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Ovariectomy (Oophorectomy)

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The surgical removal of one or both ovaries.

Also Known As:

Oophorectomy; Bilateral Ovariectomy; Bilateral Ovariectomies; Castrations, Female; Female Castration; Female Castrations; Oophorectomies; Ovariectomies; Ovariectomies, Bilateral; Ovariectomy, Bilateral; Castration, Female

Networked: 5167 relevant articles (193 outcomes, 517 trials/studies)

Relationship Network

Therapy Context: Research Results

Operative Surgical Procedures: 8
- Endocrine Surgical Procedures: 1
  - Castration: 5290
    - Ovariectomy: 5167
- Urogenital Surgical Procedures
  - Castration: 5290
    - Ovariectomy: 5167
  - Gynecologic Surgical Procedures: 951
    - Ovariectomy: 5167

Experts

1.	Narod, Steven A: 35 articles (11/2015 - 02/2002)
2.	Lynch, Henry T: 29 articles (09/2015 - 05/2002)
3.	Isaacs, Claudine: 20 articles (11/2014 - 05/2002)
4.	Sun, Ping: 19 articles (07/2015 - 06/2004)
5.	Tung, Nadine: 19 articles (06/2015 - 06/2004)
6.	Daly, Mary B: 18 articles (05/2015 - 05/2002)
7.	Rosen, Barry: 17 articles (11/2015 - 06/2002)
8.	Ghadirian, Parviz: 17 articles (09/2015 - 06/2004)
9.	Foulkes, William D: 17 articles (07/2015 - 06/2004)
10.	Kim-Sing, Charmaine: 16 articles (09/2015 - 06/2005)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2012 - "Risk-reducing salpingo-oophorectomy is highly effective in preventing ovarian, fallopian tube, and breast cancers in a high-risk French Canadian population; and the surgical morbidity is low." 01/01/1994 - "The remission rates of tumors found after treatment with ICI, ON, the combination and ovariectomy (complete and partial remission) were 15%, 46%, 71% and 100% respectively. " 07/01/2004 - "Radical interventions, such as extensive tumor debulking and oophorectomy for hormonal control, although effective in many cases, are not always possible or desirable and carry significant morbidity. " 10/01/2003 - "We report 2 patients with metastatic ovarian tumors of gastric origin who underwent oophorectomy with paraaortic and intrapelvic lymph node dissection, and showed a relatively good outcome. " 05/15/1997 - "On the basis of a range of estimates of the incidence of cancer, prognosis, and efficacy of prophylactic surgery, our model suggests that prophylactic mastectomy provides substantial gains in life expectancy and prophylactic oophorectomy more limited gains for young women with BRCA1 or BRCA2 mutations."
2.	Breast Neoplasms (Breast Cancer) 07/01/2012 - "There was a highly significant reduction in breast cancer risk among women who had an oophorectomy after natural menopause (OR, 0.13; 95% CI, 0.02-0.54; P = 0.006). " 05/01/2011 - "Oophorectomy was associated with a significant reduction in the risk of ipsilateral breast cancer (RR 0.33; 95% CI; 0.13-0.81; P = 0.02). " 10/20/2005 - "A previous history of oophorectomy was associated with a significant reduction in breast cancer risk of 56% for BRCA1 carriers (OR = 0.44; 95% CI, 0.29 to 0.66) and of 46% for BRCA2 carriers (OR = 0.57; 95% CI, 0.28 to 1.15). " 10/01/2003 - "Because of the uncertain efficacy of breast cancer screening in women at increased risk of developing breast cancer, bilateral prophylactic oophorectomy and mastectomy are considered management options for high-risk women. " 09/01/1999 - "We found a statistically significant reduction in breast cancer risk after bilateral prophylactic oophorectomy, with an adjusted hazard ratio (HR) of 0.53 (95% confidence interval [CI] = 0.33-0.84). "
3.	Osteoporosis 12/23/2014 - "Furthermore, the in vivo results of an ovariectomy (OVX)-induced osteoporosis model showed that CUR-CGNPs significantly improved bone density and prevented bone loss. " 01/01/2013 - "Combined ovariectomy and deficient diet in rats caused significant reduction of BMD, BMC, and bone area, with nearly 40% bone loss after 14 months, indicating the development of severe osteoporosis. " 07/01/2009 - "The results indicate that the injected Mg/Zn/F-CaP compounds were effective in preventing bone loss induced by ovariectomy in rats and suggest that these compounds have potential use for treating osteoporosis." 01/01/2007 - "We investigated whether treatments with beta-blockers or other administrations that have similar actions to beta-blockers, such as Chinese herbs or needling, were effective in treating osteoporosis induced by ovariectomy (OVX). " 01/01/2004 - "The flavonoid extract from Epimedium sagittatum (FES) has been found by us to be effective in preventing osteoporosis induced by ovariectomy in rats. "
4.	Ovarian Neoplasms (Ovarian Cancer) 11/01/2000 - "Because most options for ovarian cancer prevention are not highly efficacious, many high-risk women consider the option of bilateral prophylactic oophorectomy (BPO), in the hope that removal of healthy ovarian tissue will reduce their risk of developing invasive malignancy. " 11/01/1991 - "This article presents the background, rationale, and structure of the Yale Early Detection Program for ovarian cancer, whose goals are to identify the best techniques for diagnosing ovarian cancer in an early stage, to determine the frequency with which such tests should be employed, to assess false-positive results, and to identify women who might benefit from prophylactic oophorectomies." 09/01/2010 - "If proven effective, this technique can be useful in screening women at high risk of developing ovarian cancer to determine whether oophorectomy is necessary." 07/10/2007 - "Because of limitations in the efficacy of available screening and chemopreventive approaches for women with a mutation in one of these genes, surgical risk reduction, particularly risk-reducing salpingo-oophorectomy (RRSO), has become an important component of the management options in hereditary breast-ovarian cancer syndrome. " 04/01/2009 - "Risk-reducing salpingo-oophorectomy (RRSO) provides effective protection against ovarian cancer in BRCA mutation carriers and in women at risk for hereditary breast ovarian cancer, but little is known about non-oncologic morbidity after the procedure. "
5.	Endometriosis (Adenomyosis) 02/01/2010 - "Induction of a local pseudo-pregnancy could achieve therapeutic efficacy comparable to that of ovariectomy without provoking any marked side effects in a rabbit endometriosis model. " 10/01/2013 - "Total abdominal hysterectomy and bilateral salpingo-oophorectomy for endometriosis results in a significant improvement in HRQoL. " 11/01/1992 - "Although there are a variety of treatment options, the only cure for endometriosis is total abdominal hysterectomy with bilateral oophorectomy. " 06/01/2008 - "One hundred twenty patients who underwent hysterectomy with or without oophorectomy for endometriosis and 120 patients who had laparoscopic excision of their endometriotic lesions only (local excision group) formed the study population. " 07/01/2005 - "This was a descriptive study that comprised 38 patients who underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy between 1989 and 2002 for symptomatic recurrences of deep endometriosis, after>or=1 previous surgical procedures and ovarian suppressive medical treatments. "

Related Drugs and Biologics

1.	Estrogens (Estrogen)
2.	Hormones
3.	Tamoxifen
4.	Gonadotropin-Releasing Hormone (GnRH)
5.	Estradiol (Estrace)
6.	Testosterone (Sustanon)
7.	Goserelin (Zoladex)
8.	Progesterone
9.	9,10-Dimethyl-1,2-benzanthracene (DMBA)
10.	Estrogen Receptor Modulators (Antiestrogen)

Related Therapies and Procedures

1.	Hysterectomy
2.	Mastectomy (Mammectomy)
3.	Drug Therapy (Chemotherapy)
4.	Lymph Node Excision (Lymph Node Dissection)
5.	Hypophysectomy