Odontogenic Cysts (Keratocyst)

Cysts found in the jaws and arising from epithelium involved in tooth formation. They include follicular cysts (e.g., primordial cyst, dentigerous cyst, multilocular cyst), lateral periodontal cysts, and radicular cysts. They may become keratinized (odontogenic keratocysts). Follicular cysts may give rise to ameloblastomas and, in rare cases, undergo malignant transformation.

Also Known As:

Networked: 433 relevant articles (6 outcomes, 95 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Radicular Cyst
2.	Cysts
3.	Ameloblastoma
4.	Dentigerous Cyst
5.	Odontogenic Cysts (Keratocyst)

Experts

1.	Kubota, Y: 6 articles (05/2009 - 06/2000)
2.	Shirasuna, K: 6 articles (05/2009 - 06/2000)
3.	Kaplan, Ilana: 5 articles (04/2015 - 11/2004)
4.	de Souza, Lélia Batista: 5 articles (03/2012 - 07/2004)
5.	Ninomiya, T: 5 articles (05/2009 - 06/2000)
6.	Zhong, Ming: 5 articles (12/2004 - 07/2002)
7.	Wang, Jie: 5 articles (12/2004 - 07/2002)
8.	Anavi, Yakir: 4 articles (04/2015 - 10/2005)
9.	de Almeida Freitas, Roseana: 4 articles (11/2013 - 07/2004)
10.	Oka, S: 4 articles (10/2005 - 06/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Odontogenic Cysts:

1.	NitrogenIBA 10/01/2005 - "Based on these results, the combination of enucleation and liquid nitrogen cryotherapy offers patients improved therapy in the management of recurrent odontogenic keratocysts of the jaw, with lower recurrence and avoidance of ostectomy, which is likely to be accepted by the patients." 07/01/2001 - "Based on these results, the combination of enucleation and liquid nitrogen cryotherapy may offer patients improved therapy in the management of odontogenic keratocysts." 10/01/2005 - "10 patients with recurrent odontogenic keratocyst of the jaw were treated with enucleation and liquid nitrogen cryosurgery between 1994 and 2000. " 08/01/2003 - "The use of liquid nitrogen cryotherapy in the management of the odontogenic keratocyst." 07/01/2001 - "The use of enucleation and liquid nitrogen cryotherapy in the management of odontogenic keratocysts."
2.	Keratins (Keratin)IBA 03/01/2015 - "Although numerous investigators have studied the pattern of keratin expression in different odontogenic cysts, the results have been variable. " 01/01/2015 - "A total of 58 keratin-producing odontogenic cysts, diagnosed over ten years and classified according to the WHO 2005 criteria, were immunohistochemically analyzed in terms of CCD1 expression, which was quantified in the basal, suprabasal and intermediate/superficial epithelial compartments. " 04/01/2014 - "From 20 cases containing keratin in the cytological analyses, 19 were KCOTs and one was an orthokeratinized odontogenic cyst (OOC). " 12/01/2010 - "The expression of these GLI2- or keratin 17-related factors was not significantly observed in orthokeratinized odontogenic cysts. " 12/01/2007 - "To report two cases of glandular odontogenic cyst and examine its cytokeratin 18,19 expression. "
3.	Proliferating Cell Nuclear Antigen (PCNA)IBA 04/01/1994 - "The aim of this study was to investigate the reactivity of the epithelial linings of the three major types of odontogenic cyst with a monoclonal antibody to proliferating cell nuclear antigen (PCNA; clone PC10). " 02/01/1996 - "Positive staining with proliferating cell nuclear antigen was seen in all keratocysts; in addition, there was a significant difference in proliferating cell nuclear antigen positivity between the syndrome and nonsyndrome keratocysts. " 02/01/1996 - "Proliferating cell nuclear antigen staining in syndrome and nonsyndrome odontogenic keratocysts." 04/01/1994 - "These results demonstrate differences in PCNA expression between the epithelial linings of the major odontogenic cyst types, indicating differences in proliferative and differentiation processes within these lesions." 05/01/2008 - "PCNA expression was significantly greater in the basal layer of radicular cysts and in the suprabasal layer of odontogenic keratocysts; the percentage of p53 positive cells was significantly greater in the suprabasal layer of odontogenic keratocysts. "
4.	nucleolar organizer region associated proteinsIBA 10/01/2013 - "To evaluate the morphometry of AgNORs in odontogenic cysts and to compare their biologic behavior to determine whether AgNOR morphometry is helpful in predicting the behavior. " 10/01/2013 - "Morphometric evaluation of AgNORs in odontogenic cysts." 02/01/2003 - "The number of AgNORs was also significantly higher (P <.005) in the nuclei of basal layer cells of the epithelial lining of keratocysts than in the nuclei of parabasal layer cells. " 02/01/2003 - "The present study aimed to assess the usefulness of argyrophilic nucleolar organizer regions (AgNORs) as quantitative criteria in the diagnosis of odontogenic cysts and tumors. " 09/01/1996 - "The aim of this study was to determine whether nucleolar organizer regions (AgNORs) may be of value in distinguishing various odontogenic cysts from the unicystic ameloblastoma. "
5.	ParaffinIBA 05/01/2011 - "This study was carried out on 34 archival paraffin-embedded specimens of odontogenic cysts. " 10/01/2010 - "Thirty paraffin blocks of diagnosed odontogenic cysts were processed to determine the immunohistochemical expression of P53 protein. " 02/01/2013 - "The purpose of this study was to analyze SD-1 expression profile immunohistochemically in archival, paraffin-embedded tissue sections of ameloblastomas and in common odontogenic cysts arising from the same locale. " 10/01/2015 - "Eighty-one paraffin-embedded specimens of odontogenic tumors, including ameloblastoma and keratocystic odontogenic tumor, and thirty-two odontogenic cysts were used for immunohistochemical analysis. " 11/01/2013 - "Sixty samples of paraffin embedded tissue specimens (archival tissues) were included (15 radicularcysts, 15 odontogenic keratocysts; 15 dentigerous cysts and15 Ameloblastoma. "
6.	CollagenIBA 01/01/2012 - "A quantitative and qualitative comparative analysis of collagen fibers to determine the role of connective tissue stroma on biological behavior of odontogenic cysts: A histochemical study." 03/01/2011 - "This technique can be used to study the nature of collagen fibres in odontogenic cyst walls. " 03/01/2011 - "Evaluation of collagen in connective tissue walls of odontogenic cysts--a histochemical study." 01/01/2012 - "To investigate, compare and correlate different types and pattern of collagen fibers in odontogenic cysts using picrosiriusred stain under polarizing microscopy in order to delineate its exact role in biological behavior of these lesions. " 11/01/2011 - "Differences in collagen fibres in the capsule walls of parakeratinized and orthokeratinized odontogenic cysts."
7.	Formaldehyde (Formol)FDA Link 03/01/2015 - "In this study, 70 formalin-fixed, paraffin-embedded tissue blocks of odontogenic lesion consisting of 16 unicystic ameloblastomas (UA), 17 solid ameloblastomas (SA), 18 odontogenic keratocysts (OKC), and 19 dentigerous cysts (DC) were reviewed using immunohistochemistry for Twist staining. " 01/01/2015 - "Our study covered 90 formalin fixed paraffin embedded tissue samples: 26 primary cases each of radicular cysts (RC), dentigerous cysts (DC) and odontogenic keratocysts (OKC) and 12 of recurrent OKCs. " 03/01/2011 - "The material for the study included 51 formalin-fixed paraffin-embedded tissue blocks (15 odontogenic keratocyst, 15 dentigerous cysts, 15 radicular cysts and four normal mucosa and two dental follicular tissue as controls), retrieved from the Department of Oral Pathology and Microbiology, MCODS, Manipal. " 09/01/2010 - "four micrometers, formalin-fixed, paraffin-embedded tissue sections from 11 odontogenic keratocysts, 10 dentigerous cysts, 10 radicular cysts and 10 ameloblastomas were immunohistochemically studied. " 07/01/1999 - "The expression of p53 and MDM2 proteins was determined immunohistochemically in 51 formalin-fixed, paraffin embedded specimens of odontogenic cysts and tumours. "
8.	Cyclin D1IBA 03/01/2013 - "Cyclin D1 did show a higher staining intensity in UAs compared to the keratocysts, although the expression of P16 was similar in the studied groups. " 01/01/2013 - "Cyclin d1 expression in odontogenic cysts." 07/01/1999 - "All sporadic odontogenic keratocysts were negative for p53 and cyclin D1. " 03/01/2013 - "Immunohistochemical comparison of cyclin D1 and P16 in odontogenic keratocyst and unicystic ameloblastoma." 08/01/2012 - "Evaluation of Ki-67 and cyclin D1 expression in odontogenic keratocysts and orthokeratinised jaw cysts."
9.	calretininIBA 06/01/2003 - "Calretinin expression in odontogenic cysts." 12/01/2013 - "Evaluation of Calretinin expression in Ameloblastoma and Non-Neoplastic Odontogenic Cysts - An immunohistochemical study. " 12/01/2013 - "Evaluation of Calretinin expression in Ameloblastoma and Non-Neoplastic Odontogenic Cysts - An immunohistochemical study." 06/01/2003 - "However in 8 of 12 parakeratinized keratocysts, there was a positivity to calretinin in the parabasal-intermediate layers of the cyst epithelium. " 06/01/2003 - "The purpose of this study was to evaluate calretinin expression in radicular cysts, follicular cysts, orthokeratinized keratocysts, and parakeratinized keratocysts. "
10.	C.I. direct red 80IBA 04/01/2011 - "Stromal differences in odontogenic cysts of a common histopathogenesis but with different biological behavior: a study with picrosirius red and polarizing microscopy." 10/01/1999 - "Collagen fibres in the wall of odontogenic keratocysts: a study with picrosirius red and polarizing microscopy." 10/01/1999 - "The collagen in the walls of 15 keratocysts was studied histochemically by staining sections with picrosirius red and examining them with polarizing microscopy. " 04/01/2011 - "The collagen in the wall of 11 odontogenic keratocysts, 14 dentigerous cysts and 14 radicular cysts was studied histochemically by staining sections with picrosirius red and examining under polarizing microscope. " 03/01/2011 - "The purpose of this study was to evaluate the nature of collagen in the connective tissue walls of odontogenic cysts, like the odontogenic keratocyst (OKC), dentigerous cyst and radicular cyst using picrosirius red stained sections. "

Therapies and Procedures

1.	Cryotherapy (Therapy, Cold) 11/01/1988 - "A comparative study of treatment of keratocysts by enucleation or enucleation combined with cryotherapy. " 11/01/1988 - "In the present study, the recurrence rates found after treatment of keratocysts by enucleation or enucleation combined with cryotherapy are compared. " 10/01/2004 - "Sixteen patients with posterior mandibular lesions (15 odontogenic keratocysts and 1 fibromyxoma) in close proximity to the inferior alveolar nerve were treated with a standardized enucleation and cryotherapy technique. " 10/01/2005 - "Based on these results, the combination of enucleation and liquid nitrogen cryotherapy offers patients improved therapy in the management of recurrent odontogenic keratocysts of the jaw, with lower recurrence and avoidance of ostectomy, which is likely to be accepted by the patients." 07/01/2001 - "Based on these results, the combination of enucleation and liquid nitrogen cryotherapy may offer patients improved therapy in the management of odontogenic keratocysts."
2.	Decompression 08/01/2011 - "Decompression is effective in reducing odontogenic cysts. " 04/01/2015 - "All consecutive odontogenic cysts occurring in children and treated by decompression from 1994 to 2009 at 1 maxillofacial center were included in the present study. " 08/01/2011 - "The aim of this study was to evaluate the effectiveness of decompression as the initial treatment for odontogenic cysts. " 03/01/2006 - "The objective of this study was to report our experience with the treatment of 30 odontogenic keratocyst (OKC) patients with a conservative treatment protocol based on decompression with reference to the recurrence rate. " 08/01/1996 - "The purpose of this study was to determine the course of healing, the frequency of recurrence, and the changes in the epithelium of keratocysts after decompression treatment. "
3.	Oral Pathology 03/01/2013 - "As demographic information is lacking in Iran and specially in Isfahan, the aim of this study was to determine the prevalence of odontogenic cysts according to age, gender and affected area among patients referring to the Oral Pathology Department of the Dental School of Isfahan University of Medical Sciences (Iran) over a 23-year period. " 08/01/2011 - "In this study, a series of 10 cases of botryoid odontogenic cysts retrieved from the archives of the Postgraduation Program in Oral Pathology, Federal University of Rio Grande do Norte (Brazil), were reviewed for epidemiologic data, clinical presentation, radiographic and histopathologic characteristics, treatment, and recurrence." 03/01/2013 - "A total of 7412 diagnosed lesions recorded in the Oral Pathology Department archives of Isfahan Dental School between 1988 and 2010 were reevaluated, then odontogenic cysts were separated through reviewing microscopic slides according to the 2005 World Health Organization classification and variables such as age, gender, the infected jaw, and its specific region were obtained by SPSS Version 16.0 from the recorded database. " 09/01/2008 - "Data of odontogenic cysts diagnosed from 1985 to 2005 were collected from the files of the Oral Pathology Laboratory of Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil, and entered in a standardized form for later comparisons. " 04/01/1998 - "This retrospective study examined 239 odontogenic keratocysts received by the Oral Pathology Laboratory at Temple University School of Medicine over a 3-year period. "
4.	Oral Surgery (Maxillofacial Surgery) 03/01/1989 - "In this paper a retrospective clinicostatistical study of 508 cases of odontogenic cysts of the jaws treated at the Department of Oral and Maxillofacial Surgery of the University of Athens during the last ten years 1977-1987 is undertaken, in order to evaluate their frequency and other aspects of clinical and therapeutic interest. " 11/01/1981 - "The clinical and histological data of 106 keratocysts from the files of the Department of Oral and Maxillofacial Surgery in Nijmegen and Arnhem, The Netherlands, formed the basis of this study. " 09/01/2010 - "To determine the relative incidence of odontogenic cysts and to identify the main clinicopathological features among patients treated in the Oral Surgery Department of the Dental Clinic of the University of Barcelona (Spain). " 06/01/1999 - "The authors present a series of 40 odontogenic keratocysts treated between 1985 and 1996 by the Division of Maxillofacial Surgery at Turin University. " 01/01/1991 - "A survey is given of patients with odontogenic keratocysts in childhood and adolescence which were treated at the Clinic for Maxillofacial Surgery Tübingen in the last 10 years. "
5.	Cystectomy 01/01/2005 - "On the basis of a case report it was the aim of the authors to present the surgical treatment of odontogenic, recurrent keratocysts at the Clinic for Maxillo-Facial Surgery, University Hospital Zurich, from the primary operation following the Brosch-procedure in 1971 up to the latest cystectomy in 2004." 06/01/1999 - "From a therapeutic point of view, keratocysts localised in a mandibular site were managed using cystectomy in 19 cases and in 18 cases this was followed by marsupialisation. " 10/01/1998 - "He had had a cystectomy for an odontogenic keratocyst 4 years ago. " 04/01/1977 - "[Radiological interpretation of bone regeneration after cystectomy of odontogenic cysts]." 12/01/1968 - "[Treatment of large odontogenic cysts: modified cystectomy methods]."