Nonsuppressible Insulin-Like Activity

A blood protein (NSILA) which mimics the biological activity of insulin in serum, but is not suppressed by insulin antibodies. During acid-ethanol extraction of Cohn fraction III, 10% of the activity is found in the supernatant (NSILA-S) and the remaining activity in the precipitate (NSILA-P). The latter is a large molecular compound, much less stable than the soluble fraction. NSILA-S is a more potent growth factor than insulin and exhibits sulfation activity.

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Networked: 23 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Birth Weight (Birth Weights) 08/01/1981 - "The NSILA-S levels in diabetic pregnancies were not different from those in non-diabetic pregnancies and there were no significant correlations between NSILA-S and birth weight, maternal diabetic control, age or duration of diabetes or the treatment required. " 03/01/1979 - "Serum NSILA in 56 term and premature newborns exhibited a significant positive correlation both with gestational age and birth weight but not with serum GH or cortisol levels. " 12/01/1987 - "Our study showed that (1) growth hormone levels were elevated in premature infants and correlated with Apgar scores and birth weights; (2) somatomedin C and nonsuppressible insulin-like activity levels were significantly lower in premature than in term infants; and (3) the birth weight of all infants studied had a significant overall effect on both somatomedin C and nonsuppressible insulin-like activity levels, suggesting that these factors may be involved in fetal growth. " 12/01/1990 - "We measured insulin-like growth factor II and nonsuppressible insulin-like activity levels in the sera of newborn infants with different birth weights and gestational ages to determine the significance of these peptides in fetal growth. " 12/01/1987 - "Growth hormone, somatomedin C, and nonsuppressible insulin-like activity levels compared in premature, small, average birth weight, and large infants."
2.	beta-Thalassemia (Cooley's Anemia) 03/01/1981 - "Studies on the possible mechanism for deficiency of nonsuppressible insulin-like activity in thalassemia major." 10/01/1981 - "The impaired production of NSILA-S in thalassemia major thus appears to be due to hGH insensitivity and not to a biologically inactive endogenous hGH molecule. " 10/01/1981 - "Lack of response of nonsuppressible insulin-like activity to short term administration of human growth hormone in thalassemia major." 10/01/1981 - "We have recently demonstrated that nonsuppressible insulin-like activity (NSILA-S) is very low or undetectable in beta-thalassemia major. " 03/01/1981 - "Previous studies have shown that serum levels of the somatomedin, nonsuppressible insulin-like activity (NSILA-S), are extremely low in patients with thalassemia major. "
3.	Gestational Diabetes (Gestational Diabetes Mellitus) 10/15/1985 - "Nonsuppressible insulin-like activity and somatomedin C levels in normal pregnant women, in pregnant women with gestational diabetes, and in umbilical cord blood of mature and premature infants." 10/15/1985 - "This study was undertaken to determine the significance of the changes in nonsuppressible insulin-like activity as measured by the fat pad assay and by the levels of immunoreactive somatomedin C, growth hormone, and human placental lactogen in sera of term normal pregnant women, mothers who delivered prematurely, and women with gestational diabetes at term as compared to normal nonpregnant subjects. " 10/15/1985 - "Our investigations showed that (1) nonsuppressible insulin-like activity is elevated during pregnancy, but its level was lower in mothers with gestational diabetes in spite of significantly higher serum human placental lactogen compared with normal pregnant mothers; (2) nonsuppressible insulin-like activity is significantly lower in premature infants than in term infants; (3) somatomedin C levels were significantly elevated in pregnant mothers in spite of suppression of growth hormone; (4) nonsuppressible insulin-like activity and somatomedin C levels in infants of mothers with gestational diabetes were not significantly elevated in spite of higher birth weight, indicating that nonsuppressible insulin-like activity and somatomedins are not the only factors responsible for the increase of birth weight of children of diabetic mothers; (5) there was marked discordance between the growth hormone level in the neonates and somatomedin C levels."
4.	Neoplasms (Cancer) 06/01/1978 - "Tumor associated hypoglycemia and elevated serum nonsuppressible insulin-like activity." 09/01/1975 - "Total plasma NSILA-s levels, which are elevated in some patients with extrapancreatic tumors and hypoglycemia, were also found to be elevated in pregnancy. " 05/01/1974 - "Hypoglycemia in association with extrapancreatic tumors: demonstration of elevated plasma NSILA-s by a new radioreceptor assay." 09/01/1975 - "We show that in normal adults the insulin-like bioactivity in plasma due to free NSILA-s in the basal state is equal to that exerted by insulin itself, and that the free NSILA-s in the circulation of patients with extra-pancreatic tumors approximates the elevated level of insulin in patients with insulin-secreting pancreatic tumors." 06/01/1977 - "Adrenocortical carcinoma and hypoglycemia: evidence for production of nonsuppressible insulin-like activity by the tumor."
5.	Hypoglycemia (Reactive Hypoglycemia) 06/01/1978 - "Tumor associated hypoglycemia and elevated serum nonsuppressible insulin-like activity." 09/01/1975 - "Total plasma NSILA-s levels, which are elevated in some patients with extrapancreatic tumors and hypoglycemia, were also found to be elevated in pregnancy. " 05/01/1974 - "Hypoglycemia in association with extrapancreatic tumors: demonstration of elevated plasma NSILA-s by a new radioreceptor assay." 06/01/1977 - "Adrenocortical carcinoma and hypoglycemia: evidence for production of nonsuppressible insulin-like activity by the tumor." 05/01/1978 - "Although further identification by chromatographic extraction was not performed, the substance secreted by the tumor is probably identical to the non-suppressible insulin-like activity (NSILA) isolated by Froesch and responsible for hypoglycemia in a few cases of extrapancreatic tumors. "

Related Drugs and Biologics

1.	Nonsuppressible Insulin-Like Activity
2.	Growth Hormone (Somatotropin)
3.	Insulin-Like Growth Factor I (IGF-1)
4.	Somatomedins (Somatomedin)
5.	Placental Lactogen (Human Placental Lactogen)
6.	Insulin (Novolin)
7.	Glucose (Dextrose)
8.	Ethanol (Ethyl Alcohol)
9.	Acids
10.	Peptides (Polypeptides)

Related Therapies and Procedures

1.	Hypophysectomy