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Oxamniquine

An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martindale, The Extra Pharmacopoeia, 31st ed, p121)
Also Known As:
Oxaminiquine; UK-4271; UK 4271; UK4271; 6-Quinolinemethanol, 1,2,3,4-tetrahydro-2-(((1-methylethyl)amino)methyl)-7-nitro-
Networked: 195 relevant articles (22 outcomes, 24 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Cao, Xiaohang: 3 articles (10/2018 - 01/2016)
2. Hart, P John: 3 articles (10/2018 - 01/2016)
3. LoVerde, Philip T: 3 articles (10/2018 - 01/2016)
4. Coelho, Paulo Marcos Zech: 3 articles (11/2013 - 08/2008)
5. Katz, Naftale: 3 articles (11/2013 - 08/2008)
6. Anderson, Timothy J C: 2 articles (10/2018 - 01/2016)
7. Chevalier, Frédéric D: 2 articles (10/2018 - 01/2016)
8. McHardy, Stanton F: 2 articles (10/2018 - 01/2017)
9. Tarpley, Reid S: 2 articles (10/2018 - 01/2017)
10. Taylor, Alexander B: 2 articles (10/2018 - 01/2017)

Related Diseases

1. Schistosomiasis mansoni
2. Schistosomiasis (Bilharziasis)
3. Infections
4. Body Weight (Weight, Body)
5. Reinfection
06/01/1988 - "It is concluded that oxamniquine need not be given in the previously recommended 60 mg/kg body wt. A choice between 40 and 20 mg/kg body wt is suggested with the 40 mg/kg body wt to be reserved for individuals leaving the endemic area, and the 20 mg/kg body wt for those continuing to stay there with substantial exposure for reinfection. "
01/01/1987 - "Neither resistance to the drug (oxamniquine) nor its deterioration could be held responsible, since a short-term follow-up of a group of children personally treated by the authors showed rapid reinfection, after an excellent initial response. "
01/01/1987 - "Group mean Schistosoma mansoni reinfection patterns are presented for 2 years after treatment with oxamniquine in 1981 of over 100 9- to 16-year-old Kenyan schoolchildren, and for one year after retreatment in 1983 with either oxamniquine or praziquantel when most (nearly 700) infected people in the whole community were treated. "
10/01/2015 - "While chemotherepeutic drugs, such as praziquantel, oxamniquine and metrifonate, are currently considered safe and effective drugs for schistosomiasis treatment, reinfection occurs frequently after drug treatment. "
03/01/1980 - "mansoni infections with any one of five schistosomicidal agents (Oxamniquine, Praziquantel, potassium antimony tartrate, Niridazole and Hycanthone) resulted in a reduction in the degree of resistance to homologous challenge in the treated animals when compared with the level of resistance to reinfection observed in untreated mice with intact primary infections. "

Related Drugs and Biologics

1. Praziquantel (Biltricide)
2. Oxamniquine
3. Trichlorfon (Metrifonate)
4. Hycanthone
5. Schistosomicides
6. Antimony
7. meclonazepam
8. Immunoglobulin E (IgE)
9. Sugars
10. Ro 15-5458

Related Therapies and Procedures

1. Aftercare (After-Treatment)
2. Therapeutics
3. Drug Therapy (Chemotherapy)
4. Retreatment
5. Splenectomy