Oleanolic Acid

A pentacyclic triterpene that occurs widely in many PLANTS as the free acid or the aglycone for many SAPONINS. It is biosynthesized from lupane. It can rearrange to the isomer, ursolic acid, or be oxidized to taraxasterol and amyrin.

Also Known As:

Networked: 228 relevant articles (15 outcomes, 35 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gautam, Subhash C: 7 articles (01/2013 - 09/2007)
2.	Gao, Xiaohua: 7 articles (01/2013 - 09/2007)
3.	Deeb, Dorrah: 7 articles (01/2013 - 09/2007)
4.	Zhang, Yihua: 6 articles (06/2013 - 08/2008)
5.	Arbab, Ali S: 6 articles (01/2013 - 02/2010)
6.	Dulchavsky, Scott A: 6 articles (11/2011 - 09/2007)
7.	Nieto, María Luisa: 5 articles (04/2015 - 04/2007)
8.	Wu, Ning: 5 articles (08/2014 - 10/2012)
9.	Lin, Xiukun: 5 articles (08/2014 - 10/2012)
10.	Liu, Yongbo: 5 articles (01/2013 - 09/2007)

Related Diseases

1.	Neoplasms (Cancer) 02/13/2013 - "Synthesis of novel heterocyclic oleanolic acid derivatives with improved antiproliferative activity in solid tumor cells." 01/01/2014 - "In this study, we found that Oleanolic acid (OA) induced a switch from PKM2 to PKM1, and consistently, abrogated Warburg effect in cancer cells. " 10/01/2015 - "The results revealed that oleanolic acid induced a dose‑dependent, as well as time‑dependent inhibition in the growth of HepG2 cancer cells. " 10/01/2015 - "Oleanolic acid (OA) derivatives exhibit numerous pleiotropic effects in many cancers. " 04/01/2015 - "[Synthesis and anti-tumor activity of oleanolic acid derivatives]."
2.	Inflammation 01/01/2016 - "Oleanolic acid acetate (OAA), a compound isolated from Vigna angularis, has been known to possess pharmacological activities, including anti-inflammation and anti-bone destruction. " 02/01/2013 - "Anti-inflammatory effects of oleanolic acid on LPS-induced inflammation in vitro and in vivo." 02/15/2006 - "Synthetic triterpenoid analogues of oleanolic acid are potent inducers of the phase 2 response as well as inhibitors of inflammation. " 05/01/1992 - "Oleanolic acid checked the inflammation-induced increased serum transaminase levels. " 01/01/2014 - "We investigated the effects of oleanolic acid, a known Nrf2 activator, on oxidative stress-induced renal inflammation and fibrosis. "
3.	Hyperglycemia 01/01/2012 - "The present study investigated the chronic efficacy of oleanolic acid (OA), a triterpenoid selected from our recent screening, on hyperglycemia in type-2 diabetic mice. " 01/01/2014 - "Our recent study (referred as Study 1) showed that the triterpenoid oleanolic acid (OA) was able to produce a sustained correction of hyperglycemia beyond treatment period in type 2 diabetes (T2D) mice with liver as a responsible site. " 01/01/2012 - "Oleanolic acid: a novel cardioprotective agent that blunts hyperglycemia-induced contractile dysfunction." 01/01/2012 - "Oleanolic acid reduces hyperglycemia beyond treatment period with Akt/FoxO1-induced suppression of hepatic gluconeogenesis in type-2 diabetic mice." 01/01/2015 - "Here we report that TGR5 is involved in mediating the anti-obesity and anti-hyperglycemia effect of a natural compound, oleanolic acid. "
4.	Pain (Aches) 01/01/2006 - "Mice were pretreated orally with oleanolic acid (3, 10, 30 mg/kg) or vehicle, and the pain-related behavioral responses to intracolonic injection of mustard oil was analysed. " 10/01/2005 - "The aim of this open-label, 8-week observational trial was to investigate the efficacy of Meta050 (a proprietary, standardized combination of reduced iso-alpha-acids from hops, rosemary extract and oleanolic acid) on pain in patients with rheumatic disease. " 07/01/2013 - "The results indicate that oleanolic acid shows an antinociceptive property in various pain models such as writhing, formalin, substance P and glutamate pain tests. " 04/01/2009 - "The hexane fraction derivatives baurenol, alpha-spinasterol and oleanolic acid (0.00001-10 mg/kg intraperitoneally) also caused potent inhibition of acetic acid-induced pain. "
5.	Prostatic Neoplasms (Prostate Cancer) 05/01/2011 - "In an extension of our previous studies showing potent antitumorigenic activity of synthetic triterpenoids of oleanolic acid against prostate cancer cell lines, we examined the efficacy of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO) in preventing the development and/or progression of prostate cancer in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model. " 01/01/2011 - "2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO), a synthetic analog of oleanolic acid, and its C28 methyl ester derivative (CDDO-Me), have shown potent antitumorigenic activity against a wide range of cancer cell lines, including prostate cancer cells in vitro, and inhibited the development of liver and lung cancer in vivo. "

Related Drugs and Biologics

1.	ursolic acid
2.	Acids
3.	Enzymes
4.	1-Butanol (n Butanol)
5.	Isoproterenol (Isoprenaline)
6.	Bradykinin
7.	lespenefril
8.	ethyl acetate
9.	Nitric Oxide (Nitrogen Monoxide)
10.	Liposomes (Liposome)

Related Therapies and Procedures

1.	Radiotherapy
2.	Ligation
3.	Chemoprevention
4.	Parenteral Nutrition
5.	Ovariectomy (Oophorectomy)