Oligoribonucleotides

A group of ribonucleotides (up to 12) in which the phosphate residues of each ribonucleotide act as bridges in forming diester linkages between the ribose moieties.

Networked: 15 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
  - Polynucleotides: 218
    - Oligonucleotides: 5145
      - Oligoribonucleotides: 15
        2',5'-oligoadenylate: 154
        adenylyl-(3'-5')-uridine 3'-monophosphate: 14
        ENKAD: 7
        adenosine diphosphate adenosine monophosphate: 6
        adenylyl-(3'-5')-uridine 5'-phosphate: 6
        oligo(U): 4
        2-5A(N6B): 2
        adenosine triphosphate-2',5'-adenosine monophosphate: 2
        oligo(G): 2
        ISIS-113715: 1
        NOX-H94: 1
        (2'-5')oligoisoadenylate
        (azidoU)UUGUU
        (U)C-A-C-C-A-Leu-Ac
        2',5'-oligoadenyl-5'-diphosphate
        2'-O-(2-methoxyethyl)-RNA
        3'-5'-oligoadenylate
        3'-O-(2-methoxyethyl)-*CG*CGAA*U*U*CG*CG
        4-(N-2-chloroethyl-N-methylamino)benzaldehde octauridylate
        5'-diphosphoadenylyl-guanylyl-adenosine
        5'-monophosphoryladenylyl-(2'-5')adenylyl-(2'-5')-8-bromoadenylyl-(2'-5')-8-bromoadenosine
        5'-r(uridylyl-uridylyl cytidine)
        A(7)U(7)p
        adenosine triphosphate adenosine monophosphate adenosine monophosphate
        adenosine triphosphate uridine monophosphate
        adenosine triphosphate-uridine monophosphate cytidine monophosphate
        adenyl-(3',5')-2'-deoxyfluoroguanylyl-(3',5')-adenosine
        adenylyl (2'-5')-adenylyl-(2'-5')adenosine bis-phosphoramidate
        adenylyl-(3'-5')-adenylyl-(3'-5')-adenylyl-(3'-5')-adenosine
        ApApG
        ApUpG
        beta-alanyltyrosine-2',5'-oligoadenylate 5'-triphosphate
        bis(3'-5'-decathymidylyl)phosphorus(V)tetraphenylporphyrin
        CCdApPuro
        d(ATGCAT)2
        deoxyguanylyl-3'-5'-deoxyuridylic acid
        dicytidylyl-(3'-5')-1,2-di(adenosin-N(6)-yl)ethane
        dicytidylyl-(3'-5')-1,4-di(adenosin-N(6)-yl)butane
        Gp(2'-5')Ap(3'-5') dinucleotide
        GpGpCpUp
        guanylyl-(5'-3')-cytidylyl-(5'-3')-adenosine
        heptauridylic acid
        Hex-S3 oligonucleotide
        N-hexylmorpholine-2',5'-oligoadenylate
        NOX-F37 oligoribonucleotide
        OMUpy2
        P(1)-adenylyl-5'-2'-adenylyl-5'-2'-adenosyl-P(3)-n-decylaminotriphosphate
        r(GCUUCGGC) RNA tetraloop
        ribo-oligonucleotide A(7)
        ribo-oligonucleotide A(7)U(7)
        SBCoV202
        SSO111 oligonucleotide
        tri(cytidylic acid-guanidylic acid)
        triadenylyl-(2'-3')-adenylyl-cytidylic acid
        uridylyl-(3'-5')-adenylyl-(3'-5')uridine
        uridylyl-(3'-5')-uridylyl-(3'-5')-3'-uridylic acid
        VPg-pUpU

Experts

1.	Melnichuk, Nataliia: 2 articles (09/2021 - 08/2017)
2.	Tkachuk, Zenoviy: 2 articles (09/2021 - 08/2017)
3.	Bessert, Denise: 1 article (12/2021)
4.	Hazlett, Linda D: 1 article (12/2021)
5.	Iulianelli, Mason: 1 article (12/2021)
6.	McClellan, Sharon: 1 article (12/2021)
7.	Pitchaikannu, Ahalya: 1 article (12/2021)
8.	Wright, Robert: 1 article (12/2021)
9.	Xu, Shunbin: 1 article (12/2021)
10.	Berghaus, Julia: 1 article (11/2021)

Related Diseases

1.	Urinary Bladder Neoplasms (Bladder Cancer) 11/12/2021 - "Kinetic studies with human bladder cancer-derived synthetic circular RNA versus linear transcripts, respectively, with short oligoribonucleotides showed similar association rates for both topologies. "
2.	Neoplasms (Cancer) 01/01/2015 - "Short loop-targeting oligoribonucleotides antagonize Lin28 and enable pre-let-7 processing and suppression of cell growth in let-7-deficient cancer cells." 08/01/2014 - "We further functionalized this Zn-DPA analog to hyaluronic acid (HA)-based self-assembled nanoparticles (HA-NPs) with a hydrodynamic diameter of 100 nm by conjugating amine-functionalized Zn-DPA molecules onto the HA-NPs through amide formation, resulting in efficient tumor-targeted delivery of RNAs (siRNAs, miRNA or other short oligoribonucleotides) and small-molecule drugs. "
3.	Human Influenza (Influenza) 09/30/2021 - "The natural oligoribonucleotides (ORNs) as well as their derivatives functionalized with D-mannitol (ORNs-D-M) possess anti-influenza properties in vitro and in vivo due to interaction with HA receptor sites. " 08/09/2017 - "The oligoribonucleotides-d-mannitol (ORNs-d-M) complexes possess an anti-influenza activity in vitro and in vivo. " 09/30/2021 - "The Natural Oligoribonucleotides Functionalized by D-Mannitol Affected Interactions of Hemagglutinin with Glycan Receptor Indicating Anti-Influenza Activity."
4.	Vesicular Stomatitis 01/01/2007 - "The 3' terminal genome regions of negative-strand viruses such as vesicular stomatitis virus, Sendai virus, or influenza virus contain a high number of conserved U and G nucleotides, and synthetic oligoribonucleotides encoding such sequences stimulate sequence-dependent cytokine responses via TLR7 and TLR8. "
5.	Mastocytoma 11/01/1991 - "We have developed a two-step purification of the particle from TB21 mouse mastocytoma cell nuclear extracts, with about a 20% overall yield, using affinity binding to 2'-O-methyl oligoribonucleotides. "

Related Drugs and Biologics

1.	Circular RNA
2.	Mannitol (Osmitrol)
3.	Toll-Like Receptor 7
4.	MicroRNAs (MicroRNA)
5.	Cytokines
6.	Polysaccharides (Glycans)
7.	Nucleotides
8.	Nucleosides
9.	Lipids
10.	Hyaluronic Acid (Hyaluronan)