Oxytocics

Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157)

Also Known As:

Oxytocic Agents; Oxytocic Drugs; Oxytocic Effect; Oxytocic Effects; Agent, Oxytocic; Agents, Oxytocic; Drug, Oxytocic; Drugs, Oxytocic; Effect, Oxytocic; Effects, Oxytocic; Stimulant, Uterine; Stimulants, Uterine; Oxytocic; Oxytocic Agent; Oxytocic Drug; Uterine Stimulant; Uterine Stimulants

Networked: 176 relevant articles (9 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Therapeutic Uses: 47080
    - Reproductive Control Agents
      - Oxytocics: 176
  - Physiological Effects of Drugs: 1
    - Reproductive Control Agents
      - Oxytocics: 176

Experts

1.	Hofmeyr, G Justus: 2 articles (01/2018 - 10/2016)
2.	Baskett, Thomas F: 2 articles (09/2004 - 03/2003)
3.	Albazee, Ebraheem: 1 article (05/2022)
4.	Baradwan, Saeed: 1 article (05/2022)
5.	Elrashedy, Asmaa Ahmed: 1 article (05/2022)
6.	Faraag, Esraa: 1 article (05/2022)
7.	Samy, Ahmed: 1 article (05/2022)
8.	Samy, Zeinab: 1 article (05/2022)
9.	Sayad, Reem: 1 article (05/2022)
10.	Hasan, M R: 1 article (07/2019)

Related Diseases

1.	Postpartum Hemorrhage 07/01/1994 - "For women in developing countries where parenteral oxytocics are not available, nipple stimulation might reduce the incidence of postpartum hemorrhage. " 03/01/1985 - "Following delivery, the physician should be on the lookout for postpartum hemorrhage, which may necessitate immediate transfusion, the administration of oxytocics, and/or uterine manipulation. " 11/01/1952 - "A management of postpartum hemorrhage by prolonged administration of oxytocics." 03/01/1997 - "Immediate postpartum hemorrhage due to uterine inertia is usually treated by injection of oxytocics. " 01/01/2006 - "Oral misoprostol is as effective as conventional oxytocic agents in preventing postpartum hemorrhage and can be recommended for use in low-resource settings."
2.	Hemorrhage 10/01/1998 - "The early active management of excessive bleeding with conventional oxytocic agents may have reduced the potential of the study to detect differences between the groups." 01/01/1985 - "The study did not, therefore, confirm the reputation of oxytocic drugs in reducing the bleeding. " 02/01/2002 - "Secondary outcome measures (excessive third stage bleeding, duration of third stage of labour, need for manual removal of the placenta or the need for additional oxytocics) did not differ between the two groups. " 12/01/2001 - "Oxytocics administered after the 2nd stage of labor compared with after the 3rd stage of labor (placental expulsion) are associated with a significantly fewer rate of postpartum bleeding." 10/01/1998 - "Any excessive bleeding was actively managed with conventional oxytocic agents. "
3.	Rupture 12/01/2006 - "Obstructed labor was the common antecedent factor in the unscarred group (46.5%) and use of oxytocics accounted for maximum ruptures (44%) in the scarred category. " 05/30/1992 - "Health workers intervened (eg, artificial rupture of the membranes, administration of oxytocics) in half the dystocic cases. " 03/01/1990 - "The technique used consisted in the combination of oxytocics and rupture of the membranes. " 01/01/1990 - "Neither the position of the patient, rupture of the membranes, epidural anaesthesia, oxytocics, Dextrofemine, nor the length of labour, change the placental resistance levels during the delivery. " 11/01/1986 - "While rupture of the uterus by oxytocic agents in the second trimester has previously been documented, this case is unusual in that fetal parts were palpable through the cervical os, delaying diagnosis and definitive management. "
4.	Sepsis (Septicemia) 11/01/2005 - "Significant risk factors identified for reducing mortalities due to post abortion complications included the administration of oxytocic drugs and evacuation of the uterus whilst anaemia and sepsis apparently reduced these women's chances of survival. " 01/01/1979 - "In trapartum infections can be reduced to a minimum by keeping the membranes intact during early labour, by the aggressive use of uterine stimulants to avoid prolonged labour, by exerting extreme care to avoid sepsis during pelvic examinations and internal monitoring, and by earlier use of Caesarean section." 12/01/1986 - " Studies between 1982-85 of RU 486 alone or in combination with an oxytocic agent indicated that the effective dose varied from 400-800 mg. Serious complications were exceptional, although 1 case of septicemia occurred which was cured after treatment for retention of the products of conception. "
5.	Fetal Death 01/01/1990 - "It is concluded that 16-phenoxy-PGE2-methylsulfonylamide is an effective and safe oxytocic agent for the induction of labor in case of intrauterine fetal death with minimal effects on the coagulation system." 07/01/1978 - "This report describes a fetal death during a negative antepartum contraction stress test, without oxytocic stimulation, at 34 weeks' gestation in a woman with Class B diabetes mellitus."

Related Drugs and Biologics

1.	Oxytocin (Pitocin)
2.	Ergonovine (Ergometrine)
3.	Misoprostol (Cytotec)
4.	Dinoprostone (PGE2)
5.	Mifepristone (RU 486)
6.	carbetocin
7.	gemeprost
8.	Solutions
9.	Prostaglandins
10.	Tocolytic Agents (Tocolytics)

Related Therapies and Procedures

1.	Intramuscular Injections
2.	Aftercare (After-Treatment)
3.	Induced Labor
4.	Uterine Myomectomy
5.	Pessaries