Otitis Media

10/21/2006 - "Antibiotics seem to be most beneficial in children younger than 2 years of age with bilateral acute otitis media, and in children with both acute otitis media and otorrhoea. "
12/01/1998 - "In most countries, acute otitis media in children is treated with antibiotics; however, the efficacy of antibiotic use in every acute otitis media is a controversial issue. "
09/05/1977 - "This high incidence of Haemophilus isolation from the middle ear exudate of these children has important therapeutic implications; antibiotics effective against H influenzae should be employed when dealing with otitis media in this older age group."
02/01/2021 - "A statistically significant reduction in the mean number of documented acute otitis media episodes, otorrhea episodes, and systemic antibiotic treatments during the February-April 2020 period compared with February-April 2019 was attested. "
01/01/2004 - "Health professionals showed a significantly greater knowledge about antibiotics and were less likely to expect antibiotics to be prescribed for acute otitis media than non-health professionals before using the website. "

09/01/2000 - "The most recent study, involving over 37,000 young children, also evaluated the vaccine's efficacy, and reported that the vaccine is highly effective in preventing invasive disease and has had an impact on otitis media. "
10/01/2004 - "Important questions have been raised regarding the effectiveness of this vaccine in high-risk populations, serotype replacement, the efficacy of this vaccine in otitis media, and the co-administration of the new vaccine with other standard childhood vaccines used in various European countries. "
03/01/1981 - "Thus, although the vaccine may be associated with a lower incidence of otitis media, the results of this study do not show a statistically significant efficacy of the vaccine."
06/01/2006 - "New candidate 9-valent vaccine proved significant reduction in overall morbidity in Gambia and 11-valent vaccine confirmed improved effect on acute otitis media."
12/31/2022 - " 33 articles, we found that:‡Both vaccines were effective in reducing doctor visits for otitis media as well as the number of severe cases and cases requiring hospitalization.‡Four studies suggested a higher level of protection provided by PHiD-CV compared to PCV13, although more data is needed to confirm this finding. "

01/01/2011 - "Watchful waiting, followed by amoxicillin treatment, if necessary, is the best first-line treatment for acute otitis media in children aged six months or older."
08/01/2004 - "Developing community-specific recommendations for first-line treatment of acute otitis media: is high-dose amoxicillin necessary?"
10/10/2023 - "What is Known: • Amoxicillin given in two daily doses is as effective as a three doses regimen in the treatment of acute otitis media in children. "
09/01/2010 - "Amoxicillin may be cost effective in treating children with acute otitis media. "
09/01/2021 - "Although guidelines in many countries recommend amoxicillin as the first-line treatment for acute otitis media, the prescribing pattern in Japan is not clear. "

01/01/2008 - "We report the phase III trial efficacy of 7-valent pneumococcal conjugate vaccine against clinical and culture proven otitis media (OM) among Navajo and White Mountain Apache infants. "
01/01/2017 - "Furthermore, the unsatisfactory protection offered by the pneumococcal conjugate vaccines is highlighted and we review potential future strategies emerging to confer a more specific protection against otitis media."
12/01/2016 - "This new Hib-PsaA conjugate vaccine can induce both anti-PsaA and anti-Hib immune responses in young mice and elicit effective protection against acute otitis media caused by pneumococcus."
08/01/2003 - "Mucosal immunization of experimental animals with conjugate vaccines against Hib, pneumococcus, meningococcus and GBS induces systemic and mucosal immune responses, which provide protection against carriage, otitis media and invasive disease in a variety of challenge models, providing new means for protection against encapsulated bacteria. "
12/01/2006 - "(5) The efficacy of the 7-valent pneumococcal conjugate vaccine in the prevention of acute otitis media in infants has been tested in several clinical trials: it is minimal to non-existent. "

01/01/2018 - "Erratum for Hoberman et al., "Reduced-Concentration Clavulanate for Young Children with Acute Otitis Media"."
01/01/2017 - "Reduced-Concentration Clavulanate for Young Children with Acute Otitis Media."
12/13/2013 - "If once or twice daily amoxicillin, with or without clavulanate, is as effective for acute otitis media as three or four times a day, it may be more convenient to give the medication once or twice a day to children and hence improve compliance. "
02/01/2000 - "amoxycillin/clavulanate is an effective treatment for pediatric acute otitis media and demonstrates that the b.d. "
01/01/2023 - "Efficacy of antimicrobials or placebo compared to amoxicillin-clavulanate in children with acute otitis media: a systematic review."

01/01/2022 - "The identified protein gives a platform for the discovery of a lead drug candidate that may inhibit it and may help to eradicate the otitis media caused by drug-resistant M. "
01/01/2018 - "Haemophilus influenzae-protein D specific antibody correlate with protection against acute otitis media in young children."
11/01/1997 - "Detoxified lipooligosaccharide from nontypeable Haemophilus influenzae conjugated to proteins confers protection against otitis media in chinchillas."
01/01/2018 - "The objective of this study was to assess the correlation of NP colonization-induced serum antibody levels to Hi protein D with risk of acute otitis media (AOM) in children <2 yr. "
05/01/2020 - "And Spag6 protein is distributed in different genotypes of mouse hair cells; Spag-/- mice showed otitis media. "

01/01/1995 - "Results obtained in this study suggest that ciprofloxacin locally administered is very effective in the treatment of chronic otitis media."
05/01/1990 - "The results of this preliminary study suggest that the use of topical ciprofloxacin is effective in curing chronic otitis media, even when it is caused by Pseudomonas (47% of the total bacterial detections)."
02/01/1997 - "From these preliminary results, topical ciprofloxacin appears to be effective in curing the acute phase of chronic otitis media."
01/01/1995 - "The aim of the present study was to assess the clinical and bacteriological efficacy of ciprofloxacin in the treatment of chronic otitis media. "
12/01/1995 - "In the ciprofloxacin group, 21 (88%) of the 24 patients with suppurative chronic otitis media were cured. "

03/01/2005 - "In conclusion, cefaclor is a well tolerated and effective antibacterial option for acute otitis media in children and it is superior to the combination of amoxicillin+clav in efficacy and tolerability in acute AOM. "
07/01/2001 - "The aim of this study was to evaluate the efficacy of cefaclor in the prophylaxis of recurrent acute otitis media (AOM) in human immunodeficiency virus (HIV)-infected children. "
03/01/2005 - "Present study is designed as a multicentric prospective trial to study and compare the efficacy and safety of cefaclor versus amoxicillin+clav in children with acute otitis media. "
12/01/2004 - "Clinical efficacy and tolerability of two different regimens of cefaclor were studied in 410 paediatric patients affected by non-recurrent acute otitis media (AOM). "
12/01/2003 - "In children with cefaclor SSLR, otitis media was the most common indication (59.4%), another 18.8% had viral illnesses. "

05/01/1980 - "These findings suggest that vaccination with pneumococcal capsular polysaccharide may be effective for preventing type-specific pneumococcal otitis media in infants and young children."
02/06/2006 - "We tested the clinical efficacy of combined pneumococcal conjugate and pneumococcal polysaccharide vaccination according to FcgammaIIa-H/R131 genotype in a randomized double blind placebo controlled vaccination trial in children with a history of acute otitis media. "
10/01/2021 - "Die Periodische Säure Schiff Färbung (PAS) kann Polysaccharide EPS bei der humanen Otitis media mit Effusion färben, was allerdings bei der OE des Hundes noch nicht versucht wurde. "
01/01/2021 - "Serum antibody levels to pneumococcal polysaccharides 22F, 33F, 19A and 6A that correlate with protection from colonization and acute otitis media in children."
05/21/2009 - "Pneumococcal serotype 3 otitis media, limited effect of polysaccharide conjugate immunisation and strain characteristics."

01/01/1991 - "The results of this study demonstrate that cefixime is an effective and well tolerated treatment for acute otitis media in children."
01/01/1991 - "It was concluded that cefixime is clinically effective and well tolerated in the treatment of children with acute otitis media."
01/01/1993 - "Efficacy of cefixime in the treatment of acute otitis media in children."
03/01/1994 - "An experimental study of cefixime in the treatment of Streptococcus pneumoniae otitis media."
04/01/1987 - "The results of this study warrant the testing of cefixime for acute otitis media in the clinical setting."

10/01/1991 - "While otitis media is perhaps the most common disease of childhood that receives medical attention, there is little agreement concerning the efficacy of the medical and surgical therapies employed to try to alleviate its symptoms or hasten its natural resolution. "
11/01/1988 - "Otitis media, the diagnosis most frequently made by the pediatrician, is most effectively treated with antimicrobial therapy. "
01/01/2012 - "bovis otitis media is an economically important problem, there is a need to understand the pathogenesis of disease, not only to improve our understanding of the factors contributing to the development of this disease but also to inform the development of improved diagnostic tests and therapy. "
11/01/2011 - "Since respiratory viruses were detected frequently in the nasopharynx of both children with and without a history of recurrent acute otitis media, the etiological role of specific viruses in recurrent acute otitis media remains uncertain, however, anti-viral therapies may be beneficial in future treatment and prevention strategies for acute otitis media."
12/08/2000 - "Surgical therapy of otitis media offers significant benefits and is an effective prevention strategy in selected children."

07/01/2014 - "The use of ossicular graft material in ossicular chain reconstruction has significantly improved hearing results hearing after tympanoplasty and tympanomastoid surgery for chronic otitis media. "
12/01/1998 - "Improvement in hearing after the operation was observed in 90% of the cases and the improvement was relatively high compared with tympanoplasty for chronic otitis media."
10/01/2019 - "Tympanoplasty combined with fascia grafting catheterization is effective in the treatment of adhesive otitis media."
09/01/2012 - "Tympanoplasty has been the mainstay of treatment in chronic otitis media. "
06/01/2007 - "Type III cartilage "shield" tympanoplasty is an effective technique for hearing improvement in selected patients with chronic otitis media. "

07/01/2005 - "The chart-review cost analysis showed that tympanostomy tube insertion is a cost-effective treatment for otitis media in children, and the telephone survey results showed that it improves quality of life for children and their parents or other caregivers."
01/01/2000 - "It is suggested that severe injury to the middle ear mucosa caused TM adhesion during the process of wound healing, and that tympanostomy is effective in preventing adhesive otitis media."
03/01/2020 - "Objective:To evaluate the short-term and long-term efficacy of balloon dilatation Eustachian tuboplasty（BET） and insertion of tympanostomy tubes in the treatment of recurrent otitis media with effusion（OME） in children, and to provide new ideas for the treatment of OME. "
10/01/1998 - "The objective of this study was to analyze the outcome of children receiving tympanostomy tubes with respect to improvement in hearing and incidence of otitis media. "
01/01/2015 - "Timing of Tympanostomy Tube Placement and Efficacy of Palatoplasty Technique on the Resolution of Chronic Otitis Media: A Cross-sectional Analysis."

08/01/2007 - "This study has been conducted in order to analyze the outcomes of a previously described technique for chronic otitis media surgery: the improved radical mastoidectomy with flap (formerly IRMF), which consisted of improved radical mastoidectomy (formerly IRM), inferiorly based fascioperiosteal flap and large meatoconchoplasty (Kahramanyol, Ear Nose Throat J 71:70-77, 1992; Kahramanyol et al., Ear Nose Throat J 79:524-526, 2000). "
06/16/2023 - "However, the structure of the middle ear is often altered in patients who undergo mastoidectomy or posterior wall removal for refractory otitis media, leaving uncertainty regarding the efficacy of hearing devices. "
04/01/2023 - "Surgical Efficacy of Mastoidectomy in Chronic Otitis Media: Squamosal Type."
02/05/2010 - "The hearing was improved even if the mastoidectomy was required in the patients with otitis media with extensive granulation."
02/01/2006 - "To evaluate clinical and audiologic data as well as operative findings and postoperative follow-up in the management of chronic cholesteatomatous otitis media with canal wall down mastoidectomy (CWDM). "

10/01/1995 - "Adenoidectomy has been shown to be very effective in the treatment of chronic and recurrent otitis media. "
03/01/1976 - "Past studies of the efficacy of adenoidectomy in the management of children with otitis media have been inconclusive due to significant limitations in experimental design. "
09/08/1999 - "To test the efficacy of adenoidectomy and adenotonsillectomy in children with persistent or recurrent otitis media who had not previously undergone tube placement and to compare the relative efficacy of adenoidectomy alone vs adenotonsillectomy in such children. "
09/08/1999 - "Our study showed limited and short-term efficacy of both adenoidectomy and adenotonsillectomy; given the risks, morbidity, and costs of these procedures, these data suggest that neither operation should ordinarily be considered as a first surgical intervention in children whose only indication is recurrent acute otitis media."
05/01/1980 - "Data thus far collected in the study are not sufficient to reach a conclusion for or against the efficacy of adenoidectomy for otitis media, but it is apparent that adenoidectomy by no means eliminates the problem."