Night Blindness (Nyctalopia)

01/01/1976 - " Administration of 200,000 IU of vitamin A every 4 months completely eliminated night blindness and prevented the development of new cases of Bitot's spot in a statistically significant number of children. "
01/01/1976 - "Administration of 200,000 IU of vitamin A every 4 months completely eliminated night blindness and prevented the development of new cases of Bitot's spot in a statistically significant number of children. "
01/01/2010 - "Vitamin A supplementation reduces the risk of maternal night blindness (risk ratio (RR) 0.70, 95% CI 0.60 to 0.82, 1 trial Nepal). "
04/01/2008 - "We compared birthweight, 6-mo infant mortality, morbidity, and growth among infants of women who did and did not report a history of night blindness from a community-based, randomized trial of newborn vitamin A supplementation in south India. "
03/01/2004 - "This study validates different definitions of reported night blindness (XN) in a vitamin A deficient African population with no local term for XN. "

05/18/2011 - "Vitamin A compared with either placebo or beta carotene supplementation increased plasma retinol concentrations by end of study (1.46 [95% CI, 1.42-1.50] μmol/L vs 1.13 [95% CI, 1.09-1.17] μmol/L and 1.18 [95% CI, 1.14-1.22] μmol/L, respectively; P < .001) and reduced, but did not eliminate, gestational night blindness (7.1% for vitamin A vs 9.2% for placebo and 8.9% for beta carotene [P < .001 for both]). "
05/01/2001 - "Stratified analysis by maternal night blindness status during pregnancy was done for 10,000 women participating in a randomized, placebo-controlled trial of vitamin A and beta-carotene supplementation. "
09/15/2000 - "The authors assessed the risk of maternal death during and after a pregnancy with night blindness among women participating in a cluster-randomized, placebo-controlled vitamin A and beta-carotene supplementation trial in Nepal from July 1994 to September 1997. "
09/15/2000 - "In comparison, the relative risk of dying among nonnight-blind women in the placebo group was 0.26 (95% confidence interval (CI): 0.13, 0.55), and the relative risk among women with or without night blindness in the vitamin A/beta-carotene group was 0.32 (95% CI: 0.10, 0.91) and 0.18 (95% CI: 0.09, 0.36), respectively. "
09/15/2000 - "Night blindness during pregnancy and subsequent mortality among women in Nepal: effects of vitamin A and beta-carotene supplementation."

11/01/2006 - "Improvement of scotopic electroretinograms and night blindness with recovery of serum zinc levels."
07/01/2008 - "Zinc therapy for night blindness in cystic fibrosis."
05/01/2005 - "Summary statistics on iron deficiency anemia, night blindness, and risk of zinc deficiency are summarized."
06/01/2001 - "Zinc deficiency may result in abnormal dark adaptation or night blindness, a symptom primarily of vitamin A deficiency. "
09/01/1983 - "One may suggest that some of the clinical features of cirrhosis of the liver, such as testicular atrophy, loss of body hair, night blindness, poor wound healing, poor appetite, susceptibility to infections and enhanced sensitivity to drugs, may be related to conditioned deficiency of zinc, future studies are required to determine whether or not zinc supplementation is beneficial to these patients."

07/23/1983 - "In two of them retinal abnormalities developed, presenting with night blindness and field defects, which improved on withdrawal of the drug."
08/01/2015 - "Fundus albipunctatus (FA) is a rare, congenital form of night blindness with rod system impairment, characterised by the presence of numerous small, white-yellow retinal lesions. "
01/11/2013 - "We previously isolated a dominant mutation, night blindness b (nbb), which causes a late onset of retinal dopaminergic cell degeneration in zebrafish. "
10/01/2012 - "Affected members had night blindness beginning during adolescence with progressive visual acuity and field loss and unmeasurable electroretinographic responses, as well as macular outer retinal loss, although residual cones with increased cone spacing were observed in the youngest individual. "
10/23/2009 - "Loss of Cav1.4 function causes severe impairment of retinal circuitry function and has been linked to night blindness in humans and mice. "

01/01/1982 - "The patient's night blindness improved, but his retinopathy remained unchanged as demonstrated by fluorescein angiography. "

01/01/1996 - "The goal of this study was to describe a family with X-linked congenital stationary night blindness (CSNB) in which 3 brothers had similar symptoms: night blindness, reduced visual acuity and "negative" type of Flash ERG. "
01/01/2014 - "Furthermore, human TRPM1 mutations are associated with congenital stationary night blindness (CSNB), whose patients lack rod function and suffer from night blindness starting in early childhood. "
08/01/2009 - "With congenital stationary night blindness (CSNB), the finding of youngsters who are clearly capable of mobility at night and the fact that the term night blindness refers to a function instead of a disorder forces us even more to reconsider nomenclature."
03/01/2002 - "A 30-year-old male with a history of night blindness, several members of his family, a patient with "complete" congenital stationary night blindness (CSNB1), and groups of age-similar control subjects. "
12/01/1997 - "X-linked congenital stationary night blindness (CSNBX) is a nonprogressive disease causing night blindness and reduced visual acuity. "

02/01/2008 - "Clinical studies of 4-HPR have shown side effects consisting of night blindness and ocular toxicity. "
11/01/2001 - "These results suggest that 4-HBR may have a significant chemotherapeutic advantage over 4-HPR, as the nonhydrolyzable analog may not cause night blindness which occurs as a significant side effect of 4-HPR usage."
10/01/1999 - "The 400 mg dose of fenretinide was associated with symptomatic nyctalopia in one-third of patients making it an unsuitable dose for use in breast cancer prevention studies."
12/01/2011 - "A Night Blindness Questionnaire was used to monitor nyctalopia, which was slightly, but not significantly, more common on fenretinide. "
10/01/2010 - "Our aim was to investigate the relationship between 4-HPR pharmacokinetics, plasma retinol reduction and incidence of nyctalopia. "

11/01/2013 - "Constitutively active rhodopsin mutants causing night blindness are effectively phosphorylated by GRKs but differ in arrestin-1 binding."
06/14/2013 - "The decrease in the thermal stability of dark state rhodopsin is likely to be associated with higher levels of dark noise that undermine the sensitivity of rhodopsin, potentially accounting for night blindness in the early stages of RP. "
01/01/2010 - "1 rhodopsin mutations in congenital night blindness."
11/05/2008 - "The G90D rhodopsin mutation is known to produce congenital night blindness in humans. "
11/05/2008 - "Night blindness and the mechanism of constitutive signaling of mutant G90D rhodopsin."

01/01/2007 - "Oguchi disease, originally described in Japanese people, is a rare form of stationary night blindness in patients with normal acuity. "
01/01/2007 - "[Oguchi disease or stationary congenital night blindness: a case report]."
11/01/2000 - "Patients with some forms of stationary night blindness, such as fundus albipunctatus and Oguchi disease, may develop degeneration of the retina leading to severe loss of vision in later life. "
11/01/2000 - "Molecular genetics of Oguchi disease, fundus albipunctatus, and other forms of stationary night blindness: LVII Edward Jackson Memorial Lecture."
03/17/1998 - "To date, three different mutations in the RK locus have been associated with Oguchi disease, an autosomal recessive form of stationary night blindness in man characterized in part by delayed photoreceptor recovery [Yamamoto, S. "

12/01/2011 - "Self-reported nyctalopia was not a useful indicator of retinol deficiency. "
12/01/2011 - "Positive (PPV) and Negative (NPV) Predictive Values: of nyctalopia for any (PPV 62.9%; NPV 32.8%) and severe (PPV 25.7%; NPV 85.9%) retinol deficiency; of ocular signs for any (PPV 93.3%; NPV 38.2%) and severe (PPV 73.1%; NPV 87.8%) retinol deficiency, and VAD (PPV 86.5%, NPV 38.2%). "
08/01/2014 - "Vitamin A deficiency (VAD) can cause a range of ocular manifestations, including night blindness, conjunctival and corneal xerosis and keratomalacia. "
11/01/1996 - "Clinical signs of xerophthalmia (night blindness, Bitot's spots, corneal xerophthalmia and keratomalacia). "
05/01/2014 - "Xerophthalmia refers to the ocular manifestations associated with vitamin A deficiency, including xerosis, keratomalacia, nyctalopia and Bitot's spot. "

01/02/2013 - "Recently, we demonstrated restoration of vision following rod-photoreceptor transplantation into a mouse model of stationary night-blindness, raising the critical question of whether photoreceptor replacement is equally effective in different types and stages of degeneration. "

07/01/1985 - "A 53-year-old woman developed night blindness 9 years after jejunoileal bypass surgery. "
07/01/1985 - "Night blindness after jejunoileal bypass surgery."
06/01/1980 - "Reversible night blindness associated with intestinal bypass surgery."
01/01/1982 - "Vitamin A deficiency associated with retinopathy and night blindness was observed in a patient 4 yr after jejunoileal bypass. "
06/01/1980 - "A 33-year-old man had a sudden onset of night blindness 3 1/2 years after intestinal bypass surgery for morbid obesity. "

06/01/2012 - "We report two cases of night blindness and visual impairment caused by VAD after malabsorptive bariatric surgery. "
08/01/2006 - "Vitamin A deficiency, often presenting with nyctalopia, has been described in a number of patients with malabsorption as a result of intestinal bypass surgery and, more recently, bariatric surgery. "
06/01/2005 - "To report the ocular complications of xerophthalmia, nyctalopia, and visual deterioration to legal blindness as a result of inadequate vitamin A supplementation after malabsorptive bariatric surgery. "

06/01/2013 - "Deficiencies in vitamins A, D, and E have been linked to night blindness, bone health, and post-liver transplant reperfusion injury. "
08/27/1998 - "We describe a case of night blindness due to vitamin A deficiency resulting from bile duct strictures in a post-orthotopic liver transplant patient and its successful resolution with vitamin A supplementation."

05/01/2012 - "The authors describe a man who presented follicular hyperkeratosis with nyctalopia and xerophthalmia that had appeared 1 year after biliopancreatic diversion. "
01/01/1999 - "Unusual combination of night blindness and optic neuropathy after biliopancreatic bypass."