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Oligo-1,6-Glucosidase (Isomaltase)

An enzyme that catalyzes the endohydrolysis of 1,6-alpha-glucosidic linkages in isomaltose and dextrins produced from starch and glycogen by ALPHA-AMYLASES. EC 3.2.1.10.
Also Known As:
Isomaltase; Exo-Oligo-1,6-Glucosidase; Exo Oligo 1,6 Glucosidase; Oligo 1,6 Glucosidase; Dextrin 6-alpha-D-glucanohydrolase
Networked: 127 relevant articles (0 outcomes, 11 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Naim, Hassan Y: 14 articles (11/2021 - 05/2003)
2. Camilleri, Michael: 4 articles (03/2019 - 06/2012)
3. Bonfiglio, Ferdinando: 3 articles (11/2021 - 01/2018)
4. D'Amato, Mauro: 3 articles (11/2021 - 01/2018)
5. Zheng, Tenghao: 3 articles (11/2021 - 01/2018)
6. Zimmer, Klaus-Peter: 3 articles (09/2019 - 12/2003)
7. Chaves, P: 3 articles (11/2014 - 01/2002)
8. Alfalah, Marwan: 3 articles (03/2009 - 12/2003)
9. Leeb, Tosso: 3 articles (03/2009 - 01/2006)
10. Jacob, Ralf: 3 articles (06/2005 - 05/2003)

Related Diseases

1. Colonic Neoplasms (Colon Cancer)
2. Neoplasms (Cancer)
06/01/2003 - "To investigate whether intestinal differentiated cells, other than goblet cells, are associated to neoplasia we compared the prevalence of enterocytic features in columnar elements with and without associated BA through the use of sucrase-isomaltase (SI) immunoreactivity in 31 columnar esophageal segments (CLES) and 12 BA. "
06/01/1990 - "These results demonstrate that colonic crypt cells and some benign tumor cells synthesize and express at their cell surface a form of sucrase-isomaltase immunologically distinct from that present in the brush borders of small intestinal villose cells."
09/01/2007 - "The monoclonal antibody to sucrase-isomaltase used in this study may have a clinical role when interpreting columnar cuff biopsies from patients being investigated for pouch dysfunction, or in patients having surveillance biopsies to exclude neoplasia in the columnar cuff."
06/29/1998 - "An understanding of the regulatory network of nuclear proteins that direct transcriptional initiation of intestinal genes such as sucrase-isomaltase will provide insight into the mechanisms of normal development and differentiation as well as disease processes such as neoplasia."
03/01/1987 - "Similar results were obtained in the corresponding tumors in nude mice: anti-A antibodies in HT-29 and UEA-I in Caco-2 tumors bound to the same apical structures as did anti-sucrase-isomaltase antibodies; sucrase-isomaltase immunoisolated from the tumors bound anti-A antibodies (HT-29) or UEA-I (Caco-2). "
3. congenital Sucrase-isomaltase deficiency
4. Adenocarcinoma
5. Gastrointestinal Diseases (Functional Gastrointestinal Disorders)

Related Drugs and Biologics

1. Sucrase (Sucrose alpha-D-Glucohydrolase)
2. Hydrolases
3. Messenger RNA (mRNA)
4. Enzymes
5. Disaccharidases
6. CD13 Antigens (Alanine Aminopeptidase)
7. Monoclonal Antibodies
8. Glucose (Dextrose)
9. Lactase-Phlorizin Hydrolase
10. Antibodies

Related Therapies and Procedures

1. Colonic Pouches (S Pouch)
2. Transjugular Intrahepatic Portasystemic Shunt
3. Ileostomy
4. Colectomy