/studies)

Relationship Network

Drug Context: Research Results

Polycyclic Compounds: 56
- Steroids: 18537
  - Androstanes: 8
    - Androstanols
      - Pancuronium: 450
        Org 6368: 2
        (dideacetoxy)pancuronium
        17-(monodesacetyl)pancuronium
        2,16-dipiperidinoandrostane-3,17-diol dipivalate
        3 alpha,17 beta-dibutyryloxy-2 beta,16 beta-dipiperidino-5 alpha-androstane dimethobromide
        3-(deacetoxy)pancuronium
        3-desacetylpancuronium
        dacuronium

Experts

1.	Pitsillides, Andrew A: 2 articles (04/2006 - 08/2003)
2.	Cools, F: 2 articles (01/2005 - 01/2000)
3.	Offringa, M: 2 articles (01/2005 - 01/2000)
4.	Szokol, Joseph W: 2 articles (01/2004 - 05/2003)
5.	Avram, Michael J: 2 articles (01/2004 - 05/2003)
6.	Vender, Jeffery S: 2 articles (01/2004 - 05/2003)
7.	Murphy, Glenn S: 2 articles (01/2004 - 05/2003)
8.	Marymont, Jesse H: 2 articles (01/2004 - 05/2003)
9.	Sugumar, Bina: 1 article (01/2016)
10.	Cappello, Paola: 1 article (01/2016)

Related Diseases

1.	Paralysis (Palsy) 09/30/1976 - "The half-life of the beta-phase varied between 89.5 and 161.5 min. The apparent volume of distribution of the central compartment ranged from 62.9 to145.5 ml/kg and the plasma clearance from 57.6 to 187.3 ml/min. At the first sign of recovery from neuro-muscular blockade the mean pancuronium plasma level was found to be 0.218 mcg/ml. The mean duration of action as measured from time of onset of paralysis to 20% recovery was 83.4 min with the plasma level at 20% being 0.169 mcg/ml corresponding to 45.4% of dose remaining to be eliminated from the body." 07/01/1995 - "To study the effects of muscle paralysis on joint mobility, we compared eight premature infants treated with pancuronium bromide with a control group. " 05/01/1985 - "We conclude that 1) although tonic inspiratory activity of chest wall muscles exists, it does not significantly affect the chest wall relaxation characteristics in trained subjects; 2) submaximal paralysis produced by pancuronium bromide is likely to modify either spinal attitude or the distribution of blood between extremities and the thorax; these effects may account for the changes in FRC in other studies." 12/01/1984 - "The purpose of this study was to evaluate cerebral blood flow and metabolism following pancuronium bromide paralysis in healthy newborn lambs. " 07/01/2011 - "We found that pancuronium-induced paralysis did not affect the electrophysiological properties of ongoing cortical activity and its perturbation evoked by visual and tactile stimuli. "
2.	Bradycardia 01/01/1994 - "Pancuronium offered protection against bradyarrhythmias." 10/01/1991 - "The administration of pancuronium reduced the incidence of bradycardia in appropriately grown fetuses (6% to 1.5%; p less than 0.05), but did not alter the incidence in growth-retarded fetuses. " 11/01/1977 - "Bradycardia during antagonism of pancuronium-induced neuromuscular block." 02/01/1987 - "The incidence of bradycardia or bradydysrhythmias was higher in the group having vecuronium compared with those given pancuronium. " 01/01/1980 - "Pipecurium bromide did not influence blood pressure but in contrast to the heart rate increasing effect of pancuronium bromide, it caused mild bradycardia. "
3.	Anoxia (Hypoxia) 04/01/1993 - "This study was designed to determine the hemodynamic effects of pancuronium administered under conditions of normoxia, hypoxia, and preexposure to hypoxia in neonatal piglets with normal lungs. " 04/01/1993 - "In conclusion, pancuronium administered during normoxia, hypoxia, or after preexposure to hypoxia while controlled ventilation is maintained does not alter systemic or pulmonary hemodynamic status of the newborn piglet." 04/01/1993 - "Pancuronium does not alter the hemodynamic status of piglets after normoxia or hypoxia." 01/01/2000 - "We conclude that PORP after pancuronium is a significant risk factor for hypoxemia." 11/01/1987 - "Fifty-one awake cats immobilized with pancuronium bromide were divided into 4 groups: group I, control; group II, normocapnic hypoxia (PaO2 = 50 mmHg); group III, normoxic hypercapnia (Pa-CO2 = 70 mmHg), and group IV, increased intracranial pressure (ICP = 40 mmHg) by brain compression. "
4.	Renal Insufficiency (Renal Failure) 04/01/1976 - "With this model, the clearance of pancuronium was found to be reduced significantly in the patients with renal failure, and in these individuals the volume of the central (distribution) compartment was increased significantly. " 01/01/1978 - "Objective studies about the duration of action pancuronium (PCM) in renal failure patients are scarce. " 09/01/1996 - "They suggest pancuronium as the drug of choice if the patient does not have renal insufficiency and is hemodynamically stable. " 11/01/1987 - "Pancuronium and renal failure." 01/01/1982 - "Antagonism of pancuronium in renal failure: no recurarization."
5.	Seizures (Seizure) 06/01/1992 - "Effects of pancuronium bromide on cerebral blood flow changes during seizures in newborn pigs." 01/01/1989 - "Given as an adjunct treatment, in case of seizures, pancuronium has no significant effect on changes in cerebral haemodynamics. " 05/01/1982 - "Nine infants who were mechanically ventilated and paralyzed with pancuronium had their condition diagnosed as seizure activity. " 06/01/1992 - "These data suggest that pancuronium limits cerebral hyperemia during prolonged seizures by attenuating increases in blood pressure as a result of elimination of skeletal muscle activity. " 05/01/1994 - "Pancuronium and vecuronium caused sustained increases in [Ca2+]i in approximately the same potency ratio as for seizure activity in vivo (concentrations at which the increase in [Ca2+]i was 95% of maximal: 100 and 400 microM, respectively). "

Related Drugs and Biologics

1.	Succinylcholine (Suxamethonium Chloride)
2.	Midazolam (Versed)
3.	Fentanyl (Sublimaze)
4.	Atracurium (Tracrium)
5.	Halothane (Fluothane)
6.	Neostigmine (Neostigmine Bromide)
7.	metocurine (Metubine)
8.	Atropine (Hyoscyamine)
9.	Alcuronium (Alcuronium Chloride)
10.	Propofol (Diprivan)

Related Therapies and Procedures

1.	Artificial Respiration (Mechanical Ventilation)
2.	Anesthesia
3.	Ligation
4.	Tracheostomy
5.	Electrodes (Electrode)