Oligosaccharides

Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.

Also Known As:

Networked: 3566 relevant articles (155 outcomes, 446 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Miyoshi, Eiji: 45 articles (12/2021 - 05/2002)
2.	Garssen, Johan: 36 articles (03/2022 - 08/2006)
3.	Bode, Lars: 25 articles (01/2022 - 10/2012)
4.	Commins, Scott P: 17 articles (01/2021 - 05/2011)
5.	Shinzaki, Shinichiro: 17 articles (12/2020 - 05/2008)
6.	Taniguchi, Naoyuki: 15 articles (01/2015 - 02/2002)
7.	Seeberger, Peter H: 14 articles (12/2019 - 02/2004)
8.	Du, Yuguang: 13 articles (01/2022 - 01/2014)
9.	Folkerts, Gert: 13 articles (01/2022 - 04/2014)
10.	Stahl, Bernd: 13 articles (01/2022 - 10/2005)

Related Diseases

1.	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 12/01/2020 - "Human Milk Oligosaccharides Support Normal Bowel Function and Improve Symptoms of Irritable Bowel Syndrome: A Multicenter, Open-Label Trial." 10/01/2020 - "Human milk oligosaccharide supplementation in irritable bowel syndrome patients: A parallel, randomized, double-blind, placebo-controlled study." 11/25/2022 - "The Potential Role of Human Milk Oligosaccharides in Irritable Bowel Syndrome." 10/27/2021 - "Human milk oligosaccharide supplementation safely modulates fecal bifidobacteria abundance and holds the potential to manage symptoms in irritable bowel syndrome (IBS). " 10/27/2021 - "The Effects of Human Milk Oligosaccharides on Gut Microbiota, Metabolite Profiles and Host Mucosal Response in Patients with Irritable Bowel Syndrome."
2.	Inflammation (Inflammations) 10/01/2022 - "This study demonstrates that supplementing an HMO-catabolizing Bifidobacterium probiotic results in increased microbial metabolism of milk oligosaccharides and reduced intestinal inflammation relative to a noncatabolizing Lactobacillus probiotic in human milk-fed preterm infants. " 01/15/2022 - "In this study, we prepared different sizes and structures of HA oligosaccharides and derivatives and investigated the effects on inflammation in vitro and in vivo. " 01/29/2020 - "In this study, oligosaccharides derived from GLPs (D-GLPs) were prepared, and its effect on HFD-induced MS and inflammation was evaluated in mice. " 02/01/2007 - "This review is focused on the most recent studies on the occurrence of different glycoforms in plasma and tissues and how the appearance of different oligosaccharide patterns during systemic inflammation or diseases can influence AGP's biological functions. " 11/16/2023 - "Dietary Chito-oligosaccharide attenuates LPS-challenged intestinal inflammation via regulating mitochondrial apoptotic and MAPK signaling pathway."
3.	Infections 12/01/2014 - "In this study, we develop a concept of rapid-throughput glycomics on human milk oligosaccharides, which have proven to be an important bioactive component of breast milk, providing the infant with protection against pathogenic infection and supporting the establishment of a healthy microbiota. " 01/01/2019 - "Human milk contains an abundant supply and diverse array of oligosaccharides that are known to impart significant health benefits to the nursing infant including establishment and maintenance of a healthy gut microflora, immune development and protection against gastrointestinal infections. " 10/01/2006 - "One year-long trial feeding both galacto-oligosaccharides and HN019 in children 1 to 3 years of age provided evidence for improved growth and reduction in infection incidence. " 05/01/1984 - "These studies prove that oligosaccharide side chain-specific antibody to LPS confers protection against LPS toxicity in vivo and against experimental gram-negative infection. " 06/09/2021 - "Many studies point out a signalling role for EPS-derived oligosaccharides in root infection and nodule invasion but, in certain symbiotic couples, EPS can be dispensable for a successful interaction. "
4.	Diarrhea 04/28/2016 - "The oligosaccharides in human milk constitute a major innate immunological mechanism by which breastfed infants gain protection against infectious diarrhea. " 09/01/2004 - "This study provides novel evidence suggesting that human milk oligosaccharides are clinically relevant to protection against infant diarrhea." 10/01/2022 - "Orally Administered Xylo-Oligosaccharides (XOS) Ameliorates Diarrhea Symptoms in Mice via Intestinal Barrier Improvement and Gut Microbiota Modulation." 09/01/2004 - "Human milk oligosaccharides are associated with protection against diarrhea in breast-fed infants." 01/01/2023 - "In this study, we used an in vitro fermentation system to prevent the interference of host-gut microbe interactions during in vivo examination and investigated the effect of fructo-oligosaccharides (FOS) on gut microbiota composition and metabolism in 39 pediatric patients with functional diarrhea. "
5.	Neoplasms (Cancer) 01/15/1997 - "However, short-chain fructo-oligosaccharides dramatically reduced the incidence of colon tumors and concomitantly developed gut-associated lymphoid tissue. " 08/31/2017 - "Data on galacto-oligosaccharides (GalOS) against CRC are very limited and GalOS used in this study have β-1,6 and β-1,3 as major glycosidic linkages and, to our best knowledge, were never used before against any cancer treatment. " 01/01/2008 - "NMR structural studies of oligosaccharides related to cancer processes." 02/15/1989 - "Secondly, a subset of human breast malignancies showed elevated levels of beta 1-6-branched oligosaccharides compared to benign samples, suggesting that further studies are warranted to determine whether the presence of these oligosaccharides is associated with metastatic disease and reduced patient survival time." 01/01/1988 - "The experiments described in this study examined cell membrane oligosaccharides, malignancy-related cell phenotypes and tumor cell susceptibility to the killing effect of human cytotoxic cells. "

Related Drugs and Biologics

1.	Chitosan
2.	Disaccharides
3.	Monosaccharides
4.	Prebiotics
5.	Proteins (Proteins, Gene)
6.	Mannans
7.	Antibodies
8.	Conjugate Vaccines
9.	Polysaccharides (Glycans)
10.	Vaccines

Related Therapies and Procedures

1.	Therapeutics
2.	Diet Therapy (Therapy, Diet)
3.	Immunotherapy
4.	Drug Therapy (Chemotherapy)
5.	Aftercare (After-Treatment)