p-Aminohippuric Acid (p-Aminohippurate)

The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity.
Also Known As:
p-Aminohippurate; Aminohippurate Sodium; Aminohippuric Acid; Nephrotest; Sodium Para-Aminohippurate; 4 Aminohippuric Acid; Para-Aminohippurate, Sodium; Sodium Para Aminohippurate; Sodium, Aminohippurate; p Aminohippurate; p Aminohippuric Acid; para Aminohippuric Acid; 4-Aminohippuric Acid; para-Aminohippuric Acid; Glycine, N-(4-aminobenzoyl)-
Networked: 119 relevant articles (17 outcomes, 13 trials/studies)

Relationship Network

Drug Context: Research Results


1. Brandoni, Anabel: 2 articles (05/2009 - 01/2008)
2. Gutberlet, Marcel: 1 article (01/2014)
3. Meier, Martin: 1 article (01/2014)
4. Mengel, Michael: 1 article (01/2014)
5. Wacker, Frank: 1 article (01/2014)
6. Gueler, Faikah: 1 article (01/2014)
7. Hartung, Dagmar: 1 article (01/2014)
8. Rong, Song: 1 article (01/2014)
9. Hueper, Katja: 1 article (01/2014)
10. Lu, Xia: 1 article (01/2014)

Related Diseases

1. Hypertension (High Blood Pressure)
03/01/1947 - "Renal extraction of p-aminohippurate in normal subjects and in essential hypertension and chronic diffuse glomerulonephritis."
05/09/1991 - "We compared renal hemodynamics, measured in terms of the clearance of para-aminohippuric acid and inulin, and the characteristics of the renin-angiotensin-aldosterone system in three groups of normotensive subjects at different degrees of risk for hypertension: 41 subjects with two normotensive parents, 52 with one normotensive and one hypertensive parent, and 61 with two hypertensive parents. "
09/01/1997 - "To investigate changes in systemic and regional hemodynamics during the development of human hypertension, we simultaneously measured cardiac index (CI) by the indocyanine green (ICG) dye dilution method, hepatosplanchnic blood flow (HBF) by the ICG clearance method using a two-compartment model, and renal blood flow (RBF) by the p-aminohippurate clearance method in patients with borderline and essential hypertension. "
07/01/1982 - "To test these hypotheses, techniques for the clearance of inulin (Cin) and p-aminohippurate (Cpah) were used to assess renal function and hemodynamic measurements in patients with mild and moderate normal-renin and low-renin essential hypertension and in age-matched normotensive subjects. "
01/01/2002 - "Normotensive young men (25 +/- 2 years) with positive family history (PFH) (n = 28) and negative family history (NFH) (n = 60) of arterial hypertension were investigated to study aldosterone response, and systemic and renal haemodynamic changes (p-aminohippurate- and inulin-clearance) to Ang II infusion (0.5 and 3.0 ng/min per kg). "
2. Body Weight (Weight, Body)
01/01/1978 - "Tubular secretory capacity has been investigated in the kidney of marine fishes Scorpaena porcus, Spicara smaris, frog Rana ridibunda and albino rat by determination of maximal transport of p-aminohippurate--TmPAH, Following values of Tmax expressed in mg/hour per 100 g of body weight were obtained: 0.73 +/- 0.17 for S. "
10/01/1988 - "A pressor response was observed in the latter at a dose of 10 pmol h-1 (100 g body weight)-1. 3. Pressor doses of vasopressin of 100 pmol h-1 (100 g body weight)-1 and less did not significantly alter the clearance of p-aminohippurate (PAH) in either conscious or anaesthetized rats. "
02/01/1988 - "Para-aminohippuric acid (PAHA, 0.1 mg/min/kg of body weight) was infused IV into 2 mares, followed by concurrent IV infusion of PAHA and probenecid (0.075, 0.15, 0.25, or 0.35 mg of probenecid/min/kg). "
03/01/2010 - "Barrows (n 6; aged 35 d; weight 8.6 kg), implanted with arterial, portal, mesenteric and gastric catheters, were fed a diet containing dl-methionine (dl-MET) or dl-HMTB once hourly and infused intramesenterically with 1 % p-aminohippurate and intragastrically with [1-13C]methionine at 7.0 mumol/kg body weight per h. "
01/01/1984 - "Sham-operated (SO) rats cleared inulin and p-aminohippurate (PAH) at rates of 3.84 and 7.49 ml/min, respectively, while compensated PN rats cleared inulin at 2.51 and PAH at 8.84 ml/min. Daily administration of low levels of OA produced decreased urine osmolality and body weight with a modest increase in urinary protein of PN versus SO rats. "
3. Bacteremia
4. Cicatrix (Scar)
5. Necrosis

Related Drugs and Biologics

1. Inulin
2. Creatinine
3. Sodium
4. Nitric Oxide (Nitrogen Monoxide)
5. Urea (Carbamide)
6. Tetraethylammonium (Tetraethylammonium Bromide)
7. Tea
8. Renin
9. Potassium
10. Insulin (Novolin)

Related Therapies and Procedures

1. Lasers (Laser)
2. Surgical Instruments (Clip)
3. Catheters
4. Homologous Transplantation (Allograft)
5. Resuscitation