Orthomyxoviridae Infections

Virus diseases caused by the ORTHOMYXOVIRIDAE.

Also Known As:

Infections, Orthomyxoviridae; Infections, Orthomyxovirus; Swine Influenza; Infection, Orthomyxoviridae; Infection, Orthomyxovirus; Influenza, Swine; Orthomyxoviridae Infection; Orthomyxovirus Infection; Orthomyxovirus Infections

Networked: 643 relevant articles (54 outcomes, 84 trials/studies)

Relationship Network

Disease Context: Research Results

Infections: 526564
- Virus Diseases: 41777
  - RNA Virus Infections: 303
    - Orthomyxoviridae Infections: 643
      - Human Influenza: 36431
      - Influenza in Birds: 4001

Related Diseases

1.	Infections
2.	Human Influenza (Influenza)
3.	Virus Diseases (Viral Diseases)
4.	Acute Lung Injury
5.	Bites and Stings (Sting)

Experts

1.	Vincent, Amy L: 27 articles (01/2021 - 11/2006)
2.	Lager, Kelly M: 20 articles (01/2020 - 07/2003)
3.	Webby, Richard J: 16 articles (11/2021 - 07/2003)
4.	Van Reeth, Kristien: 15 articles (06/2022 - 01/2006)
5.	Janke, Bruce H: 15 articles (10/2012 - 07/2003)
6.	Ma, Wenjun: 12 articles (01/2021 - 12/2006)
7.	Qiao, Chuanling: 11 articles (07/2022 - 02/2008)
8.	Pomorska-Mól, Małgorzata: 11 articles (12/2019 - 07/2011)
9.	Richt, Jürgen A: 11 articles (12/2017 - 07/2003)
10.	Renukaradhya, Gourapura J: 10 articles (01/2021 - 11/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Orthomyxoviridae Infections:

1.	VaccinesIBA 08/01/2018 - "Protective efficacy of a high-growth reassortant H1N1 influenza virus vaccine against the European Avian-like H1N1 swine influenza virus in mice and pigs." 09/28/2011 - "Efficacy of a pandemic (H1N1) 2009 virus vaccine in pigs against the pandemic influenza virus is superior to commercially available swine influenza vaccines." 11/03/2022 - "Nanoparticle-Based Bivalent Swine Influenza Virus Vaccine Induces Enhanced Immunity and Effective Protection against Drifted H1N1 and H3N2 Viruses in Mice." 01/01/2017 - "In the present study, we evaluated the efficacy of ∼200nm polyanhydride nanoparticles encapsulating inactivated swine influenza A virus (SwIAV) as a vaccine to induce protective immunity against a heterologous IAV challenge in pigs. " 11/03/2022 - "These results suggest that this novel bivalent nanoparticle swine influenza vaccine can be used as an efficacious vaccine candidate to induce robust immunity and provide broad protection against drifted subtypes in mice. "
2.	Hemagglutinins (Hemagglutinin)IBA 09/01/2013 - "An eight-segment swine influenza virus harboring H1 and H3 hemagglutinins is attenuated and protective against H1N1 and H3N2 subtypes in pigs." 01/01/2023 - "An Orf-Virus (ORFV)-Based Vector Expressing a Consensus H1 Hemagglutinin Provides Protection against Diverse Swine Influenza Viruses." 04/01/2014 - "Immunogenicity and efficacy of a recombinant adenovirus expressing hemagglutinin from the H5N1 subtype of swine influenza virus in mice." 06/01/2011 - "This study utilizes an expansive data set of hemagglutinin (HA1) sequences (n = 1516) from swine influenza viruses collected in North America during the period 2003-2010. " 10/01/2010 - "In this study, a multiplex RT-PCR method was developed for simultaneous identification of hemagglutinin (HA) genes derived from the three lineages of swine influenza viruses. "
3.	Proteins (Proteins, Gene)FDA Link 01/01/2022 - "IMPORTANCE Swine influenza A viruses (swIAVs) with a truncated NS1del126 protein were strongly attenuated in previous laboratory-based safety studies and therefore approved for use as LAIVs for swine in the United States. " 01/01/2022 - "In this study, a quantitative proteomics approach based on an iTRAQ combined with LC-MS/MS was used to profile proteins expressed in A549 cells infected with H1N1 swine influenza virus (SIV). " 06/01/2017 - "Therefore, our study demonstrates that PA-X protein acts as a negative virulence regulator for classical H1N1 swine influenza virus and decreases virulence by inhibiting viral replication and polymerase activity, deepening our understanding of the pathogenesis of swine influenza virus." 01/01/2016 - "Hence, studies on swine influenza viruses (SIV) and identification of swine influenza NS1-interacting host proteins is of great interest. " 01/01/2016 - "In this study, we explored the role of PB1-F2 protein of triple-reassortant (TR) H3N2 swine influenza virus (SIV) in pigs and turkeys. "
4.	SAIDS VaccinesIBA 11/03/2022 - "In this study, we evaluated the protective efficacy of a recombinant, baculovirus-insect cell system-expressed bivalent nanoparticle SIV vaccine in mice challenged with drifted swine influenza H1N1 and H3N2 viruses. " 08/15/2006 - "This study investigated the efficacy of a bivalent swine influenza virus (SIV) vaccine in piglets challenged with a heterologous H1N1 SIV isolate. " 05/11/2015 - "The human A/Port Chalmers/1/73 (H3N2) influenza virus strain, the supposed ancestor of European H3N2 swine influenza viruses (SIVs), was used in most commercial SIV vaccines in Europe until recently. " 08/15/2011 - "Humoral and cellular immune responses to inactivated swine influenza virus (SIV) vaccine were evaluated and compared. " 11/18/2009 - "The objective of this study was to assess the effect of concurrent infection with porcine reproductive and respiratory syndrome virus (PRRSV) on the efficacy of an inactivated swine influenza virus (SIV) vaccine. "
5.	DNA (Deoxyribonucleic Acid)IBA 11/01/2011 - "DNA vaccination elicits protective immune responses against pandemic and classic swine influenza viruses in pigs." 04/01/2010 - "Prime-boost immunization with HA/C3d DNA followed by a recombinant pseudorabies virus boost enhanced protective immunity against H3N2 swine influenza virus in mice." 05/22/2000 - "DNA vaccination against influenza viruses: a review with emphasis on equine and swine influenza." 12/01/2016 - "The results suggest that polyvalent DNA influenza vaccination may provide a strong tool for broad protection against swine influenza strains threatening animal as well as public health. " 10/01/2013 - "The assay successfully detected CAEV proviral DNA in total DNA extracts originating from cell culture, whole blood samples and isolated PBMCs, with a lower detection limit of 10(2) copies and a linear dynamic range of 10(5) to 10(10) copies/ml. There was no cross-reaction with other animal viruses (e.g., goat pox virus, bovine leukemia virus, bovine mucosal disease virus, swine influenza virus and Nipah virus). "
6.	Pancreatic Elastase (Elastase)IBA 02/01/2009 - "Reverse genetics-generated elastase-dependent swine influenza viruses are attenuated in pigs." 10/01/2009 - "Elastase-dependent live attenuated swine influenza A viruses are immunogenic and confer protection against swine influenza A virus infection in pigs." 04/12/2011 - "An elastase-dependent attenuated heterologous swine influenza virus protects against pandemic H1N1 2009 influenza challenge in swine." 10/08/2010 - "Immunogenicity and protective efficacy of an elastase-dependent live attenuated swine influenza virus vaccine administered intranasally in pigs." 12/23/2022 - "We previously developed an elastase-dependent bivalent live attenuated vaccine using two Canadian swine influenza A virus (swIAV) isolates, A/Swine/Alberta/SD0191/2016 (H1N2) [SD191] and A/Swine/Saskatchewan/SD0069/2015 (H3N2) [SD69], which provided protection against homologous strains. "
7.	AntibodiesIBA 09/01/2014 - "Live-attenuated influenza virus (LAIV) prime-boost vaccination previously conferred protection against heterologous H3N2 swine influenza challenge, including in piglets with maternally derived antibodies (MDA). " 07/01/2022 - "In this study, we used A/swine/Guangxi/18/2011 (GX/18) and A/swine/Guangdong/104/2013 (GD/104) as models to explore the molecular determinant for antigenic variation of Eurasian avian-like H1N1 (EA H1N1) swine influenza viruses (SIVs) and found that the GD/104 virus exhibited 32- to 64-fold lower antigenic cross-reactivity with antibodies against GX/18 virus. " 02/01/2018 - "The objective of this study was to investigate the association between environmental temperature and humidity and the presence of antibodies for two specific strains of swine influenza viruses: A/SW/ON/105-56/12/H3N2 (H3N2_D) and A/SW/ON/84/2012/H1N1 (H1N1_P). " 11/03/2016 - "Many studies report reliable evidence of antibodies to swine influenza viruses among persons occupationally exposed to pigs. " 11/01/2014 - "A cross-sectional serological study was conducted in Bhutan between October 2011 and February 2012 to determine the prevalence of antibodies to classical swine fever virus (CSFV), porcine reproductive and respiratory syndrome virus (PRRSV), porcine circovirus type 2 (PCV2), swine influenza virus (SIV) subtype H1N1 and Aujeszky's disease virus (ADV). "
8.	Inactivated VaccinesIBA 10/01/2012 - "Control of swine influenza A virus (IAV) in the United States is hindered because inactivated vaccines do not provide robust cross-protection against the multiple antigenic variants cocirculating in the field. " 12/01/2019 - "A swine influenza A pandemic 2009 H1N1 (pH1N1) virus was used in a pig challenge model to investigate the efficacy of whole inactivated vaccines homologous or heterologous to the challenge virus as well as a commercial vaccine. " 02/01/2001 - "The present results indicate that intranasal immunization of pigs with inactivated vaccines is effective to control swine influenza, and also provide a good model, as well as a mouse model, to evaluate an intranasal application of influenza vaccine for humans." 03/24/2010 - "The objective of this study was to evaluate the efficacy of inactivated vaccines prepared with North American swine influenza viruses as well as an experimental homologous A/H1N1 vaccine to prevent infection and disease from 2009 pandemic A/H1N1. " 01/01/2020 - "In a previous study in influenza-naïve pigs, heterologous prime-boost vaccination with monovalent, adjuvanted whole inactivated vaccines (WIV) based on the European swine influenza A virus (SwIAV) strain, A/swine/Gent/172/2008 (G08), followed by the US SwIAV strain, A/swine/Pennsylvania/A01076777/2010 (PA10), was shown to induce broadly cross-reactive hemagglutination inhibition (HI) antibodies against 12 out of 15 antigenically distinct H3N2 influenza strains. "
9.	Influenza Vaccines (Influenza Vaccine)FDA Link 01/01/2023 - "The goal of this study was to examine the immunogenicity and protective efficacy of diverse H1N1 influenza vaccine strategies including monovalent, bivalent, and heterologous prime-boost vaccination regimens, against a mismatched H1N2 swine influenza virus. " 06/01/2019 - "Influenza vaccine trials peaked during the 2009 H1N1 swine influenza outbreak. " 03/02/2021 - "Objective: To evaluate the cross-reaction of seasonal influenza vaccine immune serum against Eurasian avian-like H1N1 swine influenza virus. " 03/02/2021 - "[Cross-reaction of seasonal influenza vaccine immune serum against Eurasian Avian-like H1N1 swine influenza virus]." 06/19/2020 - "In 2009, a novel influenza vaccine was distributed worldwide to combat the H1N1 influenza "swine flu" pandemic. "
10.	DNA VaccinesIBA 06/27/2012 - "In this study, two forms of DNA vaccines were constructed, one was made by fusing M2e to consensus H3HA (MHa), which represents the majority of the HA sequences of H3N2 swine influenza viruses. " 08/01/2012 - "DNA-vaccine platform development against H1N1 subtype of swine influenza A viruses." 01/01/2010 - "Preparation and immunological effectiveness of a Swine influenza DNA vaccine encapsulated in PLGA microspheres." 11/03/2011 - "Preparation and immunological effectiveness of a swine influenza DNA vaccine encapsulated in chitosan nanoparticles." 01/01/2010 - "Optimal preparation conditions of DNA vaccine against swine influenza encapsulated in Poly (D,L)-lactic-co-glycolic acid (PLGA) microspheres were determined. "

Therapies and Procedures

1.	Intranasal Administration 01/15/2015 - "Importantly, intranasal administration of PAV provided protection against the antigenic variant MN08 and the heterologous NC10 swine influenza viruses as evidenced by significant reductions in lung virus load, gross lung lesions and significantly reduced shedding of challenge viruses in nasal secretions. "
2.	Therapeutics 01/01/2011 - "Analysis of the experience gained during the last pandemic of 'swine' influenza A (H1N1) sw1 is presented with reference to clinical studies and etiotropic therapy. " 04/01/1946 - "The effect of roentgen therapy on experimental virus pneumonia; on pneumonia produced in white mice by swine influenza virus." 03/01/2010 - "This article examines the swine influenza (H1N1) strain of recent origin, and compares the microbiology, epidemiology, clinical presentation, differential, clinical, and laboratory diagnosis, therapy, complications, and prognosis with previous recorded outbreaks of avian and human seasonal influenza pneumonias." 05/01/2019 - "The effect of a standard, single dose therapy with tulathromycin was investigated on the postvaccinal humoral and cellular immune response in pigs vaccinated against swine influenza. " 11/01/2009 - "During the "herald wave" of the pandemic bacterial pneumonia relatively rare with fatal swine influenza (H1N1) pneumonia: if chest films have no focal segmental/lobar infiltrates, antibiotic therapy is unnecessary."
3.	Critical Care (Surgical Intensive Care) 12/01/2010 - "The Swine Flu Triage (SwiFT) study: development and ongoing refinement of a triage tool to provide regular information to guide immediate policy and practice for the use of critical care services during the H1N1 swine influenza pandemic." 09/01/2009 - "Pandemic (H1N1) 2009 influenza ("swine flu") in Australian and New Zealand intensive care." 09/01/2015 - "Because of limited treatment options, high risk for secondary infection, and frequent need for intensive care of individuals with H1N1 pneumonia, environmental control, including vaccination of high-risk populations and public education are critical to control of swine influenza out breaks."
4.	Castration 12/01/2019 - "In the present study, we monitored a group of vaccinated and non-vaccinated piglets in a Danish sow herd that initiated piglet vaccination with ¼ dose of an inactivated swine influenza vaccine at the time of castration (day 3-4). "
5.	Extracorporeal Membrane Oxygenation 02/01/2017 - "Swine influenza A (H1N1) virus (SIV) infection requiring extracorporeal life support in an immunocompetent adult patient with indirect exposure to pigs, Italy, October 2016." 12/01/2016 - "Severe acute respiratory infection caused by swine influenza virus in a child necessitating extracorporeal membrane oxygenation (ECMO), the Netherlands, October 2016." 10/01/2010 - "Spontaneous delivery during veno-venous extracorporeal membrane oxygenation in swine influenza-related acute respiratory failure."