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Oxytetracycline (Terramycin)

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A TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES rimosus and used in a wide variety of clinical conditions.

Also Known As:

Terramycin; Bisolvomycin; Geomycin; Oxyterracin; Oxyterracine; Oxytetracid; Oxytetracycline Calcium; Oxytetracycline Dihydrate; Oxytetracycline Hydrochloride; Oxytetracycline Monohydrochloride; Oxytetracycline Sulfate (2:1); Oxytetracycline, (4a beta,5 beta,5a beta,12a beta)-Isomer; Oxytetracycline, (5 beta)-Isomer; Oxytetracycline, Calcium (1:1) Salt; Oxytetracycline, Disodium Salt, Dihydrate; Oxytetracycline, Sodium Salt; Calcium, Oxytetracycline; Dihydrate, Oxytetracycline; Hydrochloride, Oxytetracycline; Sodium Salt Oxytetracycline; Hydroxytetracycline; 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-, (4S-(4alpha,4aalpha,5alpha,5aalpha,6beta,12aalpha))-

Networked: 1173 relevant articles (75 outcomes, 105 trials/studies)

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Drug Context: Research Results

Experts

1.	Booker, Calvin W: 3 articles (01/2009 - 05/2002)
2.	Jim, G Kee: 3 articles (01/2009 - 05/2002)
3.	Wildman, Brian K: 3 articles (01/2009 - 05/2002)
4.	Liu, Jia-Hong: 2 articles (07/2014 - 02/2014)
5.	Yang, Bi-E: 2 articles (07/2014 - 02/2014)
6.	Zhang, Qian-Qian: 2 articles (07/2014 - 02/2014)
7.	Jin, Ren-Cun: 2 articles (07/2014 - 02/2014)
8.	Gardner, Keri L: 2 articles (12/2012 - 04/2004)
9.	Arnoczky, Steven P: 2 articles (12/2012 - 04/2004)
10.	Lavagnino, Michael: 2 articles (12/2012 - 04/2004)

Related Diseases

1.	Infection 05/01/1986 - "Oxytetracycline given twice significantly reduced the severity of the primary infection but the secondary infection was more severe. " 05/01/1986 - "Neither compound showed prophylactic properties even though both are effective in extending the prepatent period and, in the case of oxytetracycline, reducing the severity of infection." 01/01/1986 - "Gram-negative bacteria predominate, and oxytetracycline is effective in treatment of infections induced by them. " 10/01/1983 - "Studies on the use of a long-acting oxytetracycline in turkeys: efficacy against experimental infections with Alcaligenes faecalis and Pasteurella multocida." 01/01/2007 - "Here, we report that although 24 weeks of weekly oxytetracycline treatment eliminated adult worms, cured animals remained susceptible to re-infection by natural challenge when compared with putatively immune cattle. "
2.	Anaplasmosis 09/01/1978 - "Efficacy of a new oxytetracycline formulation against clinical anaplasmosis." 01/01/1979 - "Efficacy of terramycin/LA-200 administered during the prepatent period of anaplasmosis." 01/01/1991 - "The objective of this study was to test the efficiency and acceptability of oxytetracycline hydrochloride (OTC) in anaplasmosis. " 11/15/1958 - "Laboratory studies of anaplasmosis in cattle treated with oxytetracycline." 07/01/1983 - "It was concluded that long-acting oxytetracycline can be used to eliminate the naturally acquired carrier state of anaplasmosis in cattle."
3.	Digital Dermatitis 04/01/2000 - "A field trial was conducted to compare the efficacy of the original and two modified formulations of Victory and oxytetracycline among dairy cows affected with papillomatous digital dermatitis. " 04/15/2000 - "To evaluate efficacy of topical treatment with oxytetracycline solution among dairy cows with papillomatous digital dermatitis (PDD) lesions on the interdigital cleft, heels, or dewclaw. " 04/15/2000 - "Efficacy of oxytetracycline for treatment of papillomatous digital dermatitis lesions on various anatomic locations in dairy cows." 04/01/2000 - "The 2 low efficacy of oxytetracycline was an unexpected result b and may have clinical implications associated with possible antibiotic resistance in dairy cows affected with papillomatous digital dermatitis." 03/01/1999 - "To compare efficacy of topical treatment with oxytetracycline solution or 1 of 4 nonantibiotic solutions among dairy cows with papillomatous digital dermatitis (PDD). "
4.	Fever (Fevers) 12/01/2002 - "An evaluation of the relative efficacy of a new formulation of oxytetracycline for the treatment of undifferentiated fever in feedlot calves in western Canada." 04/07/1990 - "Efficacy of long-acting oxytetracycline for the prevention of tick-borne fever in calves." 04/07/1990 - "At the end of the trial the treated group weighed on average 16 kg more than the control group, a difference which was attributed to the suppression of tick-borne fever by oxytetracycline." 09/01/1956 - "[Study on the use of terramycin in the treatment of Spanish recurrent fever]." 11/15/1996 - "To establish the maximum concentration and duration of oxytetracycline residues in milk from cows with retained fetal membranes given the antimicrobial via intrauterine infusion, and to investigate whether the number of infusions or the presence of fever (> 39.7 C) affected the duration of residues. "
5.	Body Weight (Weight, Body) 04/01/2011 - "The penetration of oxytetracycline (OTC) in plasma and nasal secretions of healthy pigs was evaluated during the first study, in response to oral dose of 20 mg of OTC per kg of body weight (bwt) per day as a 400 mg/kg feed medication (n = 5) and to intramuscular (i.m.)-administered formulations at 10 mg/kg bwt (n = 5), 20 mg/kg bwt (n = 5), 40 mg/kg bwt (n = 5). " 02/01/2011 - "The purpose of this study was to investigate the hemolymph kinetics and depuration time of oxytetracycline following intramuscular administration at doses of 2, 8 and 40 mg/kg body weight, respectively. " 12/01/1990 - "In both trials each piglet received an i/v-injection of oxytetracycline (dosage 10 mg/kg body weight) and an oral dose of oxytetracycline (40 mg/kg body weight). " 06/01/1989 - "A comparative pharmacokinetic study was conducted in rainbow trout (Salmo gairdneri) and African catfish (Clarias gariepinus) following intravenous (i.v.) and intramuscular (i.m.) administration of oxytetracycline (OTC) at a dose rate of 60 mg/kg body weight. " 04/01/2012 - "Oxytetracycline was mixed into the feed to achieve a daily dose of 82.8 mg per kg body weight at a feeding rate of 1% body weight per day. "

Related Drugs and Biologics

1.	Chlortetracycline (Aureomycin)
2.	Tetracycline (Achromycin)
3.	Doxycycline (Vibramycin)
4.	Anti-Bacterial Agents (Antibiotics)
5.	Penicillins (Penicillin)
6.	Streptomycin (Streptomycin Sulfate)
7.	Oxytetracycline (Terramycin)
8.	tilmicosin
9.	ceftiofur
10.	enrofloxacin

Related Therapies and Procedures

1.	Intramuscular Injections
2.	Injections
3.	Aftercare (After-Treatment)
4.	Oral Administration
5.	Subcutaneous Injections