Onchocerciasis

01/01/2008 - "We have helped administer nearly 20% of the 530 million Mectizan (ivermectin) doses for onchocerciasis, which is now being controlled throughout most of Africa, and is progressing toward elimination in the Americas. "
04/01/2004 - "Through the extensive clinical testing protocols implemented in a variety of countries in Aftica, ivermectin has been proven to be a safe and highly effective treatment for onchocerciasis. "
05/01/1994 - "Ivermectin is highly effective against animal intestinal nematodes and is used in the treatment of onchocerciasis in humans. "
01/01/2021 - "Even though the Ethiopian government has set a goal to eliminate onchocerciasis through community-directed treatment with the ivermectin, which is proven effective in treating the disease, the magnitude of compliance with the treatment among adults aged ≥15 years in the Semen Bench District is still unacceptably low. "
02/07/2003 - "In the Americas, through support of the Onchocerciasis Elimination Program in the Americas (OEPA), a strategy of bi-annual ivermectin treatment of at least 85% of the eligible populations in all endemic communities is showing very good results and promises to be effective in eliminating onchocerciasis in the region.The"

04/13/2010 - "Therefore, further trials are warranted to assess the safety and efficacy of doxycycline-based interventions to treat onchocerciasis in individuals at risk of serious adverse reactions to standard treatments due to the co-occurrence of high intensities of L. "
08/27/2009 - "Doxycycline has been shown to be effective in the treatment of onchocerciasis and has the added advantages of killing adult Onchocerca volvulus but neither adult Loa loa nor their microfilariae. "
05/01/2006 - "Recent research using a chemotherapeutic approach that targets filarial Wolbachia symbionts in the treatment and control of onchocerciasis, however, suggests that 100 mg/d of doxycycline for 6 weeks might be effective in reducing the filarial load and preventing ocular symptoms."
12/01/2001 - "In the first trial on human onchocerciasis depletion of bacteria following treatment with doxycycline resulted in a complete and long-term block of embryogenesis. "
10/01/2023 - "Overall, the total economic cost of implementing the doxycycline test-and-treat strategy for onchocerciasis elimination in Massangam came to US$168,345. "

09/01/1980 - "A double-masked, controlled clinical trial was conducted in Guatemala to assess the safety and efficacy of diethylcarbamazine (DEC) lotion as compared to placebo lotion in the treatment of onchocerciasis. "
12/01/1987 - "Analyses are made of a pooled set of data from ten separate studies of diethylcarbamazine (DEC) conducted at the Onchocerciasis Chemotherapeutic Research Centre, Tamale, between 1978 and 1983. "
05/10/1952 - "A histological study of onchocerciasis treated with hetrazan."
01/01/2007 - "As part of a baseline data collection for assessing the impact of the African Programme for Onchocerciasis Control, to evaluate the diethylcarbamazine (DEC) patch test in determining the endemicity of onchocerciasis. "
01/01/2007 - "Evaluation of the diethylcarbamazine patch to evaluate onchocerciasis endemicity in Central Africa."

01/01/2018 - "In these areas, alternative treatment strategies should be explored, including biannual albendazole monotherapy for LF (1.4 million individuals) and 'test-and-treat' strategies (8.7 million individuals) for onchocerciasis. "
12/01/2016 - "Though MDA for onchocerciasis started in 1988, in 2014 albendazole had not yet been added for LF. "
10/01/1992 - "Albendazole in the treatment of onchocerciasis: double-blind clinical trial in Venezuela."
10/01/2008 - "The results of the present study indicate a relatively high effectiveness of MDA using a DEC/albendazole combination against Wuchereria bancrofti infection and, therefore, it may be a useful strategy to eliminate lymphatic filariasis in onchocerciasis-free areas."
11/01/2022 - "However, the "guideline review process" depended heavily on preliminary results from multicenter studies that were performed to compare the safety, tolerability, and acceptability of IDA versus DA (the two-drug regimen of DEC plus albendazole that was recommended for use for filariasis elimination in countries without co-endemic onchocerciasis or loiasis). "

11/01/1990 - "These antigens may be useful as targets for improved diagnostic tests for onchocerciasis based on parasite antigen detection."
06/30/2005 - "In the search for Onchocerca volvulus antigens possibly involved in protection against human onchocerciasis, partial amino acid sequence analysis of one of the O. "
09/01/1993 - "Thus, although this study has provided new information on parasite antigens in sera from onchocerciasis patients, additional work will be needed to achieve the goal of producing a sensitive and specific antigen diagnostic test for onchocerciasis."
09/01/1989 - "In order to assess the possible suppression of immune responses to non-specific antigens in patients with generalized onchocerciasis, a vaccination study was conducted among the population of eight Liberian villages. "
06/01/1986 - "A study on antigen recognition by onchocerciasis patients with different clinical forms of disease."

03/01/2023 - "Moxidectin, registered in 2018 for treatment of individuals ≥ 12 years old with onchocerciasis, is undergoing studies to extend the indication to 4-11-year-old children and obtain additional data to inform WHO and endemic countries' decisions on moxidectin inclusion in guidelines and policies. "
06/01/2014 - "Provided its results confirm those from this study, availability of moxidectin to control programmes could help them achieve onchocerciasis elimination objectives. "
07/01/2022 - "Moxidectin, a well-established drug in veterinary medicine, is now a Food and Drug Administration (FDA) approved medication for human onchocerciasis. "
01/01/2022 - "From a pharmacokinetic perspective, moxidectin is an attractive long-acting therapeutic option for the treatment of human onchocerciasis."
01/01/2022 - "Moxidectin was approved by the United States Food and Drug Administration in 2018 for the treatment of onchocerciasis in people at least 12 years of age. "

01/01/2016 - "The vaccines developed in this study have the potential of reducing the morbidity associated with onchocerciasis in humans."
05/27/2022 - "Collectively, this evidence suggests vaccine formulations for human onchocerciasis should aim to elicit similarly balanced Th1/Th2 immune responses."
05/27/2022 - "The identification and development of efficacious vaccines as complementary preventive tools to support ongoing elimination efforts are therefore an important objective of onchocerciasis research. "
01/01/2018 - "This review summarizes the progress made to advance the onchocerciasis vaccine from the research laboratory into the clinic."
01/01/2018 - "Needed, and needed now, in the fight to eliminate onchocerciasis are new tools, such as preventive and therapeutic vaccines. "

01/01/2011 - "Current research needs and control methods by which the public health community in endemic countries may respond to resistance, should it occur in their area, are discussed, along with the continuing importance of this anthelmintic as the mainstay in onchocerciasis control programs."
01/01/2009 - "Sampling strategies to detect anthelmintic resistance: the perspective of human onchocerciasis."
12/01/2006 - "This anthelmintic is the only drug approved for mass administration to control onchocerciasis caused by the nematode parasite, Onchocerca volvulus. "
01/25/2011 - "A better understanding of reproductive processes in parasitic nematodes may lead to development of new anthelmintics and control strategies for combating disabling and disfiguring neglected tropical diseases such as lymphatic filariasis and onchocerciasis. "
01/01/2010 - "The advent of mass drug administration programmes for the control of schistosomiasis, lymphatic filariasis, onchocerciasis and soil-transmitted helminthiases in humans increases the urgency to better understand and better monitor drug resistance, and to broaden the currently very narrow range of available anthelmintics. "

12/01/1985 - "Suramin in the treatment of onchocerciasis: the efficacy of low doses on the parasite in an area with vector control."
05/01/1998 - "Ten male patients with onchocerciasis received six weekly infusions of suramin according to the WHO-recommended regimen. "
05/01/1998 - "Clinical pharmacokinetics of suramin in patients with onchocerciasis."
06/13/1987 - "Suramin and eosinophil degranulation and vacuolation in onchocerciasis."
12/01/1985 - "In a village hyperendemic for onchocerciasis in Burkina Faso, where the vector had been controlled by the Onchocerciasis Control Programme since 1976, 65 patients were treated with doses of 37 to 71 mg/kg suramin in 1979. "

01/01/2022 - "The aims of this study were i) to characterize the population pharmacokinetic properties of emodepside, ii) to link its exposure to adverse events in healthy volunteers, and iii) to propose an optimized dosing regimen for a planned phase II study in onchocerciasis patients. "
01/01/2022 - "Emodepside has shown macrofilaricidal activity against a variety of nematodes and is currently under clinical development for the treatment of onchocerciasis. "
01/01/2022 - "Drug development for the treatment of onchocerciasis: Population pharmacokinetic and adverse events modeling of emodepside."
01/01/2021 - "Therefore, emodepside is considered to be among the most promising candidates for evaluation as an adulticide treatment against onchocerciasis. "
01/01/2021 - "Development of emodepside as a possible adulticidal treatment for human onchocerciasis-The fruit of a successful industrial-academic collaboration."

01/01/1990 - "The primary objective of the Wellcome Foundation/World Health Organisation Onchocerciasis Chemotherapy Project, which began in July 1982, was the discovery and development of a safe and effective macrofilaricide for the treatment of onchocerciasis in man. "
02/01/1985 - "The efficacy of the drug on single dosage and the mild adverse reactions produced, if confirmed in subsequent controlled studies, would greatly simplify the treatment of onchocerciasis and would reintroduce new concepts of the role of chemotherapy in the control of onchocerciasis."
01/01/1990 - "In the context of the future of the OCP and of the control of onchocerciasis elsewhere in the world, the need for improved chemotherapy is discussed. "
10/16/2020 - "This study has revealed that the Ndikinimeki Health District is hypo-endemic for onchocerciasis after about two decades of preventive chemotherapy. "
08/01/1993 - "The primate and rodent models developed in the present study will be useful for the study of the immunology and chemotherapy of onchocerciasis."

01/01/2016 - "In some regions in Africa, elimination of onchocerciasis may be possible with mass drug administration, although there is concern based on several factors that onchocerciasis cannot be eliminated solely through this approach. "
11/07/2023 - "The objective of this study was to assess the situation of onchocerciasis transmission in the Cascades region, nine years after the resumption of mass drug administration. "
11/14/2023 - "Awareness of and participation in mass drug administration programs used for onchocerciasis control in the Atwima Nwabiagya North District, Ghana."
07/01/2023 - "Enhancing onchocerciasis elimination program management: A biological approach to deciding when to begin Stop Mass Drug Administration activities."
07/01/2023 - "Correction: Onchocerciasis: Target product profiles of in vitro diagnostics to support onchocerciasis elimination mapping and mass drug administration stopping decisions."

01/01/2022 - "New Research Aims to Optimize Therapy Against Onchocerciasis."
04/01/2002 - "Indications of antiwolbachial therapy against onchocerciasis are discussed."
03/01/2002 - "In principle, onchocerciasis has reverted to the situation before occurrence of ocular complications in consequence of the ongoing control measures even though the insect destruction and mass therapy are sometimes incomplete. "
06/01/1999 - "Analysis of renal function in onchocerciasis patients before and after therapy."
01/01/1990 - "It is concluded, that "Ganna Ganna" could be a useful adjuvant in the therapy of onchocerciasis and that further evaluation of the drug seems promising."

12/01/2016 - "A new formulation that enables sufficient bioavailability following oral administration could render FLBZ an effective treatment for onchocerciasis and LF. "
12/01/2015 - "However, a new formulation that provided sufficient bioavailability following oral administration could render FLBZ an effective treatment for onchocerciasis and LF. "
10/01/1990 - "The influence of food on the pharmacokinetics of CGP 6140 (amocarzine) after oral administration of a 1200 mg single dose to patients with onchocerciasis."
10/01/1990 - "Pharmacokinetics of CGP 6140 (amocarzine) after oral administration of single 100-1600 mg doses to patients with onchocerciasis."
06/01/1994 - "Lymph node and skin biopsies from Liberian patients with generalized and localized (sowda) onchocerciasis were studied 12-68 hours after oral administration of ivermectin at a single dose of 150 micrograms/kg body weight. "

08/01/1990 - "Changes in antibody profile after treatment of human onchocerciasis."
01/01/1989 - "Side effects starting 12 to 24 hours after treatment are similar to those appearing during the normal evolution of onchocerciasis. "
09/01/1993 - "The long-term efficacy of a single dose of ivermectin (150 micrograms/kg) on skin microfilarial densities was evaluated by comparing parasite levels, before and after treatment, in 192 patients living in an area endemic for onchocerciasis in North Cameroon. "
09/01/2011 - "Data from two separate studies conducted in Cameroon on onchocerciasis patients treated for the first time with ivermectin were analyzed to identify host factors associated with microfilarial density at different time-points after treatment. "
12/01/1997 - "Immunohistological studies on macrophages in lymph nodes of onchocerciasis patients after treatment with ivermectin."