Ozone

An unstable triatomic form of oxygen, O3, that exists in the atmosphere in varying proportions. It is produced continuously in the outer layers of the atmosphere by the action of solar UV-radiation on the oxygen of the air.

Networked: 2090 relevant articles (86 outcomes, 330 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Shore, Stephanie A: 21 articles (10/2015 - 03/2003)
2.	Peden, David B: 14 articles (03/2015 - 08/2002)
3.	Laskin, Debra L: 13 articles (04/2015 - 04/2002)
4.	Johnston, Richard A: 12 articles (11/2015 - 03/2003)
5.	Chung, Kian Fan: 12 articles (09/2015 - 07/2007)
6.	Kleeberger, Steven R: 12 articles (08/2015 - 10/2004)
7.	Laskin, Jeffrey D: 12 articles (04/2015 - 04/2002)
8.	Floros, Joanna: 12 articles (10/2014 - 01/2002)
9.	Schwartz, Joel: 12 articles (01/2013 - 02/2002)
10.	Diaz-Sanchez, David: 11 articles (04/2015 - 03/2009)

Related Diseases

1.	Inflammation 05/01/2005 - "To determine whether ozone exposure induces greater oxidative stress and airway inflammation in RAO-affected horses in remission than in healthy horses. " 03/01/2015 - "In this study, we discussed the inflammation and oxidative stress responses of rat lung caused by ozone and PM2.5 versus that of rats exposed to saline, ozone, or single PM2.5 . " 03/01/2014 - "In the present study, we investigated the acute and chronic effects of ozone exposure-induced oxidative stress-related inflammation mechanics in mouse lung. " 07/03/2012 - "This controlled-human-exposure study shows that ozone can cause an increase in vascular markers of inflammation and changes in markers of fibrinolysis and markers that affect autonomic control of heart rate and repolarization. " 01/01/2011 - "Our study suggests that acute ozone-induced airway inflammation does not increase resting sympathetic nerve traffic in healthy subjects, an observation that is relevant for environmental health. "
2.	Infection 09/01/2011 - "Plant-derived phenylpropanoids (PPPs) compose the largest group of secondary metabolites produced by higher plants, mainly, for the protection against biotic or abiotic stresses such as infections, wounding, UV irradiation, exposure to ozone, pollutants, and herbivores. " 09/01/1998 - "Ad libitum-fed rats exposed to ozone and challenged with Streptococcus zooepidemicus experienced a prolonged infection and influx of polymorphonuclear leukocytes (PMN), whereas calorie-restricted rats exposed to ozone cleared the bacteria in 24 h without an inflammatory response. " 07/01/1988 - "This increased severity of the lesions after ozone exposure and subsequent infection with Listeria was presumably not a result of additive ozone and Listeria-induced lesions, but rather an effect of ozone-induced impaired clearance of the bacteria, caused by depressed macrophage activity and cellular immunity. " 04/01/2010 - "In 2006, a controlled infection study was performed in the 'Kranzberger Forst' to address the following questions: (1) Will massive artificial inoculation with Apiognomonia errabunda override the previously observed inhibitory effect of chronic ozone? " 11/23/2004 - "shasta infections no longer result in high mortality at this facility, results of this study indicate that the parasite remains a contributor to low condition indices in these fish, despite their genetic resistance and ozone disinfection of the water supply."
3.	Pain (Aches) 12/01/2002 - "While patients perceived the ozone treatment to be beneficial in terms of pain relief, it was impossible to isolate the impact of ozone alone as other preparations and treatments were also being given. " 01/01/2015 - "Studies performed during the last two decades allow the drawing of a comprehensive framework for understanding and recommending the integration of ozone therapy for spinal pain. " 01/01/2015 - "Pain pathways and control systems of algesic signals after ozone administration are described. " 01/01/2015 - "The usefulness of ozone treatment in spinal pain." 01/01/2014 - "For those who received medication, the mean MMO during the pretreatment period was 46.30 mm, and at the end of 1 week it was 46.9 mm. In the ozone group, 29% of patients showed a gradual decrease in their VAS pain scores compared to pretreatment values (6.3 ± 2.1 to 3.0 ± 2.2). "
4.	Lung Injury 09/01/2013 - "In conclusion, ozone oxidative preconditioning, repeated low-dose intraperitoneal administration of ozone, did not exacerbate radiation-induced lung injury, and, on the contrary, it provided protection against radiation-induced lung damage. " 12/01/1999 - "Neutrophils enhance clearance of necrotic epithelial cells in ozone-induced lung injury in rhesus monkeys." 09/01/2013 - "As inhalation of ozone induces lung injury, the aim of this study was to examine whether ozone oxidative preconditioning potentiates or attenuates the effects of irradiation on the lung. " 01/01/2011 - "Further studies are needed to understand how the AMPK pathway may provide a novel approach for the prevention of ozone-induced lung injury." 02/01/2006 - "Numerous studies have shown the association between ozone exposure with pulmonary injuries. "
5.	Asthma (Bronchial Asthma) 02/15/2015 - "In rhesus macaques, previous studies have shown that episodic exposure to allergen alone or combined with ozone inhalation during the first 6 months of life results in a condition with many of the hallmarks of asthma. " 01/01/2015 - "Boys exhibited a more prompt response (lag day 1) to ozone than did girls (lag day 3), but significant associations for girls were retained longer, through lag day 6. Our study indicates significant variance in associations between short-term ozone concentrations and asthma events by child sex and age. " 01/01/2015 - "This study evaluates associations between ozone exposure and asthma emergency department visits and hospitalizations among boys and girls aged 5-17 years in New York City for the 2005-2011 warm season period. " 08/01/2014 - "As part of a panel observational study, we hypothesized that systemic antioxidant ability and antioxidant status may be associated with more stable asthma during high ozone season. " 07/01/2014 - "Time-stratified case-crossover design was used to study the transient impact of ozone, PM2.5 and pollen on the acute onset of pediatric asthma. "

Related Drugs and Biologics

1.	Oxygen
2.	Reactive Oxygen Species (Oxygen Radicals)
3.	Nitrogen Dioxide
4.	Air Pollutants (Pollutants, Air)
5.	Atrial Natriuretic Factor (ANF)
6.	Enzymes
7.	Superoxide Dismutase
8.	Vitamins
9.	Cytokines
10.	Interleukin-6 (Interleukin 6)

Related Therapies and Procedures

1.	Intervertebral Disk Chemolysis (Discolysis)
2.	Injections
3.	Radiotherapy
4.	Lasers (Laser)
5.	Percutaneous Diskectomy