Octopamine

An alpha-adrenergic sympathomimetic amine, biosynthesized from tyramine in the CNS and platelets and also in invertebrate nervous systems. It is used to treat hypotension and as a cardiotonic. The natural D(-) form is more potent than the L(+) form in producing cardiovascular adrenergic responses. It is also a neurotransmitter in some invertebrates.

Also Known As:

Networked: 133 relevant articles (0 outcomes, 9 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	D'Andrea, G: 6 articles (05/2015 - 05/2003)
2.	D'Andrea, Giovanni: 4 articles (08/2013 - 05/2008)
3.	Leon, A: 3 articles (05/2015 - 05/2003)
4.	Bolner, Andrea: 3 articles (08/2013 - 05/2008)
5.	Colavito, Davide: 3 articles (08/2013 - 05/2008)
6.	Leon, Alberta: 3 articles (08/2013 - 01/2010)
7.	Perini, F: 3 articles (05/2007 - 05/2004)
8.	Terrazzino, S: 3 articles (10/2004 - 05/2003)
9.	Sehgal, Amita: 2 articles (01/2015 - 09/2012)
10.	Pflüger, Hans-Joachim: 2 articles (01/2009 - 01/2008)

Related Diseases

1.	Weight Loss (Weight Reduction) 01/01/2015 - "No human studies have examined the effects of p-octopamine on athletic performance or weight loss and weight management. " 01/01/2013 - "All these effects are compatible with an overall stimulating effect of octopamine on metabolism, which is compatible with its reported weight-loss effects in experimental animals." 01/01/2013 - "Weight-loss and adrenergic actions are always related to metabolic changes and this work was designed to investigate a possible action of octopamine on liver metabolism. " 01/01/2015 - "p-Octopamine modestly binds to β-3 adrenergic receptors and may therefore promote lipolysis and weight loss. " 09/01/2005 - "Ephedra-free weight loss dietary supplements containing bitter orange (Citrus aurantium), a botanical source of the adrenergic amines synephrine and octopamine, have quickly emerged on consumer markets to replace banned ephedra products. "
2.	Ganglion Cysts (Ganglion) 11/01/2014 - "Octopamine-like immunoreactive neurons in the brain and subesophageal ganglion of the parasitic wasps Nasonia vitripennis and N. " 05/01/2014 - "Physiological and anatomical experiments identify Gr32a to octopamine neuron synaptic and functional connections in the suboesophageal ganglion. " 01/01/2014 - "We have previously shown that octopamine neurons in the abdominal ganglion innervate the oviduct epithelium. " 06/15/2010 - "Here we map the segmental location and developmental origins of individual octopamine neurons in the Drosophila subesophageal ganglion. " 06/15/2010 - "The median octopamine cluster of the subesophageal ganglion consists of defined sets of paired and unpaired interneurons, which supply the brain and subesophageal ganglion with extensive ramifications. "
3.	Migraine Disorders (Migraine) 05/25/2004 - "In migraine patients, plasma levels of octopamine and synephrine were higher compared with controls, although in migraine with aura, the difference was not significant. " 10/01/2004 - "In addition, the high levels of circulating tyramine, octopamine and synephrine (elusive amines), recently reported in both migraine types and CH, are discussed in relation to the other "classic" amines findings. " 10/01/2004 - "Nonetheless the association of CH and migraine to a new class of amine, namely trace or elusive amines such as tyramine, octopamine and synephrine, has recently been demonstrated. " 05/01/2003 - "Although the role of trace amines such as tyramine, octopamine and synephrine in the pathogenesis of migraine has been debated for decades, this issue remains still unresolved. " 05/01/2007 - "Recent studies have suggested that abnormalities of dopamine and trace amines (tyramine, octopamine, and synephrine), products of tyrosine metabolism, may constitute the metabolic events that predispose to the occurrence of cluster headache (CH) and migraine attacks. "
4.	Fibrosis (Cirrhosis) 01/01/1983 - "It is suggested that octopamine may play a role in the pathogenesis of the cardiorespiratory hemodynamic impairment of cirrhosis and sepsis where high levels of this false neurotransmitter were observed." 12/01/1988 - "Saline expansion (7% body weight), acute biliary obstruction, chronic cirrhosis with ascites, and chronic thoracic caval constriction with the production of ascites all abolish the effect of octopamine when administered at 100 micrograms/min. Though octopamine may directly influence renal perfusion, its possible role in liver disease remains uncertain." 07/01/1980 - "The aim of this study was to evaluate brain tissue levels of dopamine, noradrenaline, and octopamine in patients with cirrhosis and HE. " 07/01/1980 - "Our results showed that (1) dopamine and noradrenaline levels are identical in cirrhotic patients with or without HE and in patients without liver disease (P < 0.05); (2) octopamine levels are higher in control subjects than in patients with cirrhosis and HE. "
5.	Shock 01/07/2014 - "We found that both octopamine and 20-hydroxyecdisone are dispensable for shock responsiveness while dopamine and serotonin act as down-regulators of sting responsiveness. " 09/01/2005 - "Previous studies in honey bees and fruit-flies Drosophila suggested that octopamine (OA, invertebrate counterpart of noradrenaline) and dopamine (DA) participate in appetitive olfactory conditioning with sucrose reward and aversive olfactory conditioning with electric shock punishment, respectively. "

Related Drugs and Biologics

1.	Dopamine (Intropin)
2.	Tyramine
3.	Norepinephrine (Noradrenaline)
4.	Synephrine (Oxedrine)
5.	Serotonin (5 Hydroxytryptamine)
6.	Amines
7.	Tyrosine (L-Tyrosine)
8.	Caffeine (No Doz)
9.	Sucrose (Saccharose)
10.	Transcription Factor AP-2

Related Therapies and Procedures

1.	Electrodes (Electrode)
2.	Trabeculectomy (Trabeculoplasty)
3.	Injections