Oxyphenbutazone

A non-steroidal anti-inflammatory drug. Oxyphenbutazone eyedrops have been used abroad in the management of postoperative ocular inflammation, superficial eye injuries, and episcleritis. (From AMA, Drug Evaluations Annual, 1994, p2000) It had been used by mouth in rheumatic disorders such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis but such use is no longer considered justified owing to the risk of severe hematological adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p27)

Also Known As:

Networked: 198 relevant articles (6 outcomes, 19 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Bodaghi, Bahram: 1 article (04/2011)
2.	Sharma, Om P: 1 article (04/2011)
3.	Murray, Philip I: 1 article (04/2011)
4.	Tokuda, Harukuni: 1 article (04/2010)
5.	Azuine, Magnus A: 1 article (04/2010)
6.	Shigeta, Yuuko: 1 article (04/2010)
7.	Kapadia, Govind J: 1 article (04/2010)
8.	Suzuki, Nobutaka: 1 article (04/2010)
9.	Tigka, E: 1 article (10/2005)
10.	Tesseromatis, C: 1 article (10/2005)

Related Diseases

1.	Pain (Aches) 12/01/1964 - "[CLINICAL TRIALS WITH OXYPHENBUTAZONE IN CERVICAL AND LUMBAR PAIN SYNDROMES]." 03/30/1960 - "The effect of oxyphenbutazone on pain related to vascular disease." 01/01/1978 - "The results of subjective assessments showed tha by Day 3 spontaneous pain had either completely resolved or markedly improved in all patients, and that diflunisal was significantly better than oxyphenbutazone on Days 1 and 3 in relieving pain on movement of the joint." 12/12/1983 - "Decrease in pain upon physical examination and in articular circumference was significantly greater with Bi-Profenid as compared with oxyphenbutazone. " 01/01/2004 - "The data collected in this pilot project revealed that pirfenidone was more effective (p < 0.025) than oxyphenbutazone in providing relief from arthritic pain. "
2.	Edema 04/20/1963 - "A double-blind controlled trial was carried out to test the value of oxyphenbutazone (Tandearil; Geigy Pharmaceuticals) in preventing the troublesome edema of external genitalia that may occasionally develop after bilateral inguinal herniorrhaphy. " 04/20/1963 - "Trial of oxyphenbutazone for postoperative edema after bilateral herniorrhaphy." 08/01/2003 - "In EPP-induced edema IC(50) of DMPBD and oxyphenbutazone were 21 and 136nmol per ear, respectively. " 10/01/1966 - "It appeared from the results of these observations that Oxyphenbutazone is not effective in preventing postoperative edema in such operations or in promoting more rapid resolution of postoperative edema. " 11/01/1963 - "[TANDERIL IN OTORHINOLARYNGOLOGY WITH SPECIAL REFERENCE TO THE POSTOPERATIVE EDEMA]."
3.	Wounds and Injuries (Trauma) 02/01/1971 - "[Experiences with Tanderil in winter sport injuries]." 02/01/1972 - "[Therapy and after care of superficial thrombophlebitis and of gynecological surgical wounds using Tanderil cream]." 01/01/1978 - "A double-blind randomized trial was carried out in 31 patients suffering from acute, minor ligamentous injuries to compare the efficacy of diflunisal in the relief of pain with that of oxyphenbutazone. " 05/14/1968 - "[Treatment of injuries with orally administered Varidase as compared to Chymoral and Tanderil]." 11/14/1976 - "An overall study, accompanied by some statistics, is presented of delayed bone marrow injuries caused by drugs, such as chloramphenicol, phenylbutazone, oxyphenbutazone, gold salts, sulphamides and diphenylhydantoin. "
4.	Inflammation 03/23/1963 - "The efficacy of oxyphenbutazone (OPB) in the control of postoperative inflammation was investigated, and previous findings were extended on the rate at which the inflammatory response of plasma seromucoids was significantly modified by this drug. " 01/01/1983 - "The findings show increased diffusion of oxyphenbutazone towards its site of action in inflammation." 01/01/1983 - "In synovial tissue, the oxyphenbutazone level was higher in patients with severe inflammation than in those with no or little inflammation. " 04/01/1973 - "Oxyphenbutazone in ocular inflammation." 04/01/1971 - "[The prevention of postoperative inflammation in ocular surgey by the use of Tanderil]."
5.	Erythema 07/01/1978 - "It is superior to the comparable anti-inflammatory drugs in its effect on the inflammatory erythema of the skin; in its effect on the inflammatory edema of the skin, it stands between oxyphenbutazone and indomethacin." 01/01/1982 - "In regard to the topical activity, piroxicam antagonized significantly both the croton oil edema and the UV-erythema; against the latter experiment also ketoprofen exerted intense inhibition, whilst oxyphenbutazone proved inactive. "

Related Drugs and Biologics

1.	Indomethacin (Indometacin)
2.	Diflunisal (Dolobid)
3.	Ketoprofen (Orudis)
4.	pirfenidone
5.	Oxyphenbutazone
6.	Phenylbutazone (Butazolidin)
7.	Chloramphenicol (Chloromycetin)
8.	Sodium
9.	Prednisolone (Predate)
10.	Suppositories (Vaginal Suppositories)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Compression Bandages
3.	Tooth Extraction (Tooth Extractions)
4.	Radiotherapy