Heterotopic Ossification (Ectopic Ossification)

12/01/2006 - "We were unable to demonstrate a statistically significant reduction in the incidence of severe heterotopic ossification with the use of indometacin when compared with a placebo (p = 0.722). "
01/01/1994 - "Statistical analysis revealed that indomethacin was effective in decreasing the overall incidence of heterotopic ossification (p < 0.01). "
02/01/2023 - "Endoscopic Excision of Hip Heterotopic Ossification, Plus Indomethacin and Radiation, Is Effective in Treating and Preventing Recurrence."
01/01/1992 - "Irradiation and indomethacin were effective in the prevention of severe heterotopic ossification. "
02/01/2017 - "This study evaluated the incidence of symptomatic radioulnar synostosis/heterotopic ossification after distal biceps tendon repair in patients receiving indomethacin prophylaxis. "

01/01/2008 - "The efficacy of NSAIDs in the avoidance of heterotopic ossification has been documented in controlled clinical trials, but the inherent risks (e.g. "
03/01/2016 - "The purpose of this systematic review was to investigate the efficacy of nonsteroidal anti-inflammatory drug (NSAID) prophylaxis for preventing heterotopic ossification (HO) in the setting of hip arthroscopy. "
01/01/2022 - "The majority of the cases were either Brooker grade I or II. Of the six studies investigating the effect of NSAID prophylaxis, five reported a significantly lower incidence of heterotopic ossification associated with its use. "
10/01/2021 - "We evaluate the incidence of heterotopic ossification (HO) development with nonsteroidal anti-inflammatory drug (NSAID) prophylaxis in patients after open and arthroscopic hip preservation surgery. "
10/01/2021 - "Incidence of Heterotopic Ossification with NSAID Prophylaxis Is Low After Open and Arthroscopic Hip Preservation Surgery."

04/01/2013 - "In this study, we investigated whether etoricoxib, a selective cyclo-oxygenase-2 (COX-2) inhibitor that produces fewer gastrointestinal side effects, is an effective alternative for the prevention of heterotopic ossification. "
04/01/2013 - "No heterotopic ossification was found in 62 % of the patients that took etoricoxib; 31 % of the patients had Brooker grade 1 and 7 % Brooker grade 2 ossification. "
08/01/2013 - "Response to comment on Brunnekreef et al.: Is etoricoxib effective in preventing heterotopic ossification after primary total hip arthroplasty?"
08/01/2013 - "Comment on Brunnekreef et al.: Is etoricoxib effective in preventing heterotopic ossification after primary total hip arthroplasty?"
04/01/2013 - "Etoricoxib seems effective in preventing heterotopic ossification after total hip arthroplasty. "

03/05/2018 - "The use of naproxen was associated with a significant reduction in the occurrence of heterotopic ossification at 1.5-, 3-, 6-, and 12-month follow-ups (P < 0.05). "
03/05/2018 - "Efficacy of naproxen prophylaxis for the prevention of heterotopic ossification after hip surgery: a meta-analysis."
12/01/2020 - "The observed rate of postoperative heterotopic ossification after 2 weeks of naproxen prophylaxis in this study was equivalent to that observed after 3 weeks' prophylaxis in a previously published study. "
12/16/2015 - "Beckmann, MD, MS, et al.: "Effect of Naproxen Prophylaxis on Heterotopic Ossification Following Hip Arthroscopy: A Double-Blind Randomized Placebo-Controlled Trial"."
12/16/2015 - "Effect of Naproxen Prophylaxis on Heterotopic Ossification Following Hip Arthroscopy: A Double-Blind Randomized Placebo-Controlled Trial."

06/01/2011 - "Prevention of heterotopic ossification and side effects with COX-2 inhibitors were significant in 2 studies. "
01/01/2023 - "We hypothesized that the low-dose prophylaxis protocol with selective cox-2 inhibitors decreases the risk of heterotopic ossification in open or arthroscopic hip preservation surgery in athletes. "
03/01/2016 - "Selective COX-2 Inhibitors Significantly Reduce the Occurrence of Heterotopic Ossification After Hip Arthroscopic Surgery."
06/01/2011 - "COX-2 inhibitors for the prevention of heterotopic ossification after THA."
01/01/2005 - "Sciatic nerve entrapment secondary to heterotopic ossification: imaging findings and potential effect of selective cox-2 inhibitors."

11/01/2015 - "The efficacy of celecoxib in preventing heterotopic ossification recurrence after open arthrolysis for post-traumatic elbow stiffness in adults."
01/01/2020 - "The effect of celecoxib in traumatic heterotopic ossification around temporomandibular joint in mice."
12/01/2019 - "Celecoxib cannot inhibit the progression of initiated traumatic heterotopic ossification."
11/01/2018 - "Celecoxib administration is associated with decreased incidence and severity of heterotopic ossification after hip resurfacing performed using the direct lateral approach in male patients. "
11/01/2018 - "Celecoxib was an independent predictor of decreased heterotopic ossification (odds ratio, 0.16; 95% confidence interval, 0.08-0.35). "

01/01/1999 - "No effective prophylaxis of heterotopic ossification with short-term ibuprofen."
02/01/1985 - "Heterotopic ossification appeared in one third of the patients in the ibuprofen group and in three fourths in the control group 12 months after surgery. "
02/01/1985 - "Effect of ibuprofen on heterotopic ossification after hip replacement."
06/01/2023 - "Efficacy of Ibuprofen after Total Hip Arthroplasty to Prevent Heterotopic Ossification: Systematic Review and Meta-Analysis."
12/01/2005 - "A 10-year follow-up of a randomized trial on ibuprofen for prevention of heterotopic ossification after hip arthroplasty."

01/01/1998 - "Prevention of periarticular heterotopic ossification after endoprosthetic hip joint replacement by means of diclofenac."
01/01/1992 - "We recommend Diclofenac prophylaxis against heterotopic ossification after hip operations in view of the serious clinical effects of this complication and its quoted incidence of 15% to 80%."
01/01/1992 - "In a double-blind prospective randomised study we examined the effects of Diclofenac on heterotopic ossification after hip arthroplasty. "
03/01/2022 - "Diclofenac for prophylaxis of heterotopic ossification after hip arthroplasty: a systematic review."
02/01/2004 - "In a monocentric, randomized, placebo-controlled double-blind study, we investigated the efficacy of two doses of diclofenac-cholestyramine for the prevention of heterotopic ossification (HO). "

01/01/2009 - "The clinical relevance of this study is that meloxicam and parecoxib may be helpful in reducing heterotopic ossification in humans."
12/01/2002 - "Prophylaxis of heterotopic ossification after total hip arthroplasty: a prospective randomized study comparing indomethacin and meloxicam."
06/01/2004 - "We were not able to show any difference between Indomethacin and Meloxicam in preventing heterotopic ossification after primary hip arthroplasty. "
04/01/2003 - "Indomethacin versus meloxicam for prevention of heterotopic ossification after total hip arthroplasty."
01/01/2009 - "The purpose of this study was to present the effectiveness of 2 cyclooxygenase-2 inhibitors, meloxicam and parecoxib, in the prevention of heterotopic ossification. "

10/15/2018 - "There was 1 case of heterotopic ossification in each group; 1 case of incision infection in group A and 1 case of incision superficial infection in group B, and were cured after 2 weeks of intravenous antibiotics administration. "
10/01/2019 - "Complications observed included one patient with a superficial wound infection which resolved with a course of oral antibiotics and one patient with radiographic evidence of heterotopic ossification which was conservatively managed. "
07/01/2019 - "Four (8.7%) complications were minor (Grades I or II): one Brooker Grade III heterotopic ossification requiring no treatment, one superior pubic ramus nonunion requiring no treatment and two superficial wound infections requiring antibiotics. "
08/01/2018 - "Another patient required operative removal of heterotopic ossification located around the tendon fixation site, which was the result of a superficial infection treated with antibiotics 2 weeks post-operatively. "
10/01/2013 - "Heterotopic ossification occurred in 6 hips, and infection, which resolved with antibiotics, occurred in 1 patient. "

12/01/1986 - "It was demonstrated that treatment with 2,000 rads of radiation that was initiated within four days after the total hip arthroplasty was highly effective in the prevention of heterotopic ossification and in the prevention of recurrence after resection of existing ossification. "
06/01/2012 - "In spite of the proven efficacy of pharmacological prophylaxis of heterotopic ossification following total hip arthroplasty, its routine use is still debated, and no data are available regarding the adherence to its administration in clinical practice. "
12/01/1986 - "In a previous prospective study, patients who were at high risk for heterotopic ossification after total hip arthroplasty were identified and an effective regimen for its prevention was established. "
12/01/1986 - "A prospective study was done to evaluate the efficacy of treatment with 1,000 rads of radiation in the prevention of heterotopic ossification after total hip arthroplasty in patients who are at high risk. "
03/01/2022 - "Low-dose Preoperative Unshielded Radiation Is Effective in Heterotopic Ossification Prophylaxis and Does Not Affect Porous Fixation in Total Hip Arthroplasty at 2 Years Minimum Follow-up: A Radiographic Study."

01/01/2009 - "Radiation therapy is proven to be effective in preventing heterotopic ossification. "
08/01/1997 - "Since 1987, two prospectively randomized trials were performed in patients with high-risk factors to develop heterotopic ossification: the first (HOP 1) to assess the prophylactic efficacy of postoperative low vs. medium dose radiotherapy, and the second (HOP 2) to assess the prophylactic efficacy of pre vs. postoperative radiotherapy. "
08/30/1994 - "In June 1992 a prospectively randomized trial was initiated to assess the comparative efficacy of pre- vs. postoperative prophylactic radiotherapy in patients with high risk to develop heterotopic ossification after hip surgery. "
05/01/2020 - "Herein, we report on the successful implementation of a quality improvement project in which changing the clinical workflow for postoperative radiation treatment to the hip to prevent heterotopic ossification improved the efficiency of patient care and decreased cost by eliminating redundant imaging through multidisciplinary participation. "
10/01/1996 - "The data about the high therapeutic efficacy of postoperative radiotherapy for prevention of heterotopic ossification were confirmed. "

07/01/2020 - "The present study documents the incidence of heterotopic ossification for a novel fourth-generation fixed-bearing 2-component prosthesis and reports a systematic review of the literature. "
07/01/2023 - "Furthermore, imaging assessments, including scapular notching, prosthesis aseptic loosening, and heterotopic ossification were evaluated on postoperative radiography at the final follow-up. "
02/01/2023 - "We aimed to investigate the medium-term radiological and clinical outcomes of patients who had received Alpha-D disk prosthesis after cervical disk surgery, in terms of incidence of heterotopic ossification (HO) and other complications. "
01/01/2022 - "Nevertheless, some patients will experience a mobility failure in their cervical prostheses over time because of heterotopic ossification. "
11/25/2021 - "Radiological data, including the prosthesis-endplate depth ratio, intervertebral height change, posterior heterotopic ossification (PHO) and angular parameters, were collected. "

01/01/2019 - "Although use of nonsteroidal antiinflammatory drugs and low-dose irradiation has demonstrated efficacy in preventing heterotopic ossification (HO) after THA and surgical treatment of acetabular fractures, these modalities have not been assessed after traumatic blast amputations where HO is a common complication that can arise in the residual limb. "
11/03/2023 - "While heterotopic ossification (HO) formation has been reported at rates of up to 90% following traumatic, combat-related amputations, previous studies included few patients with more proximal hip and pelvic level amputations. "
07/01/2016 - "The present study aimed to assess the incidence and risk factors for heterotopic ossification to further evaluate its role in partial foot amputation. "
11/03/2023 - "Heterotopic Ossification Formation in Military Beneficiaries Following Hip- and Pelvic-Level Amputations."
11/01/2022 - "There are no other published examples of using radiation alone for treatment of heterotopic ossification formation after transfemoral amputation without surgical revision of the bone formation. "

01/01/2022 - "Upon presentation with heterotopic ossification, neurological improvement achieved through potential restorative therapies might not translate into clinically meaningful functional improvement. "
01/01/2022 - "Treatment of Temporomandibular Joint Heterotopic Ossification: A Novel Protocol With Multimodal Therapy Based on Literature Review and Presentation of a Unique Case Report."
11/03/2021 - "Engineered osteoclasts as living treatment materials for heterotopic ossification therapy."
10/26/2021 - "Macrophages in heterotopic ossification: from mechanisms to therapy."
01/01/2020 - "This case presents the utility of ultrasound examination in diagnostics, providing accurate therapy and follow-up of entrapment syndrome of the ulnar nerve, caused by heterotopic ossification. "