Ozone

The unstable triatomic form of oxygen, O3. It is a powerful oxidant that is produced for various chemical and industrial uses. Its production is also catalyzed in the ATMOSPHERE by ULTRAVIOLET RAY irradiation of oxygen or other ozone precursors such as VOLATILE ORGANIC COMPOUNDS and NITROGEN OXIDES. About 90% of the ozone in the atmosphere exists in the stratosphere (STRATOSPHERIC OZONE).

Also Known As:

Networked: 4042 relevant articles (266 outcomes, 852 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kodavanti, Urmila P: 39 articles (01/2022 - 03/2011)
2.	Shore, Stephanie A: 35 articles (01/2021 - 03/2003)
3.	Schladweiler, Mette C: 29 articles (01/2022 - 03/2011)
4.	Snow, Samantha J: 27 articles (01/2022 - 07/2015)
5.	Harkema, Jack R: 25 articles (11/2022 - 01/2002)
6.	Chung, Kian Fan: 25 articles (03/2022 - 07/2007)
7.	Li, Feng: 20 articles (01/2022 - 05/2011)
8.	Kasahara, David I: 20 articles (10/2020 - 11/2009)
9.	Zhang, Min: 19 articles (06/2022 - 05/2011)
10.	Peden, David B: 19 articles (04/2022 - 08/2002)

Related Diseases

1.	Pain (Aches) 02/03/2021 - "In 2 months follow up, significant improvement of pain, stiffness, and function were seen in all groups compared to the baseline, but the ozone group had the best results (P < 0.05). " 01/01/2022 - "There was a statistically significant improvement in pain intensity and functional disability 2 weeks after intervention in the three groups, but at 1-month and 3-months after intervention, the significant improvement was in Mg sulphate and Ozone groups only. " 09/01/2020 - "All patients experienced significant improvement of sign and pain scores with a higher rate of improvement in ozone-treated group (T1 improvement rates: Thongprasom 92.2% vs 28%; VAS pain 76.9% vs 32%; p<0.05). " 09/01/2017 - "In the ozone group, three weeks after intervention, the pain score improved significantly when compared with the control group (p<0.05).After the treatment, the lysholm scores increased significantly (p<0.05), but in the ozone group, it improved faster. " 12/01/2002 - "While patients perceived the ozone treatment to be beneficial in terms of pain relief, it was impossible to isolate the impact of ozone alone as other preparations and treatments were also being given. "
2.	Inflammation (Inflammations) 05/01/2005 - "To determine whether ozone exposure induces greater oxidative stress and airway inflammation in RAO-affected horses in remission than in healthy horses. " 01/01/2018 - "Moreover, ozone treatment suppressed inflammation and helped maintain metabolic balance in chondrocytes stimulated with IL-1β." 11/01/2017 - "The patient undergoing fixed orthodontic treatment showed a consistent improvement in gingival inflammation on frequent irrigation with ozone jet irrigation as compared with saline irrigation delivered with same jetting force." 07/01/2022 - "This study investigated the role and mechanism of the TRPA1/TRPV1 pathway in airway inflammation and bronchial hyperresponsiveness (BHR) induced by acute ozone exposure. " 11/05/2021 - "Our study found that even short-term exposure to low concentrations of ozone was associated with inflammation, lipid peroxidation, and mitochondrial oxidative damage. "
3.	Intervertebral Disc Displacement (Herniated Disc) 02/01/2019 - "Based on our findings it seems that MSU classification can be used in patients' selection to achieve the best treatment outcome after intradiscal ozone injection among patients with lumbar disc herniation." 01/01/2014 - "We conclude that ozone is safe and effective in approximately 75% of patients with disc herniation and the benefit is maintained through ten years. " 03/28/2010 - "Percutaneous intradiscal ozone injection via the posterior-lateral route and inner margin of the facet joint is effective and safe for treatment of large lumbar disc herniation." 11/01/2018 - "Our study's aim is to evaluate prospectively the efficacy of ozone nucleolysis in the treatment of either contained or uncontained lumbar disc herniations. " 01/01/2018 - "This retrospective study compared the efficacy of combined percutaneous ozone injection and percutaneous discectomyto percutaneous ozone injection alone for the treatment of cervical disc herniation. "
4.	COVID-19 01/01/2021 - "Preliminary results, although not showing statistically significant benefits of ozone on COVID-19, did not report any toxicity." 01/01/2022 - "In conclusion, through careful choice of (CT, RH), gaseous ozone is effective against SARS-CoV-2 and our results are of significance to a growing field where ozone is applied to control the spread of COVID-19." 10/01/2023 - "Ozone Efficacy for the Disinfection of Ambulances Used to Transport Patients during the COVID-19 Pandemic in Peru." 03/01/2023 - "This systematic review and meta-analysis aimed to determine the efficacy of ozone on mortality in patients with COVID-19. " 03/01/2021 - "With the implementation of COVID-19 restrictions and consequent improvement in air quality due to the nationwide lockdown, ozone (O3) pollution was generally amplified in China. "
5.	Knee Osteoarthritis 01/01/2019 - "[Efficacy of Ozone Infiltrations in the Treatment of Knee Osteoarthritis Vs Other Interventional Treatments: A Systematic Review of Clinical Trials]." 01/01/2019 - "Only randomized-controlled trials that assessed the efficacy of intraarticular or periarticular infiltrations with ozone to treat knee osteoarthritis in humans were included in the analysis. " 01/01/2019 - "To evaluate the safety and efficacy of intra-articular ozone infiltrations in patients with knee osteoarthritis. " 01/01/2019 - "Efficacy of combined ozone and platelet-rich-plasma treatment versus platelet-rich-plasma treatment alone in early stage knee osteoarthritis." 01/01/2018 - "An investigation into the efficacy of intra-articular ozone (O2-O3) injection in patients with knee osteoarthritis: a systematic review and meta-analysis."

Related Drugs and Biologics

1.	Oxygen (Dioxygen)
2.	Antioxidants
3.	Steroids
4.	Hyaluronic Acid (Hyaluronan)
5.	Lidocaine (Xylocaine)
6.	Air Pollutants (Pollutants, Air)
7.	Cytokines
8.	Adrenal Cortex Hormones (Corticosteroids)
9.	Anti-Bacterial Agents (Antibiotics)
10.	Disinfectants (Biocides)

Related Therapies and Procedures

1.	Therapeutics
2.	Injections
3.	Intra-Articular Injections
4.	Hyperbaric Oxygenation
5.	Root Planing