Pactamycin

Antibiotic produced by Streptomyces pactum used as an antineoplastic agent. It is also used as a tool in biochemistry because it inhibits certain steps in protein synthesis.

Also Known As:

Benzoic acid, 2-hydroxy-6-methyl-, (5-((3-acetylphenyl)amino)-4-amino-3-(((dimethylamino)carbonyl)amino)-1,2-dihydroxy-3-(1-hydroxyethyl)-2-methylcyclopentyl)methyl ester, (1S-(1alpha,2beta,3alpha,3(R*),4alpha,5beta))-

Networked: 9 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Gerstner, Nels C: 1 article (01/2021)
2.	Nicastri, Kate A: 1 article (01/2021)
3.	Schomaker, Jennifer M: 1 article (01/2021)
4.	Ganguli-Indra, Gitali: 1 article (01/2015)
5.	Guha, Gunjan: 1 article (01/2015)
6.	Indra, Arup Kumar: 1 article (01/2015)
7.	Kulesz-Martin, Molly F: 1 article (01/2015)
8.	Li, Shan: 1 article (01/2015)
9.	Liang, Xiaobo: 1 article (01/2015)
10.	Lu, Wanli: 1 article (01/2015)

Related Diseases

1.	Amnesia (Dissociative Amnesia) 01/01/1977 - "Protein synthesis and amnesia: studies with emetine and pactamycin." 01/01/1977 - "Anisomycin and cycloheximide caused amnesia in a passive avoidance task, whereas pactamycin and emetine did not. " 01/01/1977 - "Two antibiotic inhibitors of protein synthesis, emetine and pactamycin, have been tested for their effects on cerebral and peripheral protein synthesis and amnesia. "
2.	Squamous Cell Carcinoma of Head and Neck 01/01/2015 - "In this study, we characterized the effects of two novel biosynthetically engineered analogs of pactamycin, de-6MSA-7-demethyl-7-deoxypactamycin (TM-025) and 7-demethyl-7-deoxypactamycin (TM-026), in head and neck squamous cell carcinoma (HNSCC) cell lines SCC25 and SCC104. " 01/01/2015 - "Novel Pactamycin Analogs Induce p53 Dependent Cell-Cycle Arrest at S-Phase in Human Head and Neck Squamous Cell Carcinoma (HNSCC) Cells." 01/01/2015 - "Altogether, our results demonstrate that Pactamycin analogs TM-025 and TM-026 induce senescence and inhibit proliferation of HNSCC cells via accumulation in S-phase through possible contribution of p53. "
3.	Mastocytoma 09/01/1974 - "Pactamycin and emetine, in doses of 10(-7) M to 10(-6) M, suppressed production of MIF and LT with only slight effect on killing of mastocytoma cells by immune T cells. "
4.	African Trypanosomiasis (Nagana) 01/01/2021 - "Pactamycin and its derivatives bind to the 30S ribosomal subunit and display activity against parasites responsible for drug-resistant malaria and African sleeping sickness; however, efforts to develop their therapeutic potential have been hampered by their cellular toxicity. "
5.	Poliomyelitis (Polio) 12/01/1995 - "Protein synthesis inhibitors with different mechanism of action (anisomysin, cycloheximide, emetine, pactamycin, puromycin, and polio virus) all reversed the down-regulatory response. "

Related Drugs and Biologics

1.	Emetine
2.	Proteins (Proteins, Gene)
3.	Cycloheximide (Cicloheximide)
4.	Anti-Bacterial Agents (Antibiotics)
5.	Puromycin
6.	Protein Synthesis Inhibitors
7.	Peptides (Polypeptides)
8.	Leucine (L-Leucine)
9.	Interleukin-2 (IL2)
10.	Anisomycin