Cyclic Nucleotides

05/01/1979 - "Bearing in mind the principal possibility of correcting this ratio, further study of the metabolism of cyclic nucleotides in cerebral tumors holds promise for their treatment."
03/01/1994 - "Several studies have shown altered biokinetics of cyclic nucleotides in human cancer. "
03/01/1991 - "[Correlation between urinary cyclic nucleotides in the dynamic study of rats with radiogenic tumors]."
01/01/2014 - "ABCC4/MRP4 is an organic anion transporter that mediates cellular efflux of a wide range of exogenous and endogenous compounds such as cyclic nucleotides and anti-cancer drugs; however, it remains unclear whether ABCC4 and its orthologs function in the detoxification of organochlorine pesticides. "
01/01/2014 - "Taken together, our data show that aromatic ring substituents can add unwanted effects to cyclic nucleotides, and that such nucleotide analogs must be used with care, particularly when working with cells expressing OATP1B1/1B3, like hepatocytes, or intact animals where hepatic metabolism can be an issue, as well as certain cancer cells. "

01/01/1996 - "Radioimmunoassay was used to determine prostaglandin (PGE-2) and cyclic nucleotides (cAMP and cGMP) concentrations in the serum before, 1 and 2 hours after standard test breakfast (5066 kJ) in 65 patients with duodenal ulcer. "
03/01/1987 - "[Hormonal indices and cyclic nucleotides in duodenal ulcer]."
09/01/1995 - "The revealed changes in the levels of prostaglandins and cyclic nucleotides in patients with duodenal ulcer provide an additional index to be used while performing selective proximal vagotomy that results in their normalization."
03/01/1989 - "[Effect of low-energy laser radiation on the levels of cyclic nucleotides and lactic acid of the mucous membranes in gastric and duodenal ulcers]."
03/01/1989 - "The level of cyclic nucleotides in biological material undergoes changes due to endoscopic treatment of gastric and duodenal ulcers with the help of helium-neon laser radiation which, in addition to dynamics of the clinical picture and gastroduodenoscopic data, makes it possible to diagnose the disease remission and in certain cases to predict the course of peptic ulcer."

01/01/1989 - "The changes in the content of cyclic nucleotides in blood plasma and gastric mucosa may play an important role in the realization of positive metabolic changes in gastric mucosa, induced by pyridinolcarbamat and HBO in peptic ulcer patients."
01/01/1987 - "In peptic ulcer the level of cyclic nucleotides in the blood and gastric mucosa was on an increase. "
02/01/1984 - "[Cyclic nucleotides, acid formation and the endoscopic picture in duodenal peptic ulcer patients]."
01/01/1984 - "[Cyclases and cyclic nucleotides in peptic ulcer]."
01/01/1987 - "In patients with chronic atrophic gastritis changes of prostaglandins and cyclic nucleotides as compared to those in patients with peptic ulcer, were contrary."

09/01/1996 - "The aim of this investigation was to evaluate the role played by cyclic nucleotides in the transduction of inflammatory pain and hyperalgesia. "
05/01/2013 - "We report that inhibitors of ATP-binding cassette transporters, of ecto-5'-phosphodiesterase and ecto-5'nucleotidase (enzymes involved in the metabolism of cyclic nucleotides to adenosine) and of A1 adenosine receptors each eliminated the late, but not the early, phase of PGE2 -induced hyperalgesia in primed animals. "

09/01/2008 - "In conclusion, using a rat model of hemiparkinsonism, we observed a significant reduction in the levels of cyclic nucleotides in both hemispheres at the peak of levodopa-induced dyskinesias. "
09/01/2008 - "Pretreatment with zaprinast reduced the severity of levodopa-induced dyskinesias, and partly prevented the decrease in cyclic nucleotides compared with pretreatment with saline-levodopa. "