Pancreatic Polypeptide (Pancreatic Polypeptide (PP))

A 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the ISLETS OF LANGERHANS and adjacent to cells containing SOMATOSTATIN and GLUCAGON. Pancreatic polypeptide (PP), when administered peripherally, can suppress gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite. A lack of pancreatic polypeptide (PP) has been associated with OBESITY in rats and mice.

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Networked: 680 relevant articles (6 outcomes, 53 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Davis, Stephen N: 5 articles (01/2015 - 07/2004)
2.	Cryer, Philip E: 5 articles (04/2004 - 04/2002)
3.	Davis, S N: 5 articles (06/2001 - 01/2000)
4.	Bloom, Stephen R: 4 articles (12/2011 - 01/2008)
5.	Banarer, Salomon: 4 articles (05/2003 - 04/2002)
6.	Tate, D: 4 articles (06/2001 - 01/2000)
7.	Sainsbury, Amanda: 3 articles (12/2015 - 05/2002)
8.	Ertl, Andrew C: 3 articles (04/2010 - 07/2004)
9.	Tate, Donna B: 3 articles (04/2010 - 09/2008)
10.	McGregor, Veronica P: 3 articles (05/2002 - 04/2002)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2008 - "The relationship between tumor location considering the embryological structure of the pancreas and the site of PLX invasion was investigated with an immunohistochemical study using pancreatic polypeptide. " 06/01/2009 - "Pancreatic polypeptide (PP) is expressed in pancreatic islets and is known to be expressed in pancreatic endocrine tumors. " 08/01/2008 - "Their diagnosis was established by the presence of an enhancing solitary pancreatic tumor on computed tomography (CT) and elevated fasting pancreatic polypeptide hormone levels. " 08/01/2008 - "Sporadic pancreatic polypeptide secreting tumors (PPomas) of the pancreas." 01/01/2008 - "Final pathology documented a pancreatic endocrine tumor with immunohistochemical staining demonstrating the presence of pancreatic polypeptide. "
2.	Chronic Pancreatitis 01/01/1994 - "The purpose of this study was to investigate interdigestive cycling and postprandial release of pancreatic polypeptide (PP) in relation to exocrine pancreatic function in chronic pancreatitis (CP). " 02/01/2002 - "In both acute and chronic pancreatitis, changes in plasma concentration of pancreatic polypeptide (PP) and its regulation have been reported. " 01/01/2001 - "Pancreatic polypeptide secretion in patients with chronic pancreatitis and after pancreatic surgery." 10/01/1996 - "Chronic pancreatitis (CP) is associated with lowered plasma levels and a blunted nutrient-induced release of pancreatic polypeptide (PP). " 04/01/1993 - "No data, however, favour the view that absent pancreatic polypeptide secretion has any major effect on the glucoregulation in diabetes secondary to chronic pancreatitis. "
3.	Ganglion Cysts (Ganglion) 01/01/1982 - "Pancreatic polypeptide appears to be relayed from its cells of origin to a neurohaemal organ in the dorsal sheath of the thoracic ganglion. " 01/01/1993 - "FMRFamide and bovine pancreatic polypeptide (BPP) immunoreactivities were detected in the cerebral ganglion and in the alimentary tract of the protochordate ascidian Styela plicata. " 12/02/1985 - "Distinct localization of FMRFamide- and bovine pancreatic polypeptide-like material in the brain, retrocerebral complex and suboesophageal ganglion of the cockroach Periplaneta americana L." 01/01/1982 - "Prolactin-immunoreactive and pancreatic polypeptide-immunoreactive cells were argyrophilic with the Grimelius' stain and were found in neighbouring positions in the cerebral ganglion. " 06/15/1989 - "Immunohistochemical staining for neuron-specific enolase (NSE), neurofilament (NF), pancreatic polypeptide, and somatostatin showed positive results for epithelioid and ganglion-like cells, whereas spindle cells showed immunoreactivities for S-100 protein, NSE, and NF. "
4.	Multiple Endocrine Neoplasia (Multiple Endocrine Adenomatosis) 02/05/1982 - "Multiple endocrine adenomatosis type I. Occurrence in an octogenarian with high levels of circulating pancreatic polypeptide." 12/01/1983 - "Pancreatic polypeptide update: its roles in detection of the trait for multiple endocrine adenopathy syndrome, type I and pancreatic polypeptide-secreting tumors." 08/01/1981 - "An apparently complete remission of metastases in the liver from a resected pure pancreatic polypeptide apudoma occurred following intra-arterial and intravenous administration of streptozocin to a patient in a family with multiple endocrine adenopathy, type 1. Plasma concentrations of human pancreatic polypeptide constitute an excellent marker system for the detection and assessment of tumor status before and after surgical and streptozocin therapy." 01/01/1980 - "Elevated basal and responsive (after a meal) plasma concentrations of a relatively new candidate-hormone, human pancreatic polypeptide (hPP), were associated with pancreatic apudoma tumors in three asymptomatic patients with multiple endocrine adenopathies, type I. Two of these patients had excision of the tumors that resulted in normal plasma hPP concentrations postoperatively. " 06/01/2002 - "Ten cases of normal pancreatic tissue, two cases of nesidioblastosis, five insulin-producing tumours and one case of multiple endocrine neoplasia 1 syndrome, containing an insulin-, a somatostatin- and several glucagon-producing tumours, as well as tiny foci of endocrine dysplasia with different predominance of the secreted hormones (mainly glucagon and pancreatic polypeptide) were included in the study. "
5.	Body Weight (Weight, Body) 02/01/2007 - "A role for pancreatic polypeptide in feeding and body weight regulation." 05/01/2002 - "Y4(-/-) mice displayed lower body weight and reduced white adipose tissue mass accompanied by increased plasma levels of pancreatic polypeptide (PP). " 12/01/1999 - "Decreased food intake and body weight in pancreatic polypeptide-overexpressing mice." 07/15/1977 - "Administration of bovine pancreatic polypeptide (bPP) reduces food intake and suppresses body weight gain in the hyperphagic obese mice. " 03/03/2010 - "The hormone, pancreatic polypeptide (PP) is postulated to be involved in body weight regulation. "

Related Drugs and Biologics

1.	Insulin (Novolin)
2.	Somatostatin (Somatotropin Release-Inhibiting Factor)
3.	Phosphopyruvate Hydratase (Enolase)
4.	Glucose (Dextrose)
5.	Blood Glucose (Blood Sugar)
6.	S100 Proteins (S 100 Protein)
7.	Streptozocin (Streptozotocin)
8.	Glucagon (Glukagon)
9.	Gastrins
10.	Hormones

Related Therapies and Procedures

1.	Subcutaneous Infusions
2.	Intravenous Injections
3.	Electroacupuncture
4.	Truncal Vagotomy
5.	Vagotomy