Osteochondritis Dissecans

A type of osteochondritis in which articular cartilage and associated bone becomes partially or totally detached to form joint loose bodies. Affects mainly the knee, ankle, and elbow joints.

Also Known As:

Networked: 193 relevant articles (6 outcomes, 18 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Osteonecrosis (Kienbock's Disease)
3.	Osteoarthritis
4.	Wounds and Injuries (Trauma)
5.	Edema

Experts

1.	Bugbee, William D: 3 articles (10/2015 - 01/2002)
2.	Wall, Eric J: 3 articles (09/2014 - 07/2007)
3.	Cole, Brian J: 3 articles (03/2013 - 11/2009)
4.	Minami, Akio: 3 articles (12/2010 - 12/2007)
5.	Ochi, Mitsuo: 3 articles (02/2009 - 03/2004)
6.	Uchio, Yuji: 3 articles (02/2009 - 03/2004)
7.	Takahara, Masatoshi: 2 articles (09/2014 - 07/2002)
8.	Harada, Mikio: 2 articles (09/2014 - 07/2002)
9.	Berruto, Massimo: 2 articles (07/2014 - 10/2012)
10.	Ganley, Theodore J: 2 articles (04/2014 - 07/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Osteochondritis Dissecans:

1.	Hyaluronic Acid (Hyaluronan)IBA 07/01/2006 - "To determine the effect of oral hyaluronan gel on joint effusion following arthroscopic surgery for osteochondritis dissecans (OCD) of the tarsocrural joint of yearling Thoroughbreds. " 12/01/2008 - "Treatment of osteochondritis dissecans of the ankle with hyaluronic acid injections: a prospective study." 12/01/2008 - "No studies have evaluated the efficacy of hyaluronic acid (HA) in reducing pain caused by osteochondritis dissecans (OCD) of the ankle. "
2.	Durapatite (Hydroxylapatite)IBA 07/01/2014 - "the aim of the present study was to evaluate the clinical outcome of the treatment of osteochondritis dissecans (OCD) of the knee with a type-I collagen-hydroxyapatite nanostructural biomimetic osteochondral scaffold. " 05/01/2015 - "Arthroscopic fragment fixation using hydroxyapatite/poly-L-lactate Acid thread pins for treating elbow osteochondritis dissecans."
3.	tranilast (N 5')IBA 06/01/2003 - "Indications for operation were osteochondritis dissecans (OD) (n=13), limited arthritis (n=20), traumatic lesions (n=5) and retropatellar lesions (n=7). " 02/01/2005 - "Included in the study were 43 patients with ankle joint pain resulting from osteochondritis dissecans stage III-IV (n = 22), post-traumatic cartilage defects (n = 16), and focal osteoarthritis (n = 5). "
4.	Collagen Type I (Type I Collagen)IBA 07/01/2014 - "the aim of the present study was to evaluate the clinical outcome of the treatment of osteochondritis dissecans (OCD) of the knee with a type-I collagen-hydroxyapatite nanostructural biomimetic osteochondral scaffold. "
5.	Uric Acid (Urate)IBA 01/01/2014 - "The patients' BMI was 47.4, and he was also mis-diagnosed with osteochondritis dissecans and underwent medical treatment for JIA, assorted imaging studies, and multiple surgical procedures before the key history of increased pain with red meat ingestion, noticed by the patient, and a subsequent elevated uric acid confirmed his ultimate diagnosis. "
6.	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 12/01/1975 - "The overloaded humeral heads of the six growing Labrador retrievers treated with somatotropin and thyrotropin hormone showed the most pronounced changes of the articular cartilage and subchondral home, resembling changes in the early stage of spontaneous osteochondritis dissecans. " 12/01/1975 - "An experimental study into the etiological factors in osteochondritis dissecans in the canine humeral head using overloading with and without somatotropin and thyrotropin hormone treatment and mechanical trauma."
7.	Growth Hormone (Somatotropin)IBA 12/01/1975 - "The overloaded humeral heads of the six growing Labrador retrievers treated with somatotropin and thyrotropin hormone showed the most pronounced changes of the articular cartilage and subchondral home, resembling changes in the early stage of spontaneous osteochondritis dissecans. " 12/01/1975 - "An experimental study into the etiological factors in osteochondritis dissecans in the canine humeral head using overloading with and without somatotropin and thyrotropin hormone treatment and mechanical trauma."
8.	HormonesIBA 12/01/1975 - "The overloaded humeral heads of the six growing Labrador retrievers treated with somatotropin and thyrotropin hormone showed the most pronounced changes of the articular cartilage and subchondral home, resembling changes in the early stage of spontaneous osteochondritis dissecans. " 12/01/1975 - "An experimental study into the etiological factors in osteochondritis dissecans in the canine humeral head using overloading with and without somatotropin and thyrotropin hormone treatment and mechanical trauma."
9.	atelocollagenIBA 12/01/2004 - "In this study, we reported on a patient with osteochondritis dissecans of the talar dome, successfully treated by transplantation of tissue-engineered cartilage made ex vivo using atelocollagen gel and low tibial osteotomy."
10.	N 30IBA 10/01/2014 - "The study aimed to investigate the prognosis of osteochondral affection (e.g., osteochondritis dissecans (OCD), cartilage lesions, fractures and bone edema in the elbows of high-performance gymnasts (n=30) compared to prognosis results with athletes not undergoing excessive stress on the upper extremity (n=29). "

Therapies and Procedures

1.	Transplantation (Transplant Recipients) 05/01/2006 - "Osteochondral autograft transplantation is a useful treatment for reattachment of the lesion as well as osteochondral resurfacing of elbow osteochondritis dissecans." 11/01/2012 - "The purpose of this study was to evaluate the clinical outcomes of osteochondral autograft transplantation (OAT) for juvenile osteochondritis dissecans (JOCD) lesions of the knee, especially time to return to sports. " 12/01/2015 - "Concomitant Osteochondral Autograft Transplantation and Fixation of Osteochondral Fragment for Treatment of a Massive Osteochondritis Dissecans: A Report of 8-Year Follow-up Results." 09/01/2014 - "The trochlear groove is the rarest location for osteochondritis dissecans (OCD) of the knee, with only about 50 previously reported cases, most of which were treated before the advent of magnetic resonance imaging (MRI) and modern techniques of cartilage fixation or osteochondral transplantation. " 11/01/2012 - "Osteochondral autograft transplantation for juvenile osteochondritis dissecans of the knee: a series of twelve cases."
2.	Osteotomy 08/01/1997 - "This study reports one surgeon's experience using valgus high tibial osteotomy in the treatment of osteochondritis dissecans of the medial femoral condyle in adult patients. " 06/01/1968 - "[Koenig's osteochondritis dissecans of the hip treated surgically by varisation osteotomy (radiologic study of results of 3 cases)]." 08/01/2015 - "Medial Malleolar Osteotomy and Osteochondral Autograft Transfer for Osteochondritis Dissecans of the Distal Tibial Plafond." 06/01/2015 - "[Osteochondritis Dissecans of the Talus with Hindfoot Malalignment--Autologous Matrix-Induced Chondrogenesis with Lateral Calcaneal Distraction Osteotomy in an Internationally Successful Young Female Ski Racer]." 09/01/2012 - "A total of 32 patients who had cartilage lesions due to osteochondritis dissecans in the medial aspect of the talus underwent mosaicplasty after medial malleolar osteotomy. "
3.	Debridement 11/01/2010 - "The purpose of our study is to show that arthroscopic debridement is an appropriate intervention for midterm to long-term subjective symptom relief of osteochondritis dissecans (OCD) of the elbow. " 01/01/2014 - "Loose bodies are often a result of osteochondritis dissecans (OCD) of the capitellum, and arthroscopy in this case is useful for performing debridement, thereby eliminating the need for a more extensive open procedure associated with complications. " 02/15/2012 - "Osteochondritis dissecans of the elbow: excellent results in teenage athletes treated by arthroscopic debridement and microfracture." 08/01/2011 - "Arthroscopic debridement of the capitellum can provide excellent short-term results for the treatment of osteochondritis dissecans. " 08/01/2011 - "Although arthroscopic debridement of the humeral capitellum is an accepted procedure for osteochondritis dissecans, some patients develop radial head enlargement or osteoarthritic lesions after the procedure. "
4.	Transplants (Transplant) 07/01/2004 - "Treatment of chondral lesions in advanced osteochondritis dissecans: a comparative study of the efficacy of chondrocytes, mesenchymal stem cells, periosteal graft, and mosaicplasty (osteochondral autograft) in animal models." 01/01/1991 - "This study presents the results of twelve patients, treated by an autologous bone and cartilage transplant for an advanced stage (stage IV and V referring to Rodegerdts and Gleissner, 14) of osteochondritis dissecans of the knee. " 09/01/2014 - "Autologous osteochondral plug grafts have been used for capitellar osteochondritis dissecans (OCD), and good clinical results have been described. " 09/01/2014 - "Outcomes of an open autologous osteochondral plug graft for capitellar osteochondritis dissecans: time to return to sports." 11/01/2012 - "In case of osteochondritis dissecans (n = 13) an autologous bone graft was performed simultaneously. "
5.	Homologous Transplantation (Allograft) 04/01/2013 - "Can fresh osteochondral allografts restore function in juveniles with osteochondritis dissecans of the knee?" 03/01/2010 - "The use of a fresh osteochondral allograft for treatment of a lesion of the femoral condyle is relatively new, and we report its use in a unique situation involving identical twins who both presented with osteochondritis dissecans of the same anatomic location within 2 years of each other. " 02/01/2010 - "Case report: Fresh-stored osteochondral allograft for treatment of osteochondritis dissecans the femoral head." 06/01/2007 - "All were osteochondritis dissecans type 3 or 4. The mean allograft size was 7.5 cm(2). " 06/01/2007 - "As part of our comprehensive treatment program, fresh osteochondral allografts have been used in the surgical management of osteochondritis dissecans of the femoral condyle. "