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Nortriptyline (Aventyl)

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A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.

Also Known As:

Aventyl; Pamelor; Nortriptyline Hydrochloride; Allegron; Apo-Nortriptyline; Apotex Brand of Nortriptyline Hydrochloride; Dista Brand of Nortriptyline Hydrochloride; Gen-Nortriptyline; Genpharm Brand of Nortriptyline Hydrochloride; Lilly Brand of Nortriptyline Hydrochloride; Lundbeck Brand of Nortriptyline Hydrochloride; Mallinckrodt Brand of Nortriptyline Hydrochloride; Norfenazin; Nortrilen; Novo-Nortriptyline; Novopharm Brand of Nortriptyline Hydrochloride; Nu-Nortriptyline; Nu-Pharm Brand of Nortriptyline Hydrochloride; PMS-Nortriptyline; Paxtibi; Pharmascience Brand of Nortriptyline Hydrochloride; Ratiopharm Brand of Nortriptyline Hydrochloride; Reig Jofre Brand of Nortriptyline Hydrochloride; ratio-Nortriptyline; Apo Nortriptyline; Gen Nortriptyline; Hydrochloride, Nortriptyline; Novo Nortriptyline; Nu Nortriptyline; Nu Pharm Brand of Nortriptyline Hydrochloride; PMS Nortriptyline; ratio Nortriptyline; Desitriptyline; Desmethylamitriptylin; 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N-methyl-

Networked: 363 relevant articles (49 outcomes, 85 trials/studies)

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Drug Context: Research Results

Experts

1.	McGuffin, Peter: 13 articles (12/2014 - 01/2009)
2.	Uher, Rudolf: 13 articles (12/2014 - 01/2009)
3.	Mors, Ole: 11 articles (12/2014 - 01/2009)
4.	Maier, Wolfgang: 11 articles (12/2014 - 01/2009)
5.	Henigsberg, Neven: 11 articles (12/2014 - 01/2009)
6.	Hauser, Joanna: 9 articles (12/2014 - 01/2009)
7.	Aitchison, Katherine J: 9 articles (02/2013 - 01/2009)
8.	Placentino, Anna: 9 articles (12/2012 - 01/2009)
9.	Souery, Daniel: 8 articles (12/2014 - 01/2009)
10.	Farmer, Anne: 8 articles (12/2014 - 03/2009)

Related Diseases

1.	Pain (Aches) 06/01/1998 - "Reduction in pain intensity scores was significantly greater for participants randomized to nortriptyline (difference in mean change 1.68, 95%-0.001, CI -3.36, P = 0.050), with a reduction of pain by 22% compared to 9% on placebo. " 05/01/2010 - "Although nortriptyline was effective for her pain, it could bring about fatal cardiac adverse events. " 12/01/2011 - "One patient had further cryoanalgesia, one was referred for specialist pain management, and one controlled the pain with nortriptyline. " 05/01/2009 - "Correspondingly in the 30 people treated with nortriptyline, the mean (SD) intensity of pain and/or sensory complaints decreased from 4.9 (1.9) to 3.3 (2.1) (P < 0.001). " 11/01/1999 - "Nortriptyline had no effect on the pain scores. "
2.	Stroke (Strokes) 02/11/1984 - "Post-stroke depressions are common, severe, and longstanding, and the demonstrated efficacy of nortriptyline provides an important addition to the treatments available for stroke patients." 02/11/1984 - "The efficacy of nortriptyline in the treatment of post-stroke depression was assessed by a double-blind study in thirty-four patients. " 05/01/2003 - "There were no significant differences between the nortriptyline and placebo groups in demographic characteristics, stroke type, and neurological findings. " 04/07/1984 - "Nortriptyline for post-stroke depression." 03/03/1984 - "Side-effects of nortriptyline treatment for post-stroke depression."
3.	Major Depressive Disorder (Major Depressive Disorders) 04/01/2014 - "In the present study, we used PET and (S,S)-[18¹⁸F]FMeNER-D₂ to investigate NET occupancies in the thalamus in 10 patients with major depressive disorder taking various doses of nortriptyline, who were considered to be responders to the treatment. " 07/01/1992 - "Data are presented on the baseline characteristics and 2- to 3-year follow-up assessments of placebo-washout responders (PWRs) from a previously reported pharmacokinetically designed double-blind placebo-controlled trial of nortriptyline for major depressive disorder in 6- to 12-year-olds. " 01/01/1992 - "A random assignment, double-blind, placebo-controlled study of nortriptyline in 50 prepubertal 6- to 12-year-olds with Research Diagnostic Criteria and DSM-III major depressive disorder was performed. " 01/01/1992 - "Pharmacokinetically designed double-blind placebo-controlled study of nortriptyline in 6- to 12-year-olds with major depressive disorder." 01/01/1990 - "We performed a random assignment, double-blind, placebo-controlled study of nortriptyline (NT) in postpubertal 12- to 17-year-olds with Research Diagnostic Criteria (RDC) and DSM-III major depressive disorder. "
4.	Neuralgia (Stump Neuralgia) 01/01/2015 - "We found little evidence to support the use of nortriptyline to treat the neuropathic pain conditions included in this review. " 01/01/2015 - "We included randomised, double-blind studies of at least two weeks' duration comparing nortriptyline with placebo or another active treatment in chronic neuropathic pain. " 01/01/2015 - "To assess the analgesic efficacy and associated adverse events of nortriptyline for chronic neuropathic pain in adults. " 01/01/2015 - "Nortriptyline for neuropathic pain in adults." 08/01/2010 - "MORs are thus not critical for nortriptyline action against neuropathic pain. "
5.	Tinnitus 01/01/1992 - "Preliminary analysis of global outcome on the first 52 patients reveals that those receiving nortriptyline were more likely to feel that their drug had been helpful (74% vs. 36%, p less than 0.01), but were equally likely to report that their tinnitus was improved (37% vs. 32%, NS). " 11/01/1989 - "To explore further this link between tinnitus and depression, and to investigate the efficacy of treating depression in the treatment of tinnitus, a single-blind, placebo-washout, nonrandomized pilot study of the tricyclic antidepressant nortriptyline (hydrochloride) was undertaken in disabled tinnitus patients who also met diagnostic criteria for major depression. " 10/11/1993 - "To determine whether the antidepressant, nortriptyline, is effective for treatment of depression, tinnitus-related disability, and tinnitus symptoms in patients with severe chronic tinnitus. " 11/01/1989 - "Fourteen considered their tinnitus improved, and 12 chose to continue taking nortriptyline after the study. " 10/11/1993 - "A randomized trial of nortriptyline for severe chronic tinnitus. "

Related Drugs and Biologics

1.	Amitriptyline (Elavil)
2.	Fluoxetine (Prozac)
3.	Citalopram (Escitalopram)
4.	Desipramine (Pertofrane)
5.	Bupropion (Wellbutrin)
6.	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)
7.	Sertraline (Zoloft)
8.	gabapentin (Neurontin)
9.	Antidepressive Agents (Antidepressants)
10.	Morphine (MS Contin)

Related Therapies and Procedures

1.	Vasectomy (Vas Occlusion)
2.	Transcutaneous Electric Nerve Stimulation (TENS)
3.	Aftercare (After-Treatment)
4.	Intraventricular Injections
5.	Drug Therapy (Chemotherapy)