Osteoradionecrosis

01/01/2018 - "Re: Pentoxifylline: a review of its use in osteoradionecrosis."
04/01/2017 - "Pentoxifylline - a review of its use in osteoradionecrosis."
11/01/2004 - "The efficacy of combined pentoxifylline-tocopherol treatment in superficial RIF was confirmed in a randomised clinical trial, and then in successful phase II trials especially in uterine fibroatrophy and osteoradionecrosis. "
06/01/2021 - "Pentoxifylline, tocopherol, and sequestrectomy are effective for the management of advanced osteoradionecrosis of the jaws-a case series."
11/01/2019 - "Interest in pentoxifylline and tocopherol is growing because these agents have been shown to be effective in treating osteoradionecrosis of the jaw. "

02/01/2020 - "The purpose of this study was to investigate the effect of PTX and tocopherol in patients diagnosed with osteoradionecrosis (ORN), bisphosphonate-related osteonecrosis of the jaw (BRONJ), and chronic osteomyelitis using digital panoramic radiographs. "
11/01/2004 - "The efficacy of combined pentoxifylline-tocopherol treatment in superficial RIF was confirmed in a randomised clinical trial, and then in successful phase II trials especially in uterine fibroatrophy and osteoradionecrosis. "
06/01/2021 - "Pentoxifylline, tocopherol, and sequestrectomy are effective for the management of advanced osteoradionecrosis of the jaws-a case series."
11/01/2019 - "Interest in pentoxifylline and tocopherol is growing because these agents have been shown to be effective in treating osteoradionecrosis of the jaw. "
06/01/2021 - "The aim of the present study was to evaluate the efficacy of pentoxifylline and tocopherol for the management of osteoradionecrosis of the jaws. "

11/01/2017 - "Surgical treatment can be an effective treatment for temporal bone osteoradionecrosis, without hyperbaric oxygen providing any additional benefit. "
03/01/2011 - "Based on weak evidence, prophylactic hyperbaric oxygen is effective in reducing the risk of developing osteoradionecrosis after post-radiation extractions."
01/01/2022 - "Hyperbaric oxygen treatment of mandibular osteoradionecrosis: Combined data from the two randomized clinical trials DAHANCA-21 and NWHHT2009-1."
12/01/2021 - "This study was performed to investigate the effects of hyperbaric oxygen and other approaches for treating the osteoradionecrosis of the jaws (ORNJ) systematically. "
01/10/2018 - "The HOPON trial is the only multi-centre RCT conducted in this clinical setting despite decades of use of hyperbaric oxygen for the prevention of osteoradionecrosis. "

12/01/2015 - "Pentoxifylline-tocopherol-clodronate combination: A novel treatment for osteoradionecrosis of the temporal bone."
11/01/2020 - "Efficacy of pentoxifylline-tocopherol-clodronate in mandibular osteoradionecrosis."
12/01/2014 - "The objectives of this study were to evaluate the efficacy and safety of PENTOCLO to treat osteoradionecrosis of the mandible. "
07/01/2011 - "Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a phase II trial."
01/01/2023 - "Comments on Dinnoo et al., 2021: ''18F-FDG PET/CT for early response assessment of jaw osteoradionecrosis after the PENTOCLO protocol: A promising imaging modality''."

01/01/2019 - "Protocol for prospective randomised assessor-blinded pilot study comparing hyperbaric oxygen therapy with PENtoxifylline+TOcopherol± CLOdronate for the management of early osteoradionecrosis of the mandible."
01/01/2018 - "The combination of pentoxifylline plus tocopherol with or without clodronate was found to be effective for the treatment of mandibular osteoradionecrosis, although data were generally scarce and mostly came from retrospective case series. "
11/01/2021 - "One relatively well-established method of treating osteoradionecrosis includes the PENTOCLO protocol, which consists of Pentoxyllifylline, Tocopherol, and Clodronate. "
01/01/2021 - "The use of pentoxifylline, tocopherol and clodronate in the management of osteoradionecrosis of the jaws."
01/01/2018 - "We searched for relevant reports in PubMed by using a combination of "osteoradionecrosis" and the following keywords: "pentoxifillyne," "tocopherol," "vitamin E," or "clodronate." We considered articles in English or Spanish, with no limitations on the publication date. "

07/04/2023 - "To report the microorganisms and their antibiotic sensitivity profile from tissue cultures and stains at the time of anterolateral thigh fascia lata (ALTFL) rescue flap for management of mandibular osteoradionecrosis (ORN). "
06/01/2003 - "Only 40% of patients with osteoradionecrosis could be healed completely by means of surgery and antibiotic medication. "
12/01/1973 - "[3 cases of osteoradionecrosis of the mandible treated with antibiotics with or without gammaglobulins]."
01/01/1986 - "Conventional treatment of osteoradionecrosis of mandible is by antibiotics combined if necessary with a hemimandibulectomy. "
01/01/2019 - "Conservative management of osteoradionecrosis (antibiotics, debridement) costs $4000-$35 000, although estimates as high as $74 000 have been reported. "

11/01/2014 - "Because irradiation may cause osteoradionecrosis, antioxidant supplementation is often used to suppress irradiation-mediated injury. "
07/13/2023 - "Previous studies have shown that pentoxifylline combined with tocopherol proved to be beneficial in patients with osteoradionecrosis, due to their antioxidant and antifibrotic properties. "
01/01/2018 - "The purpose of this study was to evaluate the healing benefit provided by the antioxidant and antifibrotic properties of pentoxifylline-tocopherol or pentoxifylline-tocopherol-clodronate in combination therapy for osteoradionecrosis. "

04/01/2016 - "The aim of the study was to establish the long term efficacy of a perioperative antibiotic protocol combined with antibacterial mouthwashes in preventing osteoradionecrosis (ORN). "
05/01/2017 - "The aim of this study was to investigate the association of different dental prophylactic modalities and osteoradionecrosis (ORN) and determine the risk of ORN under different timing periods of scaling, with the use chlorhexidine mouth rinse after surgery and with different strategies of fluoride gel application in head and neck cancer (HNC) participants. "

07/01/2019 - "Influence of bisphosphonates on clinical features of osteoradionecrosis of the maxilla and mandible."
03/01/2018 - "Nine of the top 20 most cited articles and 12.5% of all the most cited papers were related to osteoradionecrosis, osteochemonecrosis, and bisphosphonates. "
09/01/2013 - "Bisphosphonate-induced osteoradionecrosis."
08/01/2008 - "An increasing number of reports have associated the use of bisphosphonates with the occurrence of osteoradionecrosis of the jaw. "
05/01/2007 - "Of the 2 cases of ONJ in bisphosphonate-naïve patients, osteoradionecrosis was clearly incriminated in 1 patient and potentially the causative factor in the other patient as well. "

01/01/2015 - "Hydrogen-rich saline may be an effective and specific novel treatment for osteoradionecrosis of the jaw."
01/01/2015 - "We hypothesized that hydrogen-rich saline might be an effective and specific method of managing and preventing osteoradionecrosis of the jaw. "

12/15/2018 - "At 6 months after operation, the mouth opening hardly improved in 2 patients who had osteoradionecrosis; 1 patient who underwent postoperative radiotherapy had restriction of mouth opening; the remaining 8 patients had normal month opening and normal diet. "
09/01/2023 - "These descriptive systematic reviews/meta-analyses included a total of 25 randomized clinical trials, showing that radiotherapy has positive effects on the frequency of osteoradionecrosis. "
07/14/2021 - "The objective of this study was to determine the predictors of osteoradionecrosis (ORN) which were associated with a dental extraction post radiotherapy. "
07/10/2013 - "The aim of the study was to develop a model for irradiation of the rabbit mandible in order to have a better knowledge of radiotherapy-induced bone alterations and thus a better prevention and treatment of osteoradionecrosis. "
06/01/2007 - "This study was done to determine if pre-radiotherapy (pre-RT) dental extractions reduce the risk of osteoradionecrosis (ORN). "

04/01/1990 - "The adequate utilization of hyperbaric oxygen therapy has been shown to be 95% effective in preventing osteoradionecrosis in postirradiated tissues."
11/01/2004 - "Hyperbaric oxygen therapy is a safe and effective treatment modality offering durable relief in the management of radiation-induced osteoradionecrosis either alone or as an adjunctive treatment. "
10/01/2003 - "This study was designed to use our institutional experience with irradiated head and neck patients to evaluate 1) dental extraction incidence and sequelae; 2) those patients who developed osteoradionecrosis via extraction and the efficacy of hyperbaric oxygen therapy; and 3) guidelines for extraction protocols in this population. "
01/01/2018 - "Efficacy of Adjunctive Hyperbaric Oxygen Therapy in Osteoradionecrosis."
04/01/2017 - "The efficacy of hyperbaric oxygen therapy related to the clinical stage of osteoradionecrosis of the mandible."

06/01/1986 - "Osteoradionecrosis of the mandible is extremely recalcitrant to conventional therapy, but aggressive surgery and treatment have proven effective."
12/01/2020 - "Mesenchymal Stem Cell Therapy for Osteoradionecrosis of the Mandible: a Systematic Review of Preclinical and Human Studies."
10/01/2013 - "Despite the observation in prior studies of minimal vessel damage in this setting, the hypothesis of this study is that in the late setting of most salvage surgical therapy, either for recurrence or osteoradionecrosis, a different, progressive level of vessel injury may be encountered. "
02/01/2023 - "Moreover, the article has considered the management option in a developing nation thus explaining the procedural as well as the financial pitfalls and has highlighted the potential loop holes to be addressed in the management of osteoradionecrosis with stem cell therapy."
02/01/2023 - "Mesenchymal stem cell therapy for treatment of osteoradionecrosis of mandible in head and neck surgery patients - A way forward into the future with promising clinical Outcomes."

12/01/2015 - "We concluded that fibular osteocutaneous free flap can be performed safely in patients with osteoradionecrosis and yields positive outcomes with significantly increased success rate. "
01/01/2020 - "The aim of this study was to investigate whether there has been an increase in free flap reconstruction due to osteoradionecrosis (ORN). "
04/01/2017 - "This study aimed to compare the cost of free-flap reconstructive surgery for grade III osteoradionecrosis and similar non-osteoradionecrosis cases in order to assess the cost burden of osteoradionecrosis treatment. "
09/01/2016 - "The objective was to trial the use of the Integra skin regeneration system intraorally to promote healing of an intraoral defect in osteoradionecrosis (ORN), thereby avoiding the necessity for mucosal flaps, free flaps, or skin grafts. "
06/01/2011 - "The purpose of this study was to evaluate outcomes of free flap reconstruction for advanced osteoradionecrosis (ORN) defects and develop an algorithm to guide surgical planning. "

11/01/2020 - "Osteoradionecrosis of the jaw can be treated using both conservative treatment and surgery. "
05/01/2020 - "Osteoradionecrosis of the Maxilla: Conservative Management and Reconstructive Considerations."
11/01/2016 - "New perspectives on the conservative management of osteoradionecrosis of the mandible: A literature review."
09/01/2012 - "Once osteoradionecrosis of the mandible has been established, conservative therapy is often useless. "
01/01/2012 - "Massive osteoradionecrosis in temporal bone responded unfavorably to conservative treatment, compared to that, surgery can effectively control the expansion of the lesion and markedly improve patient quality of life. "