Osmium Tetroxide

(T-4)-Osmium oxide (OsO4). A highly toxic and volatile oxide of osmium used in industry as an oxidizing agent. It is also used as a histological fixative and stain and as a synovectomy agent in arthritic joints. Its vapor can cause eye, skin, and lung damage.

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Networked: 174 relevant articles (4 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bogdanov, L A: 1 article (01/2021)
2.	Kutikhin, A G: 1 article (01/2021)
3.	Mishinov, S V: 1 article (01/2021)
4.	Mukhamadiyarov, R A: 1 article (01/2021)
5.	Běhalová, Hana: 1 article (04/2020)
6.	Dordevic, Dani: 1 article (04/2020)
7.	Kalčáková, Ludmila: 1 article (04/2020)
8.	Pospiech, Matej: 1 article (04/2020)
9.	Tremlová, Bohuslava: 1 article (04/2020)
10.	Iakovou, Ioannis: 1 article (04/2020)

Related Diseases

1.	Synovitis 07/01/1976 - "When an immune synovitis was induced in both knees of 16 rabbits, the osmic acid treated joint demonstrated a significantly greater synovitis and progressive aberrations compared to the untreated knee." 01/01/1986 - "We describe the successful rehabilitation and return to sport participation of a young boy, once bedridden by ankle synovitis, by the use of intraarticular osmic acid. " 01/01/1979 - "Use of osmic acid in the topical treatment of exudative synovitis of the knee joint." 01/01/1978 - "Osmic acid can still be recommended as a simple remedy in the treatment of knee joint synovitis, in both adults and children." 01/01/1977 - "Osmic acid in rheumatoid synovitis. "
2.	Knee Osteoarthritis 02/01/1996 - "The objective of this retrospective study was to compare the efficacy of osmic acid or radiation synovectomy with that of joint lavage for the treatment of knee osteoarthritis with effusions. "
3.	Malaria 10/01/1986 - "With the osmium tetroxide-zinc iodide impregnation technique the visualization of the internal organization of the exoerythrocytic form of the rodent malaria parasite Plasmodium berghei was improved. "
4.	Hypoxia (Hypoxemia) 09/01/1969 - "With s-Collidine-buffered osmium tetroxide and the glutaraldehyde-dichromate technique a marked decrease in density without an appreciable reduction in number of granules was noted after reserpine treatment, while in hypoxia-treated hamsters the density and population of the granules were not different from those of the controls. " 09/01/1969 - "The carotid bodies from control, reserpine-treated, and hypoxia-treated hamsters were fixed with phosphate-buffered glutaraldehyde and osmium tetroxide, s-Collidine-buffered osmium tetroxide, or phosphate-buffered glutaraldehyde followed by potassium dichromate incubation. "
5.	Dehydration (Water Stress) 01/01/1983 - "Samples were post-fixed in 2 per cent buffered osmium tetroxide for 24 h prior to dehydration in ascending grades of acetones. " 12/01/1981 - "Organization of actin in the leading edge of cultured cells: influence of osmium tetroxide and dehydration on the ultrastructure of actin meshworks." 06/01/2006 - "To clarify how the lamellar body was formed during the conventional preparation steps, lung tissues of mice were treated with different fixation procedures, such as immersion-fixation with osmium tetroxide or perfusion-fixation with glutaraldehyde followed by osmium tetroxide, in combination with alcohol dehydration or QF-FD-OsV. " 10/30/2005 - "After being fixed by 2.5% glutardialdehyde and 1% osmic acid, alcohol dehydration, gilded by ion spatter, the specimens were observed under SEM by STEREOSCAN-100. " 11/01/1996 - "The processing of yeast cells for scanning electron microscopy by conventional sequential fixation with glutaraldehyde and osmium tetroxide and subsequent dehydration and critical point-drying caused pronounced deformation and visible shrinkage in all basidiomycetous and ascomycetous yeast strains studied. "

Related Drugs and Biologics

1.	Glutaral (Glutaraldehyde)
2.	gamma-collidine (collidine)
3.	Reserpine (Serpasil)
4.	zinc iodide
5.	Yttrium
6.	uranyl acetate
7.	Formaldehyde (Formol)
8.	Fixatives (Pickling Agents)
9.	Ruthenium Red
10.	Glycerol (Glycerine)

Related Therapies and Procedures

1.	Synovectomy
2.	Intra-Articular Injections
3.	Therapeutics
4.	Injections
5.	Aftercare (After-Treatment)