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Otitis Media with Effusion

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Inflammation of the middle ear with a clear pale yellow-colored transudate.

Also Known As:

Ear Effusion, Middle; Ear Effusions, Middle; Effusion, Middle Ear; Effusions, Middle Ear; Middle Ear Effusions; Secretory Otitis Media; Serous Otitis Media; Middle Ear Effusion; Otitis Media, Secretory; Otitis Media, Serous

Networked: 1523 relevant articles (123 outcomes, 276 trials/studies)

Relationship Network

Disease Context: Research Results

Otorhinolaryngologic Diseases: 130
- Ear Diseases: 150
  - Otitis: 679
    - Otitis Media: 3849
      - Otitis Media with Effusion: 1523

Related Diseases

1.	Otitis Media with Effusion
2.	Otitis Media
3.	Body Weight (Weight, Body)
4.	Hypersensitivity (Allergy)
5.	Infection

Experts

1.	Yeo, Seung Geun: 15 articles (02/2015 - 04/2007)
2.	Iino, Yukiko: 11 articles (12/2015 - 10/2003)
3.	Skotnicka, Bozena: 9 articles (01/2012 - 01/2002)
4.	Wysocka, Jolanta: 9 articles (01/2012 - 01/2002)
5.	Kim, Young Il: 8 articles (02/2015 - 12/2008)
6.	Park, Dong Choon: 7 articles (11/2013 - 04/2007)
7.	Zelazowska-Rutkowska, Beata: 7 articles (01/2012 - 01/2006)
8.	Hassmann-Poznańska, Elzbieta: 7 articles (07/2010 - 01/2002)
9.	Kanazawa, Hiromi: 6 articles (12/2015 - 01/2010)
10.	Yoshida, Naohiro: 6 articles (12/2015 - 09/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Otitis Media with Effusion:

1.	Amoxicillin (Wymox)FDA LinkGeneric 12/01/1996 - "This trial compared the efficacy of amoxicillin prophylaxis with that of placebo for the management of recurrent middle ear effusion (MEE) in children. " 12/18/1991 - "We report the reexamination of a previously published study by Mandel et al that evaluated the efficacy of a 2-week course of antimicrobials (amoxicillin trihydrate) with and without a 4-week course of an oral decongestant-antihistamine combination in a double-blind, placebo-controlled, randomized trial involving 518 infants and children with otitis media with effusion. " 02/19/1987 - "Efficacy of amoxicillin with and without decongestant-antihistamine for otitis media with effusion in children. " 12/01/2002 - "Therefore, we conclude that treatment with the dose and type of steroid used in this study should not be universally recommended for treatment of chronic otitis media with effusion, and treatment with amoxicillin, if used, should not continue beyond 14 days." 12/18/1991 - "Amoxicillin with and without decongestant-antihistamine combination is not effective for the treatment of persistent asymptomatic middle-ear effusions in infants and children."
2.	Anti-Bacterial Agents (Antibiotics)IBA 04/01/2003 - "Are antibiotics effective for otitis media with effusion?" 06/01/1990 - "This study is designed to demonstrate the efficacy of antibiotics administered in a single daily dose in the management of persistent otitis media with effusion (POME). " 01/01/2012 - " were unable to find evidence of a substantial improvement in hearing as a result of the use of antibiotics for otitis media with effusion; nor did we find an effect on the rate of ventilation tube insertion. " 09/01/1998 - "In light of the fact that secretory otitis media is a benign and transient condition, that treatment with antibiotics or insertion of ventilation tubes is not without problems, and that the chance of improving the condition by autoinflation is approximately 50%, it is concluded that autoinflation should be considered first-line treatment, before antibiotic or surgical treatment is planned." 04/01/1986 - "Efficacy of oral antibiotics for the treatment of persistent otitis media with effusion."
3.	SteroidsIBA 01/01/2009 - "Topical steroids are unlikely to be an effective treatment for otitis media with effusion in general practice. " 10/01/2015 - "The Efficacy of Nasal Steroids in Treatment of Otitis Media with Effusion: A Comparative Study." 07/01/2014 - "Based on a single RCT, nasal steroids showed no improvement in symptoms or middle ear function for patients with otitis media with effusion and/or negative middle ear pressure. " 12/01/1990 - "One hundred thirty-six children with otitis media with effusion of at least 2 months' duration were investigated in a strict, double-blind, randomized prospective study to evaluate the efficacy of oral steroids in the treatment of this disease. " 12/01/1990 - "The efficacy of oral steroids in the treatment of persistent otitis media with effusion."
4.	Erythromycin (Erycette)FDA LinkGeneric 06/01/1993 - "Sixteen patients with both sinobronchial syndrome and otitis media with effusion were given low-dose and long-term erythromycin therapy (erythromycin base, 600 mg/d for more than 4 months); of these, 13 became effusion-free and most subjects showed improvement in the symptoms of sinobronchial syndrome. " 06/01/1993 - "The erythromycin therapy thus seems to be exceedingly effective for the treatment of sinobronchial syndrome and associated otitis media with effusion." 06/01/1993 - "This study was carried out to determine the incidence of otitis media with effusion in the patients with sinobronchial syndrome and to investigate the efficacy of low-dose and long-term erythromycin therapy for otitis media with effusion associated with sinobronchial syndrome. " 08/01/1996 - "The clinical efficacy of erythromycin (EM) therapy has been demonstrated in otitis media with effusion (OME). " 01/01/1998 - "Effect of erythromycin on otitis media with effusion in experimental rat model."
5.	Cefaclor (Ceclor)FDA LinkGeneric 10/01/2002 - "To study the influence of Cefaclor and Prednisonum to the expression of cell adhesion molecule in experimental otitis media with effusion (OME). " 01/01/1985 - "Penetration of cefaclor to adenoid tissue and middle ear effusion in chronic OME." 01/01/1985 - "Cefaclor in the treatment of otitis media with effusion." 01/01/1985 - "The results are put in relation to the penetration of cefaclor to adenoid tissue and middle ear effusion in chronic OME." 01/01/1983 - "Penetration of cefaclor to adenoid tissue and middle ear fluid in secretory otitis media."
6.	Dexamethasone (Maxidex)FDA LinkGeneric 02/01/1985 - "Four weeks after completing treatment, 1/26 (4%) patients receiving dexamethasone and 2/23 (9%) patients receiving placebo had completely cleared their middle ear effusion (95% confidence interval -0.05 +/- 0.14). " 02/01/1985 - "Oral dexamethasone as used in this study was not effective in treating persistent middle ear effusion in children." 02/01/1985 - "A double-blind controlled study of oral dexamethasone (in a 2-week tapering dose from .15 mg/kg/d) v placebo in 49 pediatric patients (mean age 3.7 years) with persistent asymptomatic middle ear effusion of three or more weeks duration was conducted. " 12/01/2013 - "Effectiveness of intratympanic dexamethasone in otitis media with effusion resistant to conventional therapy." 01/01/1997 - "Dexamethasone inhibits the development of endotoxin-induced otitis media with effusion."
7.	Cefixime (Suprax)FDA Link 10/01/1987 - "Cefixime, a new third generation cephalosporin antibiotic for oral use, was evaluated for safety and efficacy in the treatment of children with acute otitis media with effusion. " 08/01/1997 - "Middle ear effusion concentrations of cefixime during acute otitis media with effusion and otitis media with effusion." 10/01/1987 - "Results of this study demonstrate that cefixime given once daily is as safe and effective as amoxicillin in the treatment of acute otitis media with effusion in children and has the possible advantage of less frequent dosing." 05/01/1997 - "With the objective of evaluating the efficacy of cefixime and the combination of cefixime and betamethasone in the treatment of secretory otitis media (SOM), we enrolled 142 children 2 to 12 years old in a randomized, double-blind, placebo-controlled study. " 10/01/1987 - "Randomized, open label, multicenter trial of cefixime compared with amoxicillin for treatment of acute otitis media with effusion."
8.	Carbocysteine (S-Carboxymethylcysteine)IBA 05/01/2006 - "Efficacy of S-carboxymethyl-L-cysteine for otitis media with effusion." 07/01/1994 - "Effect of S-carboxymethylcysteine on the clearance of middle ear effusion. " 01/01/2001 - "Studies were randomised, double-blind comparisons of S-carboxymethylcysteine (any dose and duration) with placebo in otitis media with effusion. " 08/01/2000 - "A recent meta-analysis suggested a possible beneficial effect of carboxymethylcysteine (Mucodyne) in resolving otitis media with effusion (OME), but the methodology in several of the included trials was flawed. " 01/01/1988 - "We carried out a double blind comparative trial with placebo serving as control using 250 cases of infant otitis media with effusion (OME) in order to objectively evaluate the clinical usefulness of S-carboxymethylcysteine (S-CMC), an oral mucolytic agent, against OME. "
9.	Amoxicillin-Potassium Clavulanate Combination (Co-amoxiclav)FDA Link 09/14/1996 - "Double-blind randomised trial of co-amoxiclav versus placebo for persistent otitis media with effusion in general practice." 02/01/1994 - "The presence of otitis media with effusion (OME) and high negative pressure (-200 to -400 mm H2O), were investigated in the follow-up of a randomized double-blind placebo-controlled trial on the efficacy of amoxicillin/clavulanic acid in the treatment of acute otitis media. " 07/15/1989 - "The addition of myringotomy to augmentin did not seem to affect either the persistence of the infection after treatment or the residual middle ear effusion." 09/15/1998 - "A total of 386 children, aged 1-10, with secretory otitis media for at least 3 months were randomly allocated to 2 or 4 weeks' treatment with penicillin-V (Primcillin) or amoxicillin + clavulanic acid (Spektramox). " 02/01/1988 - "A double-blind randomized clinical trial was conducted at two sites comparing amoxicillin-clavulanate potassium (Augmentin) and amoxicillin trihydrate for the treatment of otitis media with effusion ("secretory otitis media"). "
10.	mometasone furoate (mometasone)FDA LinkGeneric 10/01/2015 - "There was improvement in otitis media with effusion, 40% versus 72%, pure tone audiometry 5.2±11 versus 11.6±11dB, WMD -6.40dB [-12.65, -0.15], and quality of life with mometasone. " 08/01/2009 - "To determine the clinical effectiveness and cost-effectiveness of topical mometasone in children with bilateral otitis media with effusion (OME). " 11/01/2014 - "Mometasone nasal spray appears to be effective for the treatment of otitis media with effusion in patients of adenoidal hypertrophy." 11/01/2014 - "To study the effects of topical intranasal mometasone furoate nasal spray for management of otitis media with effusion in children aged 2-12 years with adenoidal hypertrophy and its impact on change in quality of life. " 11/01/2014 - "A double-blind randomized placebo-controlled trial of topical intranasal mometasone furoate nasal spray in children of adenoidal hypertrophy with otitis media with effusion."

Therapies and Procedures

1.	Middle Ear Ventilation (Tympanostomy) 12/08/2000 - "Tympanostomy tubes are beneficial in chronic otitis media with effusion (OME), but of less value in recurrent AOM absent chronic OME. " 04/01/1999 - "Patients with thick middle ear effusions and age younger than 3 years have a significantly greater incidence of early otorrhea after tympanostomy tube placement." 01/01/1992 - "The findings reveal that patients manifesting eustachian tube dysfunction after their first HBO treatment were at significantly greater risk toward developing symptoms of fullness and serous otitis media, often requiring tympanostomy tube placement. " 03/01/2012 - "A considerable proportion of patients (45%) who had otitis media with effusion experienced a spontaneous resolution without the use of tympanostomy tubes 2 to 8 months after their operation. " 11/15/2015 - "Application of tympanostomy tube is effective in the treatment of serous otitis media resulting from ventilation disorder. "
2.	Adenoidectomy 11/01/1994 - "Herein, we present a single case of a pediatric patient with otitis media with effusion and manometrically proven active and passive Eustachian tube obstruction which was relieved by adenoidectomy. " 09/01/2001 - "Our findings demonstrate that both adenoidectomy and adenotonsillectomy are effective for the treatment of persistent otitis media with effusion, and they confirm the findings of other studies. " 10/15/1998 - "Adenoidectomy has been demonstrated in randomized controlled studies to be effective in the prevention of otitis media with effusion (OME). " 05/01/1994 - "The efficacy of adenoidectomy in the surgical treatment of children with otitis media with effusion (OME) persisting after adequate medical therapy has been established in three independent randomized clinical trials. " 03/20/1993 - "To measure the time to spontaneous resolution of severe chronic otitis media with effusion (glue ear) in children and study the effects of adenoidectomy, adenotonsillectomy, and ventilation tubes (grommets). "
3.	Lasers (Laser) 01/01/2014 - "The aim of this study was to evaluate the efficacy of laser myringotomy (LM) compared to ventilation tube (VT), and to assess the clinical success criteria of LM-assisted VT insertion as the flexible alternatives avoiding GA for the treatment of bilateral consistent otitis media with effusion (OME). " 10/01/2014 - "Middle ear effusion cleared in 44 out of 48 ears with laser myringotomy (LM) as compared to34 out of 50 ears with incisional myringotomy. " 12/01/2006 - "An otitis media with effusion model in human temporal bones with two laser vibrometers was created in this study. " 05/01/2004 - "Laser myringotomy versus ventilation tubes in children with otitis media with effusion: a randomized trial." 10/01/2014 - "Laser and incisional myringotomy in otitis media with effusion-a comparative study."
4.	Gas Lasers 01/01/1994 - "CO2 laser myringotomy has previously been proven effective in patients with serous otitis media for short-term aeration of the middle ear. " 01/01/2004 - "The efficacy of CO2 laser myringotomy in serous otitis media." 03/01/2006 - "The study aimed to evaluate the clinical application of CO2 laser myringotomy in children with otitis media with effusion (OME) under topical anaesthesia in an office setting. " 03/01/2006 - "CO2 laser myringotomy in children with otitis media with effusion." 04/01/2002 - "Ventilation time of the middle ear in otitis media with effusion (OME) after CO2 laser myringotomy."
5.	Oral Administration 01/01/2014 - "The purpose of this systematic review is to investigate the efficacy of the oral administration of herbal medicines for otitis media with effusion through analysing trial data. " 10/01/2014 - "We studied findings from middle ear effusion (MEE) samples after randomized, placebo-controlled 3-week oral administration of probiotic Lactobacillus rhamnosus GG (L. " 01/01/2014 - "Oral administration of herbal medicines for the treatment of otitis media with effusion: protocol for a systematic review." 09/01/1990 - "Oral administration of Mucodyn syrup is a suitable supplement of comprehensive treatment of children with secretory otitis media." 07/01/1994 - "Results of the study showed that the oral administration of S-CMC at a dose of 200 mg/kg of body weight is more effective than at a dose of 100 mg/kg in the clearance of middle ear effusions in experimental OME. "