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Essential Osteolysis

Subscribe to New Research on Essential Osteolysis

Syndromes of bone destruction where the cause is not obvious such as neoplasia, infection, or trauma. The destruction follows various patterns: massive (Gorham disease), multicentric (HAJDU-CHENEY SYNDROME), or carpal/tarsal.

Also Known As:

Osteolysis, Essential; Bone Disease, Disappearing; Essential Osteolyses; Idiopathic Multicentric Osteolyses; Idiopathic Multicentric Osteolysis; Massive Osteolyses; Massive Osteolysis; Multicentric Osteolyses, Idiopathic; Multicentric Osteolysis, Idiopathic; Osteolyses, Essential; Osteolyses, Idiopathic Multicentric; Osteolyses, Massive; Disappearing Bone Disease; Gorham Disease; Osteolysis, Idiopathic Multicentric; Osteolysis, Massive

Networked: 43 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Musculoskeletal Diseases: 179
- Bone Diseases: 3566
  - Bone Resorption: 12154
    - Osteolysis: 2556
      - Essential Osteolysis: 43
        Myeloid splenomegaly: 39
  - Developmental Bone Diseases: 198
    - Essential Osteolysis: 43
      - Myeloid splenomegaly: 39

Related Diseases

1.	Foreign-Body Granuloma (Granuloma, Foreign Body)
2.	Essential Osteolysis
3.	Osteolysis
4.	Chylothorax
5.	Aggressive Fibromatosis (Desmoid)

Experts

1.	Egawa, Hiroshi: 1 article (01/2014)
2.	Goto, Tomohiro: 1 article (01/2014)
3.	Sairyo, Koichi: 1 article (01/2014)
4.	Naoto, Suzue: 1 article (01/2014)
5.	Yukata, Kiminori: 1 article (01/2014)
6.	Nishisho, Toshihiko: 1 article (01/2014)
7.	Hamada, Daisuke: 1 article (01/2014)
8.	Tamaki, Yasuaki: 1 article (01/2014)
9.	Sebecić, Bozidar: 1 article (12/2013)
10.	Zgaljardić, Ivonne: 1 article (12/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Essential Osteolysis:

1.	Interferon-alpha (Interferon Alfa)FDA Link 03/01/2005 - "Remission induced by interferon alfa in a patient with massive osteolysis and extension of lymph-hemangiomatosis: a severe case of Gorham-Stout syndrome." 03/01/2005 - "The authors report on a patient with multiple massive osteolyses and extensive lymph-hemangiomatosis whose lesions were reduced by interferon alfa therapy. "
2.	Polyethylene (Polythene)IBA 09/01/2012 - "Three hips in the patient group had massive osteolysis with polyethylene wear requiring revision surgery. " 03/01/2007 - "No femoral component was revised; however, five cups were revised because of breakage of the polyethylene or massive osteolysis. " 10/01/2005 - "In conclusion, the difference in the morphology of Hylamer polyethylene wear particles in comparison with PCA might have caused a more intensive biological response, early and massive osteolysis, and therefore, early loosening." 01/01/1997 - "Massive osteolysis induced by high molecular weight polyethylene wear debris." 12/01/1995 - "An early diagnosis of implant failure under arthroscopic control was made, which easily allowed revision of the metal-backed patellar button before the development of metallosis and massive osteolysis caused by the marked wear of polyethylene. "
3.	ultra-high molecular weight polyethylene (UHMWPE)IBA 09/01/1990 - "The results of this study demonstrate that UHMWPE wear products alone can cause massive osteolysis by triggering foreign-body granuloma formation at the bone-cement interface; the bone cement may remain fixed in areas beyond the osteolytic transformation."
4.	CobaltIBA 01/01/2000 - "A 14-year-old boy with massive osteolysis of the right scapula was treated by irradiation with a total dose of 58 Gy, using cobalt 60 (2 Gy per fraction) in 1983 and 1984. " 10/01/1999 - "The following case of massive osteolysis associated with large amounts of cobalt-chrome wear debris shows adhesive and abrasive wear mechanisms, as well as wear caused by third-body cobalt-chrome debris and impingement of the femoral component against the rim of the acetabular cup, which led to failure of a metal-on-metal total hip arthroplasty."
5.	Matrix Metalloproteinase 2 (Gelatinase A)IBA 09/01/2007 - "Sequence analysis of the matrix metalloproteinase 2 gene shows sporadic idiopathic multicentric osteolysis with nephropathy is not allelic to nodulosis-arthropathy-osteolysis syndrome. " 09/01/2007 - "We questioned whether sporadic idiopathic multicentric osteolysis with nephropathy is allelic with nodulosis-arthropathy osteolysis syndrome and undertook sequence analysis of the matrix metalloproteinase 2 gene in three unrelated affected boys. "
6.	Conditioned Culture MediaIBA 01/01/2004 - "Furthermore, to investigate the mechanism of osteolysis, we cultured tissue from a patient with massive osteolysis and examined the effects of the conditioned medium on osteoblasts in vitro. "
7.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 09/01/1998 - "In addition, when massive osteolysis was observed, the level of GM-CSF tended to decrease to that of the control group."
8.	Dental Implants (Dental Implant)IBA 02/01/2010 - "The management of a previously reported case of massive osteolysis of the mandible with intravenous bisphosphonate, vascularized free bone graft, and dental implants is reported. "
9.	Interleukin-6 (Interleukin 6)IBA 05/01/1996 - "Interleukin-6: a potential mediator of the massive osteolysis in patients with Gorham-Stout disease."
10.	HormonesIBA 09/01/1998 - "Since the main biological effect of calcitonin is to inhibit osteoclastic bone resorption, there is a possibility that massive osteolysis in our case could have been related to the lack of this hormone. "

Therapies and Procedures

1.	Arthroplasty 01/01/2014 - "We present a rare case of massive osteolysis with extreme femoral expansion that developed after cemented revision total hip arthroplasty. " 11/01/2013 - "Catastrophic failure due to massive osteolysis of both acetabular and femoral components in a metal-on-metal hip arthroplasty: a demonstrative case report." 01/01/2011 - "As the indications for total hip arthroplasty increase, the prevalence of extensive proximal femoral bone loss will increase as a consequence of massive osteolysis, stress shielding and multiple revisions. " 02/01/2001 - "We did not observe any case of massive osteolysis of the tibial metaphysis as described in the literature for non-cemented knee arthroplasties. " 04/01/1998 - "Massive osteolysis after ceramic on ceramic total hip arthroplasty."
2.	Radiotherapy 10/01/2012 - "Gorham disease of mandible treated with post-operative radiotherapy." 06/01/2008 - "We describe serial imaging findings, the treatment course, and radiotherapy response in a patient with pathologically confirmed Gorham disease involving the right mandible. " 06/01/2008 - "Gorham disease of the mandible: radiographic findings and radiotherapy response." 06/01/1985 - "Massive osteolysis in the hand and response to radiotherapy." 05/01/1986 - "Disappearing bone disease: massive osteolysis of the ribs treated with radiotherapy. "
3.	Transplants (Transplant) 04/01/2005 - "We present a case of massive osteolysis of the entire mandible, which was reconstructed with a free vascularised fibular graft and bilateral prosthetic replacements of the temporomandibular (TMJ) joints. " 02/01/2010 - "The management of a previously reported case of massive osteolysis of the mandible with intravenous bisphosphonate, vascularized free bone graft, and dental implants is reported. "
4.	Pleurodesis 08/01/1976 - "Massive osteolysis complicated by chylothorax successfully treated by pleurodesis." 12/01/1995 - " second case concerns a 17-year-old man who was known to have a massive osteolysis of the pelvis ring and who had used a wheel-chair from the age of 8. While hospitalized for a severe infection of the testicles and scrotum, he developped a recurrent chylothorax that required surgical pleurodesis. "
5.	Knee Prosthesis 01/01/1998 - "The lesion was associated with massive osteolysis around the femoral component of the total knee prosthesis." 08/01/1993 - "A case of massive osteolysis after knee prosthesis polyethylene failure."