Osteosclerosis

01/01/2022 - "Marrow biopsy at 12 months showed clearance of marrow reticulin, improvement of osteosclerosis and normalization of bone trabeculae, cellularity and myelopoiesis. "
09/19/1981 - "At bone biopsy, various aspects of panhyperplasia, increase in the reticular fibers, myeloid fibrosis and osteosclerosis were observed. "
08/01/2011 - "CT scanning displayed femoral cortical thickening, medulla canal narrowing and lumbar spine density increasing at day 150, meanwhile, HE staining and reticular fiber staining showed the fatty degeneration or vacuolization in liver, splenomegaly with megakaryocytic proliferation, femur bone marrow fibrosis and osteosclerosis. "
01/01/2000 - "A trephine biopsy showed a hypercellular bone marrow with a proliferation of abnormal megakaryocytes, mild reticulin fibrosis, and osteosclerosis, i.e., features of an early stage of idiopathic myelofibrosis. "
01/01/1975 - "The pathological features of the osteomyleoproliferative syndrome development were studied by trephine biopsy on 32 cases out of which 28, lesionally characterized by myeloproliferation, reticulin hyperplasia, intravascular hematopoiesis, myelofibrosis, myeloslerosis, and osteosclerosis, were interpreted as primary osteomyelosclerosis. "

10/14/2020 - "CALR-mutated patients had increased dense clusters and giant sizes of megakaryocytes, collagen, and osteosclerosis(P=0.055, P=0.059, P=0.011, P=0.046). "
05/01/2016 - "Furthermore, we propose a minor modification of the current grading and separate scoring for collagen deposition and osteosclerosis. "
05/01/2016 - "Therefore, additional assessment of collagen and the grade of osteosclerosis appear to be essential to discriminate all components of the complex BM fibrous matrix. "
05/01/2015 - "Additional assessment of collagen deposition and osteosclerosis may further increase diagnostic and prognostic precision. "
04/01/2004 - "Both individuals had severe osteosclerosis, and their biopsies displayed multinucleated osteoclasts apposed to areas of demineralized matrix as well as bone-lining cells adjacent to this undigested collagen left over by osteoclasts. "

01/01/2013 - "Common radiographic features in patients taking bisphosphonate, was osteosclerosis. "
09/01/2010 - "These data support the need to better understand radiographic features associated with bisphosphonate exposure and to determine whether osteosclerosis is a specific finding indicative of the risk for progression to BRONJ."
10/01/2008 - "Bisphosphonate-induced osteopetrosis: novel bone modeling defects, metaphyseal osteopenia, and osteosclerosis fractures after drug exposure ceases."
01/01/2004 - "Despite the fact that osseous metastases in prostate cancer manifest as osteosclerosis rather than osteolysis, studies now show that bisphosphonates are useful in the management of this disease. "
11/01/2023 - "Additionally, patients given bisphosphonates showed considerably more osteosclerosis than those given denosumab. "

12/01/1978 - "The loss of natural killing may reflect a loss of bone marrow secondary to estrogen-induced osteosclerosis."
05/01/1977 - " The osteosclerosis is due to an effect of estrogens to reduce osteoclast numbers and a lesser inhibitory effect on the bone-forming activity of osteoblasts and osteocytes."
05/01/1977 - " In rats treated with estrogens, osteosclerosis of the tibial metaphysis developed after 8 days. "
05/01/1977 - "After 8 days, an osteosclerosis of the tibial metaphysis developed in rats treated with estrogens. "
11/01/1976 - "Pharmacological doses of estrogens induce osteosclerosis of the bone marrow, and depress colony-forming units (CFU's) and platelet and leukocyte counts in mice. "

11/01/2018 - "Spontaneous resolution of metaphyseal osteosclerosis occurred while biochemical markers indicated active bone turnover. "
01/01/2023 - "To investigate the potential association between cytokine and bone remodeling markers with bone disease in SM, aiming at identifying biomarker profiles associated with bone loss and/or osteosclerosis. "

01/01/2016 - "Triphasic 99mTc methylene diphosphonate (MDP) Bone scan helped in confirming the diagnosis of intramedullary osteosclerosis, a dysplastic bone disorder. "
06/21/2022 - "A 99mTc-MDP bone scrintigraphy scan revealed symmetrical increased uptake in distal femoral and proximal tibial metaphysis, which was confirmed to be osteosclerosis by high-resolution peripheral quantitative computed tomography. "

01/01/2021 - "Importantly, ovariectomized female Mpig6b-/- mice also demonstrated improvement in spleen weight compared to sham-operated Mpig6b-/- mice, establishing estrogen as a contributing factor to the severity of the megakaryocyte-driven osteosclerosis. "
08/01/2010 - "Zoledronic acid induced a marked osteosclerosis in the primary spongiosa in both SHAM and rats inoculated with MLL. "

04/01/1997 - "Osteopetrotic (op/op) mice show severe osteosclerosis caused by an inherited deficiency of osteoclast and resultant failure of tooth eruption, which can be cured by the injection of macrophage colony-stimulating factor (M-CSF). "

08/01/2011 - "A case of hepatitis C-associated osteosclerosis that was improved with the combination therapy of peginterferon alfa-2b and ribavirin."

08/01/2011 - "A case of hepatitis C-associated osteosclerosis that was improved with the combination therapy of peginterferon alfa-2b and ribavirin."

05/01/2001 - "Radiography showed that osteolytic changes (evident from 'moth-eaten' appearance of bone) had improved but that osteosclerosis had persisted or become more predominant by the end of therapy. "
11/01/2007 - "Such genetic disorders can be attributed either to osteoclast deficiencies, collectively termed "osteopetrosis," or to intrinsically elevated osteoblast activity, termed "osteosclerosis." However, an increasing need for anabolic therapies to prevent age-induced bone loss has stimulated a search for additional genes that act at the level of the osteoblast to regulate matrix synthesis. "
12/01/1996 - "Osteosclerosis is a rare complication of hepatitis C infection, the symptoms of which are controllable with diphosphonate therapy."
08/01/1996 - "At 30 days after therapy bone marrow and spleen of mice treated with AdCMV.TPO were populated with a large number of polyploid megakaryocytes, but there was no evidence of circulating megakaryocytes in the liver or lungs and no pathologic bone abnormalities such as osteosclerosis or myelofibrosis. "
12/01/1999 - "Whereas originally features of vitamin D deficiency (rickets/osteomalacia) and secondary hyperparathroidism (erosions, osteosclerosis, brown cysts) predominated, improvement in management and therapy have resulted in such readiographic features being present in a minority of patients. "

10/01/1982 - "Severe marrow fibrosis and osteosclerosis gradually disappeared after a 33-year-old woman received an allogeneic bone marrow transplantation (BMT) as experimental treatment for chronic granulocytic leukaemia. "
10/01/1982 - "Reversal of severe bone marrow fibrosis and osteosclerosis following allogeneic bone marrow transplantation for chronic granulocytic leukaemia."
09/18/1982 - "In one patient severe myelofibrosis and osteosclerosis disappeared after bone-marrow transplantation. "
07/15/1996 - "A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): reversal of disease by bone marrow transplantation."
10/01/1982 - "In this case severe marrow infiltration with reticulin and collagen fibrosis as well as severe derangement of marrow architecture and obliteration of the medullary cavity by osteosclerosis was an entirely reversible process after allogeneic bone marrow transplantation, and did not prevent successful engraftment, haemopoietic and cytogenetic reconstitution and complete remission from chronic granulocytic leukaemia."

09/01/1995 - "Primary plasma cell leukemia with extensive dense osteosclerosis: complete remission following combination chemotherapy."

12/01/2010 - "Although the reason for this difference in the healing patterns remains unknown, this study indicates the majority of the hips showed osteosclerosis after a transtrochanteric rotational osteotomy, while approximately 30% of the hips showed a normal bony architecture."
01/01/2003 - "The Medial/Lateral ratio of osteosclerosis decreased rapidly within three years after osteotomy at the reference points of the femur and the tibia. "
01/01/2003 - "Decrease of osteosclerosis in subchondral bone of medial compartmental osteoarthritic knee seven to nineteen years after high tibial valgus osteotomy."
01/01/1997 - "Changes in osteosclerosis of the osteoarthritic knee after high tibial osteotomy."
01/01/2003 - "Osteosclerosis of the subchondral bone was measured by densitometer on plain radiographs in 55 medial compartmental osteoarthritic knees of 40 patients who were treated with high tibial valgus osteotomy for correction of varus deformity. "

04/20/1991 - "The most severe histological forms of OM were found in hemodialysis patients with persistent hypophosphoremia and associated with osteosclerosis."
07/16/1978 - "[Diffuse osteosclerosis complicating hemodialysis]."
04/01/1997 - "In this study, we investigated the relationship between the concentrations of intact parathyroid hormone (i-PTH) and midregion PTH (m-PTH) measured by an immunoradiometric assay and a radioimmunoassay, respectively, versus various demographic and biochemical parameters, bone mineral density (BMD) of the lumbar spine (LS) and radius, and the radiographic findings of osteosclerosis and aortic calcification in hemodialysis (HD) patients. "