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Nonachlazine
Coronary vasodilator with a novel mechanism of action; proposed as antianginal agent.
Also Known As:
Nonachlazin; Nonakhlazin; Azaclorzine; 10H-Phenothiazine, 2-chloro-10-(3-(hexahydropyrrolo(1,2-a)pyrazin-2(1H)-yl)-1-oxopropyl)-, dihydrochloride
Networked:
24
relevant articles (
3
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Sulfur Compounds: 278
Phenothiazines: 506
Nonachlazine: 24
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
3-Ring Heterocyclic Compounds
Phenothiazines: 506
Nonachlazine: 24
Related Diseases
1.
Myocardial Ischemia (Ischemic Heart Diseases)
03/01/1975 - "
Data on pharmacology of nonachlazine-a new antianginal preparation effective in the treatment of patients with ischemic heart disease-are presented.
"
07/01/1980 - "
The efficacy of nonachlazine given in a daily dose of 90--180 mg was studied in 82 out-patients with ischemic heart disease.
"
11/01/1986 - "
[Mechanisms of the hemodynamic effects of nonachlazine in ischemic heart disease patients].
"
01/01/1983 - "
The activity of a new antianginal drug, nonachlazine, synthetized in the Institute of Pharmacology, Academy of Medical Sciences of the USSR, has been demonstrated using model myocardial ischemias on anesthetized dogs and conscious cats.
"
07/01/1980 - "
[Effectiveness of nonachlazine in ischemic heart disease under ambulatory conditions].
"
2.
Myocardial Infarction
01/01/1990 - "
[Use of nonachlazine in the acute period of myocardial infarction].
"
05/01/1984 - "
[Effect of nonachlazine on the size of an experimental myocardial infarct].
"
09/01/1982 - "
Experiments on 107 rabbits and 76 white rats with the use of electrophysiological, biochemical and electron microscopy research methods have shown that nonachlazine-induced improvement of heart contractility in microfocal myocardial infarction occurs as a result of the shortening of the systolic and lengthening of the diastolic phases of the heart cycle.
"
09/01/1982 - "
[Effect of nonachlazine on the energy provision for cardiac contractile activity in experimental myocardial infarct].
"
09/01/1982 - "
Nonachlazine improves the processes of oxidative phosphorylation in heart mitochondria in myocardial infarction, which is accompanied by inhibition of the activity of succinate dehydrogenase and transition of oxidation from succinate to NAD-dependent substrates.
"
3.
Disease Progression
02/01/1990 - "
Analysis of the effect of anaprilin and nonachlazin on the clinical course and hemodynamics revealed that in patients with initial coronary atherosclerosis of middle age beta-adrenodependent vasodilation of the coronary arteries decreased.
"
01/01/1991 - "
The influence of anaprilin, oxprenolol, nonachlazine, prazosin and levodopa on the clinical course and haemodynamics was investigated in 138 patients with ischaemic heart disease in whom selective coronary angiography had revealed an up to 50 percent stenosis of one of coronary arteries.
"
4.
Ischemia
07/01/1982 - "
Experiments on dogs with acute coronary insufficiency were made to show that nonachlazine in doses of 3 and 5 mg/kg considerably reduces or even prevents the rise of S-T segment on the epicardial electrogram depending on the intensity of ischemia.
"
03/01/1976 - "
This mechanism could underlie the block by nonachlazine of the pain syndrome during the heart ischemia disease.
"
07/01/1982 - "
Nonachlazine prevents an increase in the content of lactate and in the lactate/pyruvate ratio in the blood outflowing from the focus of ischemia.
"
5.
Infarction (Infarctions)
01/01/1980 - "
[Effect of nonachlazine on the echocardiographic parameters in patients with post-infarct cardiosclerosis].
"
05/01/1984 - "
The effect of intravenous injection of nonachlazine on the infarction size in rabbits was studied planimetrically 7 days after coronary artery occlusion.
"
Related Drugs and Biologics
1.
Adrenergic Agents (Adrenergic Drugs)
2.
Lactic Acid (Lactate)
3.
Moricizine (Moracizine)
4.
Propranolol (Inderal)
5.
NAD (NADH)
6.
Adenosine Triphosphate (ATP)
7.
Succinic Acid (Succinate)
8.
Pyruvic Acid (Pyruvate)
9.
Vasoconstrictor Agents
10.
Succinate Dehydrogenase (Fumarate Reductase)
Related Therapies and Procedures
1.
Therapeutics
2.
Ligation
3.
Intravenous Injections
4.
Intraperitoneal Injections