Otosclerosis

Formation of spongy bone in the labyrinth capsule which can progress toward the STAPES (stapedial fixation) or anteriorly toward the COCHLEA leading to conductive, sensorineural, or mixed HEARING LOSS. Several genes are associated with familial otosclerosis with varied clinical signs.

Also Known As:

Networked: 930 relevant articles (34 outcomes, 121 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hearing Loss (Hearing Impairment)
2.	Tinnitus
3.	Meniere Disease (Menieres Disease)
4.	Meningitis
5.	Conductive Hearing Loss

Experts

1.	Karosi, Tamás: 18 articles (08/2014 - 07/2005)
2.	Sziklai, István: 16 articles (08/2014 - 07/2005)
3.	Grolman, Wilko: 15 articles (12/2014 - 01/2002)
4.	Vincent, Robert: 12 articles (12/2014 - 12/2006)
5.	Tange, Rinze A: 9 articles (09/2014 - 01/2002)
6.	Csomor, Péter: 9 articles (08/2014 - 12/2009)
7.	McKenna, Michael J: 8 articles (07/2015 - 02/2002)
8.	Kónya, József: 8 articles (03/2011 - 07/2005)
9.	Wegner, Inge: 7 articles (12/2014 - 09/2013)
10.	Bittermann, Arnold J N: 7 articles (12/2014 - 08/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Otosclerosis:

1.	Polytetrafluoroethylene (Teflon)FDA Link 01/01/1997 - "This study reports the evaluation of hearing results after implantation of a Teflon piston of a different diameter in cases of otosclerosis requiring stapedotomy. " 08/01/2006 - "It is suggested that small fenestra stapedotomy with Teflon piston artificial stapes is an ideal surgical treatment for otosclerosis." 12/01/1991 - "Three groups of patients were matched for age, sex, clinical type of otosclerosis, and type of 0.6-mm all-Teflon piston. " 10/01/1967 - "[Presentation of a film: "Teflon interposition in the surgery of otospongiosis"]." 05/01/1967 - "[Teflon interposition in the surgery of otospongiosis]."
2.	Sodium Fluoride (Ossin)FDA Link 06/01/2010 - "There has been only one double-blind, placebo-controlled trial of the use of sodium fluoride in otosclerosis patients, and this found a reduced incidence of deterioration in hearing after two years in the treatment group. " 01/01/1989 - "The effect of sodium fluoride treatment in patients with otospongiosis has been evaluated in a prospective clinical double-blind, placebo-controlled study of 95 patients. " 01/01/1989 - "A clinical double-blind, placebo-controlled study on sodium fluoride treatment in otospongiosis." 03/01/1985 - "The effect of sodium fluoride treatment in patients with otospongiosis has been evaluated blindly in a morphological and microchemical element analysis of otospongiotic specimens together with a prospective clinical double-blind, placebo-controlled study. " 06/01/2010 - "There is low quality evidence suggesting that sodium fluoride may be of benefit to preserve hearing and reduce vestibular symptoms in patients with otosclerosis."
3.	TitaniumIBA 07/01/2013 - "The use of the titanium soft clip stapes piston gives good results in cases of stapedotomy for otosclerosis. " 07/01/2013 - "Case records of 20 patients of otosclerosis who had undergone stapedotomy using titanium soft clip stapes piston (Kurz, Germany) were retrospectively analysed. " 06/01/2008 - "An analysis of the air-bone gap closure obtained by a crimping and a non-crimping titanium stapes prosthesis in otosclerosis." 11/01/2003 - "The new low-weight, full-titanium stapes prosthesis with its slight rough surface and its good mechanical stability and biocompatibility can safely and successfully restore the function of the middle ear when implanted in patients with otosclerosis." 11/01/2003 - "To evaluate the early postoperative hearing results of a new titanium stapes prosthesis (K-Piston) implanted in patients with otosclerosis. "
4.	DiphosphonatesIBA 06/01/1997 - "Prospective blinded efficacy studies of the bisphosphonates in the treatment of otosclerosis should be undertaken." 07/01/2015 - "Local delivery of bisphosphonates results in superior localization of these compounds for the treatment of cochlear otosclerosis, without ototoxicity. " 01/01/2008 - "Applying the understanding of osteoclastogenesis to the treatment of otosclerosis has led to the clinical use of the class of drugs called bisphosphonates. " 01/01/2008 - "Medical treatment of otosclerosis: rationale for use of bisphosphonates." 01/01/1985 - "Diphosphonates for otospongiosis."
5.	zoledronic acid (zoledronate)FDA Link 10/01/2012 - "Treatment with zoledronate or risedronate stabilized progressive SNHL related to otosclerosis in this small group of patients. " 10/01/2012 - "We hypothesized that newer generation bisphosphonates, such as risedronate and zoledronate, would be effective in slowing the progression of SNHL in patients with otosclerosis. " 07/01/2015 - "Nitrogen-containing bisphosphonates (e.g., zoledronate) are potent inhibitors of bone remodeling with proven efficacy in the treatment of metabolic bone diseases, including otosclerosis. "
6.	PlatinumIBA 01/01/2003 - "Evaluation of hearing results after implantation of a fluoroplastic-platinum piston (FP) and of a titanium piston (T) with a shaft diameter of respectively 0.6 mm and 0.4 mm, in cases of otosclerosis requiring stapedotomy. " 04/01/1999 - "Two hundred ears with otosclerosis have been operated upon using a 0.4-mm diameter Teflon platinum piston in 100 ears and a 0.6-mm diameter Teflon piston in the other 100 ears. " 09/01/1993 - "Otosclerosis is treated by a 'small-fenestra' stapedotomy with insertion of a teflon-platinum wire piston. " 02/01/1999 - "For many years good results in otosclerosis surgery have been achieved with a prosthesis made of platinum-wire and Teflon. " 08/01/2007 - "These data show that the nitinol prosthesis is equivalent to the platinum wire prosthesis in closing the ABG in patients with otosclerosis. "
7.	Transforming Growth Factor beta1 (TGF beta 1)IBA 09/01/2007 - "On the basis of very low P-values, replication in an independent population and a functional effect of the protective variant, we conclude that TGF-beta1 influences the susceptibility for otosclerosis, and that the I263 variant is protective against the disease." 12/01/2009 - "Data from both genetic association studies and gene expression analysis of otosclerotic bone showed that the TGF-beta1 pathway is most likely an important factor in the pathogenesis of otosclerosis." 03/01/2009 - "Taking into account that most rare missense alleles are thought to have a biological effect, the data suggest that multiple rare amino acid changing variants in TGF-beta1 may contribute to susceptibility to otosclerosis." 09/01/2008 - "Otosclerosis and TGF-beta 1 gene in black South Africans." 09/01/2007 - "The coding polymorphism T263I in TGF-beta1 is associated with otosclerosis in two independent populations."
8.	GoldIBA 09/01/1998 - "This study shows that the use of a pure gold piston ((K-piston) with a diameter of 0.4 mm gives good results in cases of stapedotomy for otosclerosis. " 09/01/1998 - "This study reports the evaluation of the hearing results after 62 implantations of a pure gold (99.9%) piston in cases of otosclerosis. " 09/01/1998 - "Experience with a new pure gold piston in stapedotomy for cases of otosclerosis." 01/01/2002 - "four hundred and seventy five patients (328 women, 147 men, average age: 45.2 years), who clinically and per-operatively had otosclerosis, underwent a stapedotomy using a pure gold piston prosthesis. " 01/01/2002 - "to determine the occurrence of the unusual side effect of a reparative granuloma after the implantation of a pure gold piston in cases of otosclerosis. "
9.	Etidronic Acid (HEDP)FDA LinkGeneric 06/01/1997 - "In this preliminary study etidronate appeared to be an effective treatment for the neurotologic symptoms of otosclerosis. " 06/01/1997 - "Etidronate for the the neurotologic symptoms of otosclerosis: preliminary study." 09/01/1993 - "A 2-year prospective double-blind study was performed to evaluate the role of etidronate disodium for the treatment of progressive hearing loss in patients with otosclerosis. " 09/01/1993 - "The effects of etidronate disodium on progressive hearing loss from otosclerosis." 06/01/1997 - "The efficacy of etidronate, a bisphosphonate, was assessed as a treatment for the inner ear symptoms of otosclerosis in a retrospective case review of 896 patients diagnosed with otosclerosis, with primary complaints of dizziness, hearing loss, tinnitus or Meniere's syndrome. "
10.	ArgonIBA 12/01/1990 - "Argon-laser stapedotomy using a hand-held fiberoptic system is a safe and effective alternative to drill-out stapedotomy in cases of obliterative otosclerosis." 03/01/2005 - "To report and analyse our results and complications of argon laser assisted stapedotomy for primary otosclerosis. " 03/01/2005 - "Argon laser assisted small fenestra stapedotomy for otosclerosis." 10/02/2000 - "Argon laser stapedotomy is a new modality for the treatment of otosclerosis. " 10/02/2000 - "[Surgical treatment of otosclerosis with argon laser]."

Therapies and Procedures

1.	Stapes Surgery (Stapedectomy) 03/01/2007 - "Stapedectomy is currently the treatment with which the best results are obtained among patients with otosclerosis, which is why it is the treatment of choice. " 02/01/1994 - "Stapedectomy is known to give good results for otosclerosis. " 09/01/2005 - "Stapes surgery is effective operation to cured otosclerosis, advanced otosclerosis or far-advanced otosclerosis had greater help to improved hearing." 11/01/1996 - "Stapedectomy is a safe and effective treatment for otosclerosis and tympanosclerosis in pediatric patients." 02/01/2013 - "To study objective or subjective preoperative factors predicting improvement in listening capabilities and patient satisfaction after stapes surgery in otosclerosis. "
2.	Prostheses and Implants (Prosthesis) 01/01/2012 - "Developments in surgical technique and, more importantly, the use of increasingly sophisticated biocompatible prostheses have meant that good results can be achieved for otosclerosis sufferers in terms of restored hearing and very little postsurgical discomfort. " 01/01/2015 - "To identify whether measurement of the prosthesis length is mandatory in patients requiring otosclerosis surgeries and to assess their postoperative audiometric outcomes. " 12/01/2014 - "Thus, we have shown that attachment of the prosthesis to the PSA does not necessarily disturb improvement of hearing level after malleus-stapedotomy for otosclerosis with PSA. " 08/01/2014 - "The prosthesis length in malleostapedotomy for otosclerosis revision surgery can be calculated if the prosthesis length of previous conventional incus stapedotomy is known. " 08/01/2014 - "Is the prosthesis length in malleostapedotomy for otosclerosis revision surgery predictable?"
3.	Cochlear Implantation 09/01/2004 - "The objective of this study was to discuss cochlear implantation in the setting of severe cochlear otosclerosis and review programming challenges in a patient whose performance is deteriorating as a result of advancing disease. " 06/01/2004 - "Even if the number of patients reported in this study is too small to provide definitive results, and despite the reportedly better results afforded by cochlear implantation, in our opinion, correction of far advanced otosclerosis should first be attempted via stapedotomy, and cochlear implantation should instead be reserved for cases in which stapedotomy is unsuccessful or for which imaging techniques unequivocally reveal a fenestral or cochlear obstruction." 03/01/2015 - "Decisive criteria between stapedotomy and cochlear implantation in patients with far advanced otosclerosis." 09/01/2014 - "Cochlear implantation outcomes in advanced otosclerosis." 12/01/2013 - "A complication of cochlear implantation is facial nerve stimulation (FNS) known to be more common in otosclerosis. "
4.	Gas Lasers 12/01/2010 - "Our data, supported by the literature, suggest that 1-shot CO2 laser stapedotomy is an effective and safe procedure for the treatment of otosclerosis." 08/01/2007 - "Any patients who underwent CO2 laser stapedotomy for diseases other than otosclerosis and those who had revision surgery were excluded from the present study. " 12/01/2013 - "To compare bone conduction after fiber-enabled CO2 laser perforation of the stapes footplate with conduction after the "one-shot" technique during stapedotomy in patients with otosclerosis. " 08/01/2012 - "KTP versus CO2 laser fiber stapedotomy for primary otosclerosis: results of a new comparative series with the otology-neurotology database." 12/01/2010 - "From January to December 2008, 58 subjects underwent "1-shot" CO2 laser stapedotomies for otosclerosis. "
5.	Lasers (Laser) 04/01/2002 - "The high success rate and low incidence of serious complications support stapedotomy, without a laser but with resident involvement, as a highly effective treatment for otosclerosis." 01/01/2013 - "The objective of the present study was to compare the immediate result of laser-assisted piston stapedoplasty with the use of prosthetic stapes of different diameter in the patients with otosclerosis. " 03/01/2010 - "Patients who have been diagnosed otosclerosis and those who were not willing for surgery with laser, but gave consent for manual stapedotomy were included for the study. " 12/01/2009 - "The objective of this study was to describe the pattern of bone-conduction threshold responses preoperatively in patients with otosclerosis and to assess overclosure after laser-assisted stapedotomy. " 01/01/1971 - "[Otosclerosis, laser microprobe studies of altered stapes mineralization]."