Otitis Media

01/01/2011 - "Watchful waiting, followed by amoxicillin treatment, if necessary, is the best first-line treatment for acute otitis media in children aged six months or older."
12/01/1989 - "Amoxicillin is the standard of therapy for infants and children with acute otitis media, because it is safe and effective for most of the causative bacterial pathogens. "
08/01/2004 - "Developing community-specific recommendations for first-line treatment of acute otitis media: is high-dose amoxicillin necessary?"
05/01/2003 - "Bacteriologic and clinical efficacy of high dose amoxicillin for therapy of acute otitis media in children."
12/01/1986 - "Because reduction in division of the amoxicillin dose caused no significant difference in the efficacy of antibiotic treatment of acute otitis media in infants and children, we think that this simplified scheme of therapy can routinely be used in clinical practice and thus improve compliance to antibiotic administration."

10/21/2006 - "Antibiotics seem to be most beneficial in children younger than 2 years of age with bilateral acute otitis media, and in children with both acute otitis media and otorrhoea. "
12/01/1998 - "In most countries, acute otitis media in children is treated with antibiotics; however, the efficacy of antibiotic use in every acute otitis media is a controversial issue. "
12/01/1996 - "Critical review of the published evidence suggests that the most favorable outcomes from medical treatment will occur if practitioners: appreciate the favorable natural history of untreated otitis media realize that OME may take months to resolve following a single AOM episode modify risk factors to improve the odds of spontaneous resolution use pneumatic otoscopy and confirmatory tympanometry to diagnose OME recognize the limited impact of antibiotic therapy on treatment and prevention balance the benefits of antibiotics against the risk of accelerated bacterial resistance avoid repetitive, prolonged, or prophylactic antibiotic treatment of chronic OME avoid ineffective therapy, such as antihistamine/decongestant preparations An important aspect of management is helping caregivers understand the natural history of otitis media and the impact of medical treatment on shortterm and long-term outcomes. "
09/05/1977 - "This high incidence of Haemophilus isolation from the middle ear exudate of these children has important therapeutic implications; antibiotics effective against H influenzae should be employed when dealing with otitis media in this older age group."
01/01/2004 - "Health professionals showed a significantly greater knowledge about antibiotics and were less likely to expect antibiotics to be prescribed for acute otitis media than non-health professionals before using the website. "

09/01/2001 - "Bacteriologic and clinical efficacy of high dose amoxicillin/clavulanate in children with acute otitis media."
02/01/2001 - "The recommendation of the Drug-Resistant Streptococcus pneumoniae Therapeutic Working Group that high-dose amoxicillin, with or without clavulanate, be used to treat acute otitis media (AOM) addressed concerns about the efficacy of existing therapies against drug-resistant S. "
01/01/2013 - "If once or twice daily amoxicillin, with or without clavulanate, is as effective for acute otitis media as three or four times a day, it may be more convenient to give the medication once or twice a day to children and hence improve compliance. "
02/01/2000 - "amoxycillin/clavulanate is an effective treatment for pediatric acute otitis media and demonstrates that the b.d. "
05/01/1997 - "Efficacy of twice-daily dosing of amoxycillin/clavulanate in acute otitis media in children."

03/01/1981 - "In a study of the efficacy of pneumococcal capsular polysaccharide vaccines in preventing otitis media due to Streptococcus pneumoniae, 179 infants were randomly assigned to receive either a "target" vaccine containing serotypes 1, 3, 6, 7, 14, 18, 19, and 23 (which account for most cases of pneumococcal otitis media) or a control vaccine containing serotypes 2, 4, 5, 8, 9, 12, and 25 (which account for few cases). "
06/01/2001 - "This evolution should stimulate changes in the management of acute otitis media, particularly the following: improvement in diagnostic accuracy; reduction in antibiotic use; selection of the most appropriate drugs at the appropriate dosage; reduction in duration of treatment, when possible; and implementation of new vaccines."
04/01/2000 - "Vaccines against the major viruses predisposing to acute otitis media hold a great promise for the prevention of this disease. "
07/01/2009 - "New vaccines offering a larger spectrum of protection against acute otitis media: will parents be willing to have their children immunized?"
06/01/2009 - "New vaccines that offer protection against otitis media caused by nontypeable Haemophilus influenzae and by Moraxella catarrhalis are under development. "

08/01/1995 - "Improvement in signs and symptoms of otitis media occurred significantly more rapidly in the children treated with azithromycin. "
09/01/1996 - "Azithromycin is an effective, safe and well-tolerated treatment for children with acute otitis media."
08/01/2003 - "Efficacy of single-dose azithromycin in treatment of acute otitis media in children after a baseline tympanocentesis."
10/01/2005 - "A total of four clinical trials have evaluated the clinical success rate, safety and compliance of single-dose azithromycin (30 mg/kg) in the treatment of children with otitis media. "
02/01/2004 - "Three clinical trials have examined the efficacy and safety of single dose azithromycin (30 mg/kg) in children with uncomplicated acute otitis media (AOM). "

12/01/2004 - "Cefaclor therapy is very effective for treating children aged 2-6 years affected by acute otitis media, with no significant difference related to treatment duration. "
07/01/2001 - "The aim of this study was to evaluate the efficacy of cefaclor in the prophylaxis of recurrent acute otitis media (AOM) in human immunodeficiency virus (HIV)-infected children. "
12/01/2004 - "Clinical efficacy and tolerability of two different regimens of cefaclor were studied in 410 paediatric patients affected by non-recurrent acute otitis media (AOM). "
12/01/2004 - "[Clinical efficacy and tolerability of short course therapy with cefaclor compared with long-term therapy for treatment of acute otitis media in children]."
12/01/2003 - "In children with cefaclor SSLR, otitis media was the most common indication (59.4%), another 18.8% had viral illnesses. "

12/07/1991 - "To determine the efficacy of coamoxiclav in children aged 6 months to 12 years with recurrent acute otitis media. "
12/07/1991 - "Co-amoxiclav in recurrent acute otitis media: placebo controlled study."
01/01/2003 - "Amoxicillin/clavulanic acid: a review of its use in the management of paediatric patients with acute otitis media."
12/01/2002 - "In the intention to treat analysis the frequency of acute otitis media was 16.2% (16/99) in the placebo group and 9.6% (10/104) in the amoxicillin/clavulanic acid group (P = 0.288). "
12/07/1991 - "Co-amoxiclav has no significant benefit over placebo in treating children over 2 years with acute otitis media."

01/01/1995 - "Results obtained in this study suggest that ciprofloxacin locally administered is very effective in the treatment of chronic otitis media."
06/01/2014 - "In our study, topical ciprofloxacin therapy was found to be an effective treatment for an acute on chronic otitis media as was the combination therapy though the overall recurrence rate was found to be more in the former group. "
05/01/1990 - "The results of this preliminary study suggest that the use of topical ciprofloxacin is effective in curing chronic otitis media, even when it is caused by Pseudomonas (47% of the total bacterial detections)."
02/01/1997 - "From these preliminary results, topical ciprofloxacin appears to be effective in curing the acute phase of chronic otitis media."
01/01/1995 - "The aim of the present study was to assess the clinical and bacteriological efficacy of ciprofloxacin in the treatment of chronic otitis media. "

08/01/2003 - "Mucosal immunization of experimental animals with conjugate vaccines against Hib, pneumococcus, meningococcus and GBS induces systemic and mucosal immune responses, which provide protection against carriage, otitis media and invasive disease in a variety of challenge models, providing new means for protection against encapsulated bacteria. "
05/11/2009 - "How to compare the efficacy of conjugate vaccines to prevent acute otitis media?"
02/01/2001 - "Conjugate vaccines also provide protection against otitis media and may eliminate nasopharyngeal carriage of this organism. "
12/01/2015 - "This study investigated incidence and serotype distribution of Streptococcus pneumoniae causing acute otitis media (AOM) in Catalonian children, evaluating vaccination effectiveness in the current era of extended valency pneumococcal conjugate vaccines (PCVs). "
01/01/2012 - "Pneumococcal conjugate vaccines and otitis media: an appraisal of the clinical trials."

03/01/1994 - "The results of this study support the daily administration of cefixime as an effective agent for the treatment of otitis media due to its extended half-life and broad antibiotic spectrum."
01/01/1991 - "The results of this study demonstrate that cefixime is an effective and well tolerated treatment for acute otitis media in children."
01/01/1991 - "It was concluded that cefixime is clinically effective and well tolerated in the treatment of children with acute otitis media."
03/01/1994 - "An experimental study of cefixime in the treatment of Streptococcus pneumoniae otitis media."
01/01/1991 - "A large scale multicentre clinical study was undertaken to assess the efficacy and tolerability of cefixime in the treatment of acute otitis media in children. "

01/01/2012 - "Both follow-up through 2 years of age, for the 5 trials, and long-term follow-up, for PCV7-CRM/NCKP and PCV7-CRM/FinOM, demonstrated greater vaccine efficacy against recurrent AOM and tympanostomy-tube placement, suggesting that vaccination against early episodes of AOM may prevent subsequent episodes of complicated otitis media. "
07/01/2005 - "The chart-review cost analysis showed that tympanostomy tube insertion is a cost-effective treatment for otitis media in children, and the telephone survey results showed that it improves quality of life for children and their parents or other caregivers."
01/01/2000 - "It is suggested that severe injury to the middle ear mucosa caused TM adhesion during the process of wound healing, and that tympanostomy is effective in preventing adhesive otitis media."
10/01/1998 - "The objective of this study was to analyze the outcome of children receiving tympanostomy tubes with respect to improvement in hearing and incidence of otitis media. "
01/01/2015 - "Timing of Tympanostomy Tube Placement and Efficacy of Palatoplasty Technique on the Resolution of Chronic Otitis Media: A Cross-sectional Analysis."

10/01/2007 - "Tympanoplasty, with or without mastoidectomy, is highly effective for treatment of chronic otitis media in children."
09/01/2012 - "Tympanoplasty has been the mainstay of treatment in chronic otitis media. "
06/01/2007 - "Type III cartilage "shield" tympanoplasty is an effective technique for hearing improvement in selected patients with chronic otitis media. "
07/01/2015 - "Response to Comment on "Efficacy of Tympanoplasty Without Mastoidectomy on MRSA-infected Chronic Otitis Media"."
07/01/2015 - "Comment on "Efficacy of Tympanoplasty Without Mastoidectomy on MRSA-infected Chronic Otitis Media"."

10/01/1995 - "Adenoidectomy has been shown to be very effective in the treatment of chronic and recurrent otitis media. "
03/01/1976 - "Past studies of the efficacy of adenoidectomy in the management of children with otitis media have been inconclusive due to significant limitations in experimental design. "
09/08/1999 - "To test the efficacy of adenoidectomy and adenotonsillectomy in children with persistent or recurrent otitis media who had not previously undergone tube placement and to compare the relative efficacy of adenoidectomy alone vs adenotonsillectomy in such children. "
09/08/1999 - "Our study showed limited and short-term efficacy of both adenoidectomy and adenotonsillectomy; given the risks, morbidity, and costs of these procedures, these data suggest that neither operation should ordinarily be considered as a first surgical intervention in children whose only indication is recurrent acute otitis media."
05/01/1980 - "Data thus far collected in the study are not sufficient to reach a conclusion for or against the efficacy of adenoidectomy for otitis media, but it is apparent that adenoidectomy by no means eliminates the problem."

01/01/2015 - "The prognosis on tube-related simple chronic otitis media after myringoplasty, with the preserved continuity of the ossicular chain, consists of closing the ABG and leads to significant improvement of bone conduction."
02/01/1983 - "Simple mastoidectomy is considered to be a safe and effective adjunct to myringoplasty in selected cases of chronic otitis media with perforation."
01/01/2014 - "The objective of the present study was to estimate the regenerative potential of the tympanic membrane tissues in the early period of remission after experimental otitis media and evaluate the results of myringoplasty. "
01/01/2014 - "[The state of the regenerative activity of the tympanic membrane tissues and the results of myringoplasty at different time points of remission of experimental otitis media]."
12/01/2009 - "Myringoplasty is one of the various surgical techniques for the management of chronic supurative otitis media of tubotympanic type (CSOM-TT). "

04/01/2012 - "The incidence, clinical features, and optimal management of chronic otitis media (COM) in solid organ transplant recipients have not been adequately evaluated. "
02/05/2010 - "The aim of this study was to investigate a novel technique of perichondrium/cartilage composite graft for repairing the large TM perforation in the patient of otitis media. "
06/01/2015 - "To reveal the success of boomerang-shaped chondroperichondrial graft (BSCPG) in pediatric chronic otitis media cases. "
06/01/2015 - "Surgical success of boomerang-shaped chondroperichondrial graft in pediatric chronic otitis media cases."
10/01/2012 - "Vascularisation of myringo-/tympanoplastic grafts in active and inactive chronic mucosal otitis media: a prospective cohort study."