Norfloxacin

A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.

Also Known As:

Networked: 897 relevant articles (139 outcomes, 169 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Francés, Rubén: 11 articles (01/2020 - 09/2006)
2.	Zapater, Pedro: 11 articles (01/2020 - 09/2006)
3.	Such, José: 10 articles (01/2018 - 09/2006)
4.	González-Navajas, José M: 8 articles (01/2020 - 09/2006)
5.	Gómez-Hurtado, Isabel: 6 articles (01/2020 - 03/2011)
6.	Fernández, Javier: 6 articles (05/2012 - 01/2002)
7.	Bellot, Pablo: 5 articles (01/2018 - 03/2008)
8.	Navasa, Miquel: 5 articles (03/2012 - 01/2002)
9.	Pascual, Sonia: 5 articles (03/2011 - 09/2006)
10.	Pérez-Mateo, Miguel: 5 articles (03/2011 - 09/2006)

Related Diseases

1.	Infections 01/01/1988 - "In 12 recent clinical studies, norfloxacin given in various dosage regimens was shown to be highly effective in treating 1,588 gonococcal infections in 1,486 patients. " 01/01/1986 - "Norfloxacin has a well proven efficacy in UTI but remains to be proven in enteric infections." 06/01/1983 - "Clinical results were excellent in both groups; norfloxacin was effective in infections due to Ps. " 01/01/1986 - "Preliminary data from ongoing trials have also shown that norfloxacin is effective in the prophylaxis of traveller's diarrhoea and infections in the granulocytopenic patient. " 01/01/1984 - "In this study norfloxacin was particularly effective in treatment of P aeruginosa infection of the rabbit cornea, and caused no toxicity in normal rabbit eyes after prolonged administration. "
2.	Urinary Tract Infections (Urinary Tract Infection) 01/01/1990 - "Norfloxacin was also highly effective in the treatment of multiply resistant, nosocomial urinary tract infections (UTIs), in which Pseudomonas aeruginosa and E. " 04/01/1998 - "Norfloxacin 400 mg twice-a-day has proven to be effective and safe in the treatment of uncomplicated urinary tract infections (UTI). " 01/01/1988 - "The therapeutic efficacy and safety of norfloxacin 400 mg twice daily for 3 or 7 days was compared in a double-blind randomized multiclinic study including 485 female general practice patients with uncomplicated symptomatic lower urinary tract infections. " 04/01/1998 - "In this study, norfloxacin 800 mg once-a-day was as effective and safe as norfloxacin 400 mg twice-a-day in the treatment of uncomplicated urinary tract infections in women." 09/01/1985 - "Norfloxacin is an antibacterial drug chiefly eliminated by the kidney and therefore useful in the treatment of urinary tract infections. "
3.	Bacterial Infections (Bacterial Infection) 06/15/1992 - "Norfloxacin appears to be an effective and relatively safe agent for the treatment of bacterial infections of the eyelids or conjunctiva, or both. " 01/01/1992 - "Norfloxacin appears to be an effective and relatively safe agent for the treatment of bacterial infections of the lids and/or conjunctiva. " 05/01/1992 - "The aim of the study has been to assess if intermittent treatment with norfloxacin could be able to maintain selective intestinal decontamination in cirrhotic patients in order to prevent bacterial infections. " 04/01/2023 - "The use of norfloxacin prophylaxis at the time of the diagnosis of bacterial infections was not associated with multidrug resistance. " 04/01/2023 - "Among the 472 patients from 28 centers, 53 (11%) were receiving norfloxacin at the time of the bacterial infection. "
4.	Peritonitis 04/01/2021 - "Continuous long-term selective intestinal decontamination with norfloxacin is the most widely used prophylactic strategy in spontaneous bacterial peritonitis, yet other equally effective and safe options are available." 03/01/1997 - "Continuous long-term selective intestinal decontamination with norfloxacin is effective in preventing the first spontaneous bacterial peritonitis in cirrhotic patients at high risk. " 06/01/2002 - "Norfloxacin was more effective in the prevention of peritonitis recurrence due to Enterobacteriaceae (0% vs 22%, P = .01). " 01/01/2020 - "Efficacy of Norfloxacin Prophylaxis to Prevent Spontaneous Bacterial Peritonitis: A Systematic Review and Meta-Analysis." 01/01/1997 - "The study was performed to compare the spontaneous bacterial peritonitis occurring in patients with and without prophylactic norfloxacin. "
5.	Diarrhea 12/01/1998 - "On this trek she had developed diarrhea which had been cured with norfloxacin 400 mg two times per day for 3 days. " 08/01/2020 - "In this study, fifty-four weaned piglets with diarrhea were selected and treated with saline (control), C-BF or norfloxacin nicotinic (NFN) for 7 days. " 10/01/1993 - "Short-term treatment of traveler's diarrhea with norfloxacin: a double-blind, placebo-controlled study during two seasons." 05/01/1986 - "Four (7%) of 54 subjects receiving norfloxacin (400 mg daily) experienced diarrhea during a two-week study; in contrast, 34 (60%) of 57 placebo recipients developed diarrhea (P less than .0001). " 01/01/2020 - "He admitted to having taken norfloxacin 400 mg twice daily for 3 days for diarrhea, 5 days prior to the onset of the lesions. "

Related Drugs and Biologics

1.	Ciprofloxacin (Cipro)
2.	Sulfamethoxazole Drug Combination Trimethoprim (Co-Trimoxazole)
3.	Ofloxacin (Ofloxacine)
4.	Anti-Bacterial Agents (Antibiotics)
5.	Fluoroquinolones
6.	lomefloxacin (Maxaquin)
7.	Quinolones
8.	Pefloxacin
9.	Ceftriaxone (Ceftriaxon)
10.	Chloramphenicol (Chloromycetin)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Secondary Prevention
4.	Catheters
5.	Oral Administration