Oxymorphone (Numorphan)

An opioid analgesic with actions and uses similar to those of MORPHINE, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092)

Also Known As:

Networked: 155 relevant articles (20 outcomes, 30 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Ahdieh, Harry: 13 articles (05/2010 - 06/2004)
2.	Ma, Tina: 7 articles (05/2010 - 07/2004)
3.	Gould, Errol M: 6 articles (04/2013 - 02/2009)
4.	Broz, Dita: 3 articles (12/2019 - 05/2015)
5.	Peters, Philip J: 3 articles (12/2019 - 05/2015)
6.	Weidle, Paul J: 3 articles (12/2019 - 05/2015)
7.	Dale, Ola: 3 articles (04/2012 - 02/2010)
8.	Kaasa, Stein: 3 articles (04/2012 - 02/2010)
9.	Kerwin, Rosemary: 3 articles (10/2008 - 01/2007)
10.	Rauck, Richard: 3 articles (10/2008 - 01/2007)

Related Diseases

1.	Pain (Aches) 12/01/2005 - "The mean SPID score was significantly greater in the oxymorphone IR group, showing greater pain relief, compared with the placebo group (least squares mean difference +/- standard error, 76.9+/-28.09; 95% confidence interval, 21.26-132.59; P=.007). " 02/01/2010 - "A systematic search for published studies of oral oxymorphone in the management of chronic pain was conducted. " 02/01/2010 - "A systematic review of oxymorphone in the management of chronic pain." 03/01/2021 - "Successful OR was defined as a 2-point or 30% reduction in pain score and continued use of oxymorphone at follow-up in outpatient setting, or discharge in inpatient setting. " 08/01/2014 - "Four TFS- and eight oxymorphone-treated dogs were withdrawn due to lack of pain control. "
2.	Postoperative Pain 06/01/2007 - "This study assessed the efficacy and tolerability of multiple fixed doses of oxymorphone IR in the treatment of acute postoperative pain after abdominal surgery. " 06/01/2007 - "Efficacy and tolerability of oxymorphone immediate release for acute postoperative pain after abdominal surgery: a randomized, double-blind, active- and placebo-controlled, parallel-group trial." 12/01/2005 - "Five milligrams of oxymorphone IR was well tolerated and effective at relieving mild or moderate postsurgical pain after outpatient knee surgery." 11/01/2004 - "The efficacy and safety of oral immediate-release oxymorphone for postsurgical pain." 06/01/2003 - "A single administration of LE oxymorphone hydrochloride was as effective for relief of postoperative pain in rats (P = 0.18), as were multiple (q4 h or q8 h) injections of 0.3 mg/kg of the standard pharmaceutical preparation. "
3.	Osteoarthritis 03/01/2005 - "Safety, tolerability, and effectiveness of oxymorphone extended release for moderate to severe osteoarthritis pain: a one-year study." 08/01/2010 - "This post hoc analysis of oxymorphone ER consumption in osteoarthritis pain vs pain report showed that most dose changes occurred during an initial "titration period" as defined. " 09/01/2005 - "To compare oxymorphone extended release (ER) and placebo on indices of pain, function, and safety in patients with chronic osteoarthritis (OA) pain. " 01/01/2003 - "Late in 2002, the Oxymorphone formulation successfully completed a phase III clinical trial in patients with osteoarthritis pain. " 04/01/2013 - "A secondary analysis was performed using data from a prospective, multicenter, double-blind placebo-controlled, and active-controlled parallel group dose-ranging study comparing the efficacy of oxymorphone extended release (ER) 20 mg (ER20, N=121); oxymorphone ER 40 mg (ER40, N=121); oxycodone controlled release 20 mg (Oxy20, N=125); and placebo (N=124) in a sample of patients with osteoarthritis. "
4.	Low Back Pain (Lumbago) 01/01/2005 - "Efficacy and safety of oxymorphone extended release in chronic low back pain: results of a randomized, double-blind, placebo- and active-controlled phase III study." 08/01/2010 - "Factors affecting acceptability of titrated oxymorphone extended release in chronic low back pain - an individual patient analysis." 02/01/2009 - "In patients aged > or =18 years with chronic low back pain, the dose of oxymorphone ER was titrated to a stable, tolerable, effective dose. " 02/01/2009 - "The results indicate that oxymorphone ER has different effects on different pain qualities of low back pain. " 02/01/2009 - "The pain quality response profile of oxymorphone extended release in the treatment of low back pain."
5.	Chronic Pain 07/01/2007 - "Oral extended-release oxymorphone: a new choice for chronic pain relief." 12/01/2017 - "Oxymorphone Hydrochloride Extended-Release (OPANA®) Associated With Acute Kidney Injury in a Chronic Pain Patient: A Case Report." 01/01/2018 - "We strongly urge physicians to avoid prescribing opiates for chronic pain, especially Opana ER, which if injected intravenously for recreational purposes can lead to serious side effects like TMA. " 01/01/2018 - "Oxymorphone is a semisynthetic extended release opiate used to treat moderate to severe chronic pain. " 12/01/2017 - "Oxymorphone hydrochloride extended-release (OPANA®) is an opioid prescribed for the treatment of moderate-to-severe chronic pain. "

Related Drugs and Biologics

1.	Opioid Analgesics (Opioids)
2.	Oxymorphone (Numorphan)
3.	Oxycodone (Oxycontin)
4.	Morphine (MS Contin)
5.	Analgesics (Analgesic Drugs)
6.	Tablets
7.	Dextropropoxyphene (Darvon)
8.	Ketoprofen (Orudis)
9.	Narcotics (Narcotic Analgesics)
10.	Acetaminophen (Paracetamol)

Related Therapies and Procedures

1.	Analgesia
2.	Injections
3.	Subcutaneous Injections
4.	Knee Replacement Arthroplasty (Total Knee Replacement)
5.	Thoracotomy