Oligonucleotides

Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)

Networked: 1310 relevant articles (61 outcomes, 95 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Klinman, Dennis M: 15 articles (01/2015 - 05/2004)
2.	Agrawal, Sudhir: 11 articles (08/2007 - 01/2002)
3.	Hartmann, Gunther: 8 articles (01/2012 - 11/2002)
4.	Zhang, Ruiwen: 8 articles (09/2006 - 01/2002)
5.	Wang, Hui: 8 articles (09/2006 - 01/2002)
6.	Shirota, Hidekazu: 7 articles (01/2015 - 10/2004)
7.	Endres, Stefan: 7 articles (01/2012 - 11/2002)
8.	Gilchrest, Barbara A: 7 articles (01/2010 - 02/2003)
9.	Cogoi, Susanna: 6 articles (12/2015 - 01/2007)
10.	Jing, Naijie: 6 articles (05/2014 - 09/2004)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2012 - "To validate the tumor-promoting effect of miR-221, we showed that in vivo delivery of anti-miR-221 oligonucleotides leads to a significant reduction of the number and size of tumor nodules. " 01/01/2008 - "Here we review the key properties of LNA oligonucleotides in the context of their use as safe and effective antisense drugs and provide a status on their therapeutic development in the field of cancer." 03/01/2007 - "These data confirm and expand our earlier work suggesting that such telomere homolog oligonucleotides (T-oligos) target an innate anti-cancer defense system in human cells and may provide an effective treatment for cancers of multiple different cellular origins and genetic profile." 01/01/2004 - "These mechanisms might help us to understand the biodistribution of oligo within tumors and might be helpful in evaluating the therapeutic effects of oligonucleotides and rational drug design." 07/01/2014 - "This review covers research and patent literature from the last three years, focusing on the development of safe and effective non-viral drug delivery systems for the treatment of diseases such as cancer or genetic disorders by using oligonucleotides. "
2.	Infection 03/15/2002 - "However, if APCs were activated concomitantly in vivo using either anti-CD40 Abs or CpG oligonucleotides, the CTL responses induced were fully protective against infection with lymphocytic choriomeningitis virus or recombinant vaccinia virus. " 01/01/2015 - "Sets of virus-specific oligonucleotides and oligofluorophores were designed and used in a reverse-transcription loop-mediated multiplexed isothermal amplification reaction for detection and gel electrophoretic identification of human Immunodeficiency virus (HIV), hepatitis-B virus (HBV), hepatitis-C virus (HCV), hepatitis-E virus (HEV), dengue virus (DENV), and West Nile (WNV) virus infection in blood plasma. " 01/01/2015 - "When MARC-145 cells or PAM were infected with PRRSV followed by transfection with AS-ONs, four AS-ON sequences targeting 5'-UTR, ORF5 or NSP9 were found to be the most effective oligonucleotides in decreasing the cytopathic effect (CPE) induced by PRRSV infection. " 09/01/2014 - "We demonstrate a significant effect on HSV-1 replication in ARPE-19 and Vero cells when oligonucleotides designed to inhibit TLR9 are added 2h prior to infection. " 09/01/2014 - "Oligonucleotides designed to inhibit TLR9 block Herpes simplex virus type 1 infection at multiple steps."
3.	Melanoma (Melanoma, Malignant) 04/15/2008 - "In vitro and in vivo functional studies, including the use of antisense "antagomir" oligonucleotides, confirmed the key role of miR-221/-222 in regulating the progression of human melanoma; this suggests that targeted therapies suppressing miR-221/-222 may prove beneficial in advanced melanoma." 01/01/2015 - "A high-throughput screening assay for the functional delivery of splice-switching oligonucleotides in human melanoma cells." 01/01/2013 - "In accordance, the reverse functional effects were obtained by knocking down miR-126&126* by transfecting antisense LNA oligonucleotides in melanoma cells. " 01/01/2010 - "Inhibition of melanoma angiogenesis by telomere homolog oligonucleotides." 10/01/2000 - "Microsatellite analysis of melanoma lesions using (CA)13 oligonucleotides as an internal probe."
4.	Breast Neoplasms (Breast Cancer) 02/01/2007 - "To confirm these results and explore pathways other than those implicated in breast cancer, for this study we used pangenomic arrays containing 25,000 oligonucleotides. " 07/01/2015 - "This paper mainly focuses on the influence of polymeric chain length on the particle properties and their drug-carrying ability to deliver oligonucleotides into breast cancer cells. " 01/28/2014 - "This AEGIS-SELEX was designed to create AEGIS oligonucleotides that bind to a line of breast cancer cells. " 04/01/2013 - "In ERα-positive and ERα-negative breast cancer cells, proliferative and invasiveness properties were suppressed by hsa-miR-196a2* expression and enhanced by hsa-miR-196a2* antagonism or TP63 target protector oligonucleotides. " 01/01/2012 - "Furthermore, transfection of miR-133a oligonucleotides slightly inhibited growth but significantly decreased migration and invasion capacity of breast cancer cells, compared with negative controls, whereas knockdown of miR-133a expression induced breast cancer cell migration and invasion. "
5.	Communicable Diseases (Infectious Diseases) 10/21/2008 - "in the examination of specific RNA sequences for infectious diseases, however, a major limiting factor in oligonucleotide-based diagnostics is poor cellular uptake of naked oligonucleotides. " 08/01/2005 - "The immunomodulatory oligonucleotides are also being investigated for the potential treatment of infectious diseases and immune disorders." 08/01/2003 - "Modified oligonucleotides continue to play an important role as antisense compounds that inhibit the expression of genes associated with metabolic disorders, cancer, and infectious diseases. " 05/01/2001 - "This antisense strategy has been used to develop therapeutic oligonucleotides against cancer and various infectious diseases in humans. " 03/28/2009 - "CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases."

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	RNA (Ribonucleic Acid)
3.	CPG-oligonucleotide
4.	Antigens
5.	Telomerase (Telomerase Reverse Transcriptase)
6.	Messenger RNA (mRNA)
7.	NF-kappa B (NF-kB)
8.	Antisense Oligonucleotides
9.	Vaccines
10.	Liposomes (Liposome)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Immunotherapy
3.	Drug Therapy (Chemotherapy)
4.	Transplants (Transplant)
5.	Cryosurgery