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Osteonecrosis (Kienbock's Disease)

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Death of a bone or part of a bone, either atraumatic or posttraumatic.

Also Known As:

Kienbock's Disease; Kienbock Disease; Kienboeck Disease; Kienboeck's Disease; Bone Aseptic Necrosis; Bone Avascular Necrosis; Kienboecks Disease; Osteonecroses; Aseptic Necrosis of Bone; Avascular Necrosis of Bone; Necrosis, Aseptic, of Bone; Necrosis, Avascular, of Bone

Networked: 3149 relevant articles (112 outcomes, 363 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Osteoarthritis
2.	Pain (Aches)
3.	Infection
4.	Sickle Cell Anemia (Hemoglobin S Disease)
5.	Joint Diseases (Joint Disease)

Experts

1.	Mont, Michael A: 28 articles (10/2015 - 04/2002)
2.	Yamamoto, Takuaki: 22 articles (12/2015 - 10/2004)
3.	Iwamoto, Yukihide: 22 articles (12/2015 - 10/2004)
4.	Otto, Sven: 19 articles (08/2015 - 03/2009)
5.	Vescovi, Paolo: 18 articles (08/2015 - 12/2007)
6.	Glueck, Charles J: 17 articles (12/2015 - 04/2003)
7.	Motomura, Goro: 17 articles (12/2015 - 10/2004)
8.	Wang, Ping: 16 articles (12/2015 - 04/2003)
9.	Pautke, Christoph: 16 articles (07/2015 - 01/2010)
10.	Kubo, Toshikazu: 15 articles (07/2015 - 01/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Osteonecrosis:

1.	DiphosphonatesIBA 05/01/2015 - "Despite the widespread use of bisphosphonates and their unequivocal efficacy for the treatment of various disease states, osteonecrosis of the jaw remains one of the most feared complications associated with their use. " 12/01/2008 - "The use of bisphosphonates (BPs) has proven effective in the treatment of bone-related diseases, despite the potential risk of developing osteonecrosis of the jaw (ONJ). " 12/01/2007 - "The management of bisphosphonates osteonecrosis of the jaws presents a challenge to dentists as there is no effective treatment for this condition. " 12/01/2015 - "The aim of this study was to evaluate the knowledge of Brazilian dentists (DEN) and dental students (DS) about bisphosphonates (BP) and bisphosphonate-related osteonecrosis of the jaw (BRONJ). " 01/01/2015 - "To test the hypothesis that a proportion of patients with ONJ remain undiagnosed because their symptoms do not conform to the traditional case definition, we did a secondary analysis of data from MISSION (Multicentre study on phenotype, definition and classification of osteonecrosis of the jaws associated with bisphosphonates), a cross-sectional study of a large population of patients with bisphosphonate-associated ONJ who were recruited in 13 European centres. "
2.	zoledronic acid (zoledronate)FDA Link 09/01/2015 - "There is still controversy about the best treatment strategy for patients with bisphosphonate-related osteonecrosis of the jaw (BRONJ) stage I. Therefore, the aim of the present study was to analyse the effect of a nonsurgical treatment protocol in patients with BRONJ stage I. During the study period we included 17 patients (11 male; 6 female) who presented with a total of 24 separate areas of BRONJ, stage I. All patients were exclusively treated with a monthly intravenous regime of zoledronic acid due to an underlying malignant disease. " 12/01/2007 - "Possible delayed onset of osteonecrosis of the jaw in association with zoledronic acid." 07/20/2013 - "Osteonecrosis of the jaw and oral health-related quality of life after adjuvant zoledronic acid: an adjuvant zoledronic acid to reduce recurrence trial subprotocol (BIG01/04)." 11/01/2010 - "The incidence of osteonecrosis of the jaw in patients receiving 5 milligrams of zoledronic acid: data from the health outcomes and reduced incidence with zoledronic acid once yearly clinical trials program." 09/15/2009 - "The increasing incidence of osteonecrosis of the jaw and its possible association with high cumulative doses of bisphosphonate led us to study the effects of high doses of zoledronic acid (ZA) on bone remodeling. "
3.	OxygenIBA 12/09/2008 - "[Quantitative study of therapeutic efficacy on early intervention of hyperbaric oxygen to model of steroid-induced avascular osteonecrosis of femoral head by multi-slice perfusion imaging]." 03/01/2015 - "The authors concluded that hyperbaric oxygen treatment is effective in preserving the hip joint in stage I and II osteonecrosis of the femoral head." 12/09/2008 - "To quantitatively evaluate the hemodynamic status in animal models of steroid-induced avascular osteonecrosis of femoral head (SANFH) by multislice CT (MSCT) perfusion imaging, and estimate the therapeutic efficacy on early intervention of hyperbaric oxygen (HBO) to improve the region blood flow (rBF) of ischemic femoral head. " 07/01/1993 - "The clinical and dental records of 26 patients with the clinical diagnosis of postradiation osteonecrosis (PRON) managed with hyperbaric oxygen (HBO) were reviewed to determine the efficacy of HBO. " 10/01/2000 - "The study aimed at MRI evaluation of aseptic osteonecrosis (AON) in children over the course of hyperbaric oxygen (HBO) therapy. "
4.	Alendronate (Alendronate Sodium)FDA LinkGeneric 09/01/2008 - "Extracorporeal shockwave therapy (ESWT) and alendronate are reported effective in early osteonecrosis of the femoral head (ONFH). " 01/01/2015 - "Comment on "Efficacy of Alendronate for Preventing Collapse of Femoral Head in Adult Patients with Nontraumatic Osteonecrosis"." 01/01/2014 - "The purpose of the current review was to determine the efficacy of alendronate for preventing collapse of femoral head in adult patients with nontraumatic avascular osteonecrosis of femoral head (ANFH). " 01/01/2014 - "Efficacy of alendronate for preventing collapse of femoral head in adult patients with nontraumatic osteonecrosis." 01/01/2014 - "The purpose of this study was to investigate the influence of diabetes and corticotherapy on the development of osteonecrosis of the jaws associated with sodium alendronate. "
5.	Adrenal Cortex Hormones (Corticosteroids)IBA 01/01/2008 - "Most patients had received corticosteroids, had femoral head involvement and had delayed onset of osteonecrosis. " 07/01/2014 - "Osteonecrosis following short-term, low-dose oral corticosteroids: a population-based study of 24 million patients." 10/01/2015 - "Osteonecrosis is a musculo-skeletal disease secondary to cellular death of bone component mainly induced by corticosteroids, alcohol use, or connective tissue disorders. " 09/01/2015 - "We performed a meta-analysis and systematic literature review to determine osteonecrosis occurrences in patients taking corticosteroids at varying mean and cumulative doses and treatment durations, and whether medical diagnoses affected osteonecrosis incidence. " 07/01/2015 - "Contralateral osteonecrosis of the femoral head newly developed after increasing the dose of corticosteroids."
6.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 04/01/2014 - "The results from the present study demonstrate that EPO exerts prominent protective effects against glucocorticoid-induced osteonecrosis of the femoral head in rats by inhibiting the apoptosis of osteoblasts and osteocytes and increasing the expression of VEGF." 01/01/2012 - "We evaluated the efficacy of vascular endothelial growth factor 165 (VEGF(165)) transgenic bone marrow mesenchymal stem cells (BMSCs) for the repair of early-stage osteonecrosis of the femoral head (ONFH) in mature mongrel dogs. " 10/01/2015 - "The purpose of this study was to evaluate the association between vascular endothelial growth factor (VEGF) polymorphisms and bisphosphonate-related osteonecrosis of the jaw (BRONJ) in the Korean population. " 05/01/2015 - "These findings provide a new insight into VEGF and c-Src mode of reaction in triggering destructive repair of osteonecrosis and further indicate that VEGF mediating vascular permeability and osteoclasts activity are Src-dependent. " 01/01/2015 - "VEGF, eNOS, and ABCB1 genetic polymorphisms may increase the risk of osteonecrosis of the femoral head."
7.	NitrogenIBA 08/01/2009 - "Improved liquid nitrogen freezing of the femoral head provides a simple and convenient method for establishing animal models of femoral head osteonecrosis." 08/01/2009 - "To establish an canine model of femoral head osteonecrosis using an improved liquid nitrogen freezing method. " 01/01/2015 - "The results show a proinflammatory effect of the nitrogen-containing effect on neutrophil granulocytes which might contribute to the development of osteonecrosis. " 12/01/2014 - "Biphosphonate-associated maxillary bone osteonecrosis (BPMO) is a complication related to nitrogen-containing biphosphonate therapy. " 03/19/2013 - "A canine model of femoral head osteonecrosis was induced by liquid nitrogen freezing. "
8.	pamidronate (APD)FDA LinkGeneric 01/01/2006 - "Discontinuation of pamidronate therapy has not helped reverse the presence of osteonecrosis, and surgical manipulation of the involved site appears to worsen the underlying bone pathology. " 06/01/2012 - "She was treated with pamidronate and subsequently zolodronic acid before developing spontaneous bisphosphonate related osteonecrosis (BRONJ) of the left maxilla in December 2008. " 05/01/2012 - "The absence of anabolic effects of pamidronate on alveolar osteoblasts and the induction of apoptosis in osteogenic cells could negatively affect bone balance at this site and contribute to osteonecrosis of the jaw." 10/01/2010 - "In a retrospective analysis, eight patients in the pamidronate 90 mg group developed osteonecrosis of the jaw compared with two patients in the 30 mg group. " 03/01/2007 - "However, avascular osteonecrosis in the jawbone has been recently reported in patients receiving pamidronate. "
9.	Lovastatin (Mevacor)FDA LinkGeneric 11/01/1997 - "It is concluded that the bipedal chicken is a useful animal model for studies of osteonecrosis and that lipid clearing agents, such as Lovastatin, may be helpful in preventing the development of steroid induced osteonecrosis." 01/01/2000 - "The results indicate that steroid induced adipogenesis in the marrow may contribute to osteonecrosis and that lovastatin may be helpful in preventing the development of steroid induced osteonecrosis." 12/01/2008 - "Lovastatin can prevent development of steroid-induced osteonecrosis in rabbits by inhibiting adipogenesis. " 12/01/2008 - "To investigate in vivo effects of lovastatin on inhibition of adipogenesis, an important mechanism of steroid-induced osteonecrosis, and on prevention of occurrence of steroid-induced osteonecrosis in rabbits. " 12/01/2008 - "Lovastatin inhibits adipogenesis and prevents osteonecrosis in steroid-treated rabbits."
10.	TantalumIBA 11/18/2015 - "To study a modified porous tantalum technique for the treatment of osteonecrosis of the femoral head. " 01/01/2014 - "This study evaluated the outcomes of using porous tantalum rods for the treatment of osteonecrosis of the femoral head (ONFH). " 11/18/2015 - "Modified porous tantalum rod technique for the treatment of femoral head osteonecrosis." 01/01/2015 - "Autologous bone marrow mesenchymal stem cells associated with tantalum rod implantation and vascularized iliac grafting for the treatment of end-stage osteonecrosis of the femoral head." 01/01/2014 - "When ONFH was in a large range (120°), the tantalum rod implantation inside the osteonecrosis area, shortening implant or fibula implant can reduce the collapse values of the femoral head, as assessed by other methods."

Therapies and Procedures

1.	Decompression 04/01/2015 - "Core decompression with bone impaction allografting is effective for the treatment of osteonecrosis of femoral head. " 01/01/2000 - "We conclude that core decompression provides an effective treatment for steroid-associated osteonecrosis other than in cases with SLE, as well as providing effective treatment for non-steroid-associated osteonecrosis in the early stages of the disease." 05/01/2008 - "Our study confirms core decompression is a safe and effective procedure for treating early stage femoral head osteonecrosis." 01/01/2014 - "The study aims to compare the clinical efficacy of core decompression (CD) and bone marrow mesenchymal stem cells (BMMSC) on the patients with osteonecrosis of the femoral head (ONFH). " 09/01/2012 - "Efficacy of core decompression as treatment for osteonecrosis of the hip: a systematic review."
2.	Arthroplasty 10/07/2015 - "Prospective, multicenter, randomized trials are needed to evaluate the efficacy of these regimens in altering the natural history of the disease.➤ Joint-preserving procedures are indicated in the treatment of precollapse disease, with several studies showing successful outcomes at mid-term and long-term follow-up.➤ Studies of total joint arthroplasty, once femoral head collapse is present, have described excellent outcomes at greater than ten years of follow-up, which is a major advance and has led to a paradigm shift in treating these patients.➤ The results of hemiresurfacing and total resurfacing arthroplasty have been suboptimal, and these procedures have restricted indications in patients with osteonecrosis of the femoral head. " 03/01/2013 - "To investigate the curative efficacy of osteonecrosis of the femoral head (ONFH) in a hip-preserving operative approach, by grafting a vascularized greater trochanter flap combined with a free iliac flap, in an attempt to seek an innovative approach for patients who suffered middle to late stage ONFH without total hip arthroplasty (THA) surgery. " 11/01/2006 - "Although the outcomes of patients who have total knee arthroplasty for the treatment of spontaneous osteonecrosis of the knee have historically been favorable, such outcomes have also shown particular improvement in the studies from more recent operative periods. " 11/01/2006 - "Total knee arthroplasty performed as treatment for either secondary osteonecrosis or spontaneous osteonecrosis and unicompartmental knee arthroplasty performed as treatment for spontaneous osteonecrosis were associated with improved outcomes in cohorts with more recent operative dates. " 01/01/2015 - "Management of osteonecrosis of the hip with resurfacing arthroplasty seems to be effective in strictly-selected patients."
3.	Transplants (Transplant) 03/01/1995 - "Reported here is a case of steroid-induced osteonecrosis of the lateral femoral condyle that, according to preliminary results, was treated successfully with a vascularized bone and periosteal graft." 01/01/1992 - "Post-transplant diabetic patients were older, and had a significantly greater incidence of avascular necrosis of bone. " 02/15/2013 - "The purpose of this study was to investigate the therapeutic efficacy of transpedicular intracorporeal bone graft (IBG) in osteonecrosis of vertebral body (ONV) for 5-years follow-up period. " 02/15/2013 - "A therapeutic efficacy of the transpedicular intracorporeal bone graft with short-segmental posterior instrumentation in osteonecrosis of vertebral body: a minimum 5-year follow-up study." 01/01/2014 - "In this limited series AFG/BMP-7 combination proved a safe and effective method for the treatment of femoral head osteonecrosis, leading to early consolidation of the AFG and preventing collapse in five of seven hips, while the operative time and post-operative rehabilitation period were much shorter compared with free vascularised fibular grafts."
4.	Osteotomy 11/01/2006 - "In young patients with osteonecrosis and extensively collapsed lesions of the femoral head, posterior femoral neck rotational osteotomy appears to be effective in delaying the progression of degeneration if an adequate area of living bone can be placed under the loaded lateral portion of the acetabulum. " 11/01/2006 - "The prospect for success in the efficacy of osteotomy for precollapse stage of femoral head osteonecrosis depends on the ability to predict reliably the stress changes derived from specific osteotomies. " 01/01/2001 - "The rate of success of transtrochanteric rotational osteotomy for osteonecrosis of the femoral head may be improved if patients are preselected using MRI. " 09/01/2015 - "This study examined the outcomes of applying transtrochanteric rotational osteotomy (TRO) for posttraumatic osteonecrosis of the femoral head (ON). " 02/01/2015 - "In a historical cohort, 16 skeletally mature patients (9 men and 7 women) with Kienbock disease, who were treated with radial shortening osteotomy between 2002 and 2012, were reviewed in our study. "
5.	Transplantation (Transplant Recipients) 04/01/2008 - "Transplantation of BMMNCs may be a beneficial treatment for bone repair in the condition of osteonecrosis." 01/01/2008 - "Although our experience is limited to one patient, autologous cultured osteoblast transplantation appears to be effective for treating the osteonecrosis of femoral head." 09/01/2009 - "[Study on evaluating sex determining region of the Y as an engrafting track of BMSCs transplantation for repairing osteonecrosis of the femoral head of rabbit]." 07/01/2013 - "A higher cumulative steroid dose, age over ten years at diagnosis, and treatment with transplantation significantly increased the risk of osteonecrosis. " 07/01/2013 - "Bone marrow-derived mesenchymal stem cells (BM-MSCs) transplantation is widely adopted for the curing of osteonecrosis of femoral head (ONFH) in recent years. "