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Odontoma

A mixed tumor of odontogenic origin, in which both the epithelial and mesenchymal cells exhibit complete differentiation, resulting in the formation of tooth structures. (Jablonski, Illustrated Dictionary of Dentistry, 1982)

Also Known As:

Fibro-Odontoma; Fibroodontoma; Ameloblastic Fibro-odontoma; Ameloblastic Fibro-odontomas; Compound Odontoma; Compound Odontomas; Fibro Odontoma; Fibro odontoma, Ameloblastic; Fibro-Odontomas; Fibro-odontomas, Ameloblastic; Fibroodontomas; Odontomas; Odontomas, Compound; Fibro-odontoma, Ameloblastic; Odontoma, Compound

Networked: 120 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Neoplasms: 649836
- Neoplasms by Histologic Type: 1
  - Odontogenic Tumors: 304
    - Odontoma: 120
      - Odontoma dysphagia syndrome

Related Diseases

1.	Adamantinoma
2.	Odontogenic Tumors (Dental Tissue Neoplasm)
3.	Ameloblastoma
4.	Fibroma (Fibromatosis)
5.	Myxoma (Myxomas)

Experts

1.	Favia, G: 3 articles (11/2007 - 12/2000)
2.	Pavoni, Chiara: 2 articles (07/2013 - 07/2012)
3.	Cozza, Paola: 2 articles (07/2013 - 07/2012)
4.	Laganà, Giuseppina: 2 articles (07/2013 - 07/2012)
5.	Ide, Fumio: 2 articles (10/2008 - 08/2007)
6.	Kusama, Kaoru: 2 articles (10/2008 - 08/2007)
7.	Szabó, György: 2 articles (11/2007 - 04/2007)
8.	Di Bisceglie, M B: 2 articles (11/2007 - 05/2006)
9.	Gyulai-Gaál, Szabolcs: 2 articles (11/2007 - 04/2007)
10.	Lucchese, A: 2 articles (11/2007 - 05/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Odontoma:

1.	Melanins (Melanin)IBA 09/01/1989 - "The possible histogenesis of melanin pigment in odontogenic lesions was discussed, although no conclusion could be drawn from the present study as to its origin in complex odontoma." 09/01/1989 - "In addition to the characteristic histopathologic features of complex odontoma, ghost cells containing melanin pigment were widely distributed in and around the calcified masses. " 09/01/1989 - "A case of complex odontoma, which contained melanin pigment in the ghost cells in a 53-year-old Japanese woman is reported. " 09/01/1989 - "Melanin pigment in ghost cells of a complex odontoma." 08/01/1988 - "Pigmented ameloblastic fibro-odontoma: detection of melanin pigment in enamel."
2.	AdenoameloblastomaIBA 01/01/2013 - "We describe a case of adenomatoid odontogenic tumor (AOT) associated with odontoma occurring in the posterior mandible of a 32-year-old man. " 01/01/2013 - "Adenomatoid odontogenic tumor associated with odontoma: a case report and critical review of the literature." 10/01/2009 - "This case report describes a 10-year-old female patient with an adenomatoid odontogenic tumor developing together with a cystic complex odontoma. " 10/01/2009 - "Adenomatoid odontogenic tumor concomitant with cystic complex odontoma: case report." 09/01/2008 - "The histopathologic findings were consistent with concurrent occurrence of an odontoma and adenomatoid odontogenic tumor."
3.	AmelogeninIBA 09/01/2001 - "The secretion of amelogenins is associated with the induction of enamel and dentinoid in an ameloblastic fibro-odontoma." 01/01/1991 - "Reduced ameloblasts in the odontoma displayed the strongest staining for amelogenins. " 06/01/2013 - "We immunohistochemically evaluated the expression of Tβ4, ameloblastin (AMBN), amelogenin (AMEL) and enamelin (ENAM) in 57 samples of ameloblastomas from 40 patients, and also assessed the expression of these molecules in 11 cases of odontomas, two of ameloblastic fibro-odontomas and one of tooth germ-like structures without the formation of enamel and dentin. " 09/01/2001 - "In odontogenic tumors, positive reactions for amelogenin were localized in limited areas in adenomatoid odontogenic tumor, calcifying odontogenic cyst, primary intraosseous carcinoma and odontoma. " 03/01/2012 - "In this study, we have examined the presence and distribution of odontogenic ameloblast-associated protein (ODAM), amelotin (AMTN), ameloblastin (AMBN), and amelogenin (AMEL) by immunohistochemistry in samples of adenomatoid odontogenic tumor (AOT), calcifying epithelial odontogenic tumor (CEOT), developing odontoma, ameloblastoma, calcifying cystic odontogenic tumor (CCOT), ameloblastic fibroma (AF), myxoma, odontogenic fibroma (OF), and reduced enamel epithelia (REE). "
4.	Calcifying Epithelial Odontogenic TumorIBA 02/01/2005 - "More cases of malignant odontogenic tumors were seen than cases of calcifying epithelial odontogenic tumor and odontomas. " 01/01/2014 - "Three types of human odontogenic tumors histologically classified as compound composite odontoma, ossifying fibroma, and Pindborg tumor were characterized using mid-infrared spectroscopy (mid-IR) and solid-state nuclear magnetic resonance (ssNMR). " 12/01/2000 - "Radiologically, focal sclerosing osteitis, cementoblastoma, cementifying and ossifying fibroma, periapical cemental dysplasia, complex odontoma, and calcifying epithelial odontogenic tumor should be considered in the differential diagnosis. " 05/01/2007 - "Mean age of the whole population was 12.7 years and the male to female ratio was 2:1. The most frequent tumor types were Odontoma, (50.9%), Ameloblastoma (18.3%) and Myxoma (8.5%), and the most infrequent was Calcifying Epithelial Odontogenic Tumor (1.3%). " 07/01/1997 - "Eight types of odontogenic tumors (44 cases), including ameloblastoma (20 cases), cementifying fibroma (8 cases), benign cementoblastoma (5 cases), dentinoma (3 cases), compound odontoma (2 cases), adenomatoid odontogenic tumor (2 cases), calcifying epithelial odontogenic tumor (2 cases) and odontogenic fibroma (2 cases), were studied. "
5.	PlasticsIBA 04/01/1998 - "Histochemical evaluation of alkaline phosphatase in compound odontoma: a study of plastic embedded undemineralized material."
6.	Alkaline PhosphataseIBA 04/01/1998 - "Histochemical evaluation of alkaline phosphatase in compound odontoma: a study of plastic embedded undemineralized material."
7.	Radio-Opaque acrylic resin (Boston Post)IBA 06/01/2013 - "They generally appear as small, solitary or multiple radio-opaque lesions on routine radiographic examinations and are subdivided into complex or compound odontomas morphologicaly. " 05/01/2012 - "CT was superior to conventional radiographs in detecting buccolingual expansion, odontomas and radio-opaque bodies. " 11/01/2007 - "Compound odontomas (CDOs) usually appear in the maxilla, in the region of the incisors and canines and contain small, radio-opaque structures reminiscent of rudimentary teeth. " 04/01/2007 - "Compound odontomas (CDOs) usually appear in the maxilla, in the region of the incisors and canines, and contain small, radio-opaque structures reminiscent of rudimentary teeth. " 01/01/2007 - "Odontomas generally appear as small, solitary or multiple radio-opaque lesions found on routine radiographic examinations. "
8.	TaurodontismIBA 10/01/2013 - "The orthopantomographs (OPGs) and dental records were examined for any unusual finding such as congenitally missing teeth, impactions, ectopic eruption, supernumerary teeth, odontoma, dilacerations, taurodontism, dens in dente, germination and fusion, among others. " 01/01/2012 - "The prevalence of congenitally missing teeth was 226 (25.7%), impacted teeth 186 (21.1%), dilacerated teeth 10 (1.1%), supernumerary teeth 3 (0.3%), odontoma 1 (0.1%), and taurodontism was also 1 case (0.1%) of the total radiographs reviewed. " 08/01/1991 - "An unusual case is presented of three dental developmental anomalies, a hypomaturation-hypoplastic with taurodontism form of amelogenesis imperfecta, hypodontia of the premolars and an odontoma, occurring in an otherwise normal boy."
9.	bromfenacoum (Talon)IBA 09/01/2014 - "All PDTs associated with a supernumerary permanent tooth were type IV. Dental anomalies/pathologies such as odontoma, talon cusp were observed. " 03/01/2004 - "Some synonyms for talon cusp are dens evaginatus of anterior teeth, interstitial cusp, tuberculated tooth, odontoma of the axial core type, evaginated odontoma, enamel pearl, supernumerary cusp etc. The lingual location on incisors, which frequently affects occlusion, is pathognomonic of the talon cusp. " 02/01/2004 - "Talon cusp has been associated with other dental anomalies such as dens invaginatus, odontomas, and impacted teeth; associations with somatic anomalies such as Mohr's, Rubenstein-Taybi, and Sturge-Weber syndromes have also been reported. "
10.	TitaniumIBA 07/01/2011 - "Maxillary reconstruction with particulate bone graft and titanium mesh: a treatment option for large complex odontoma of the maxilla." 09/01/2013 - "In this paper, the authors describe, through the report of a case of complex odontoma located in the mandibular angle, a more conservative surgical technique called corticotomy, in which the bone removed for access to the tumor (buccal cortical) is repositioned and fixed by titanium plates of 1.5 mm. "

Therapies and Procedures

1.	X-Ray Therapy 04/15/1977 - "X-ray therapy was used on 14 selected adamantinomas and 2 ameloblastic odontomas, with beneficial results. "
2.	Oral Surgery (Maxillofacial Surgery) 09/01/2010 - "Twenty six patients, 2 to 14 years of age (mean 9.3 years), with odontomas treated during the years 1999-2008 at the Department of Oral & Maxillofacial Surgery of a Children's Hospital, were included in the study. " 12/01/1999 - "A 14-year retrospective study was performed on 47 odontomas from the files of the 1st Department of Oral and Maxillofacial Surgery at Nihon University School of Dentistry. " 04/01/1980 - "A total of 218 operative removals of odontomas took place in the Department of Oral Surgery, Royal Dental College in the years 1952-1974; 49 of these were localized directly in relation to an impacted tooth and were considered as the cause of impaction. "
3.	Palatal Expansion Technique 07/01/2012 - "The improvement of the intraosseus position of the unerupted incisor, obtained by removal of the odontoma and rapid maxillary expansion, permits a conservative surgery and the achievement of an excellent esthetics and periodontal result." 07/01/2014 - "The treatment plan consisted of three stages: removal of the odontoma; rapid maxillary expansion (RME) in order to improve the intraosseous tooth position; surgical exposure and orthodontic traction of the impacted central incisor to its right position. " 07/01/2013 - "The purpose of this study was to assess the effectiveness of rapid maxillary expansion (RME) vs simply monitoring the eruption of permanent maxillary incisors following the surgical removal of obstacles to their eruption (supernumerary teeth, odontomas). "
4.	Traction 12/01/2010 - "The odontoma was surgically removed and unerupted central incisor was placed in orthodontic traction over a period of 8 months. " 06/01/1997 - "Following surgical removal of the odontoma, the molar was exposed and brought to a proper position by orthodontic traction. " 07/01/2014 - "The treatment plan consisted of three stages: removal of the odontoma; rapid maxillary expansion (RME) in order to improve the intraosseous tooth position; surgical exposure and orthodontic traction of the impacted central incisor to its right position. " 11/01/2015 - "In the case of odontomas associated to impacted teeth, the teeth should be preserved in wait of spontaneous eruption, or alternatively fenestration followed by orthodontic traction is indicated. " 01/01/2005 - "Treatment consisted of surgical removal of odontomas in all cases, after which if the impacted teeth did not erupt, exposure of the crown and/or orthodontic traction was performed. "
5.	Osteotomy 05/01/2014 - "In this article, the authors show a case in which the sagittal osteotomy of the mandible was used to gain access for removal of a lesion (complex odontoma). " 04/01/2010 - "Removal of large complex odontoma using Le Fort I osteotomy." 09/01/2009 - "Removal of large complex odontoma using Le Fort I osteotomy." 12/01/2006 - "Removal of a large odontoma by sagittal split osteotomy." 01/01/1999 - "An unusual treatment with sagittal split osteotomy: report of a case involving an odontoma."