Nogalamycin

An anthrocycline from a Streptomyces nogalater variant. It is a cytolytic antineoplastic that inhibits DNA-dependent RNA synthesis by binding to DNA.

Also Known As:

U-15167; U 15167; U15167; 2,6-Epoxy-2H-naphthaceno(1,2-b)oxocin-14-carboxylic acid, 11-((6-deoxy-3-C-methyl-2,3,4-tri-O-methyl-alpha-L-mannopyranosyl)oxy)-4-(dimethylamino)-3,4,5,6,9,11,12,13,14,16-decahydro-3,5,8,10,13-pentahydroxy-6,13-dimethyl-9,16-dioxo-, methyl ester, (2R-(2alpha,3beta,4alpha,5beta,6alpha,11beta,13alpha,14alpha))-

Networked: 19 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Metsä-Ketelä, Mikko: 1 article (11/2020)
2.	Nji Wandi, Benjamin: 1 article (11/2020)
3.	Palmu, Kaisa: 1 article (11/2020)
4.	Siitonen, Vilja: 1 article (11/2020)
5.	Alam, Neyaz: 1 article (03/2019)
6.	Dasgupta, Hemantika: 1 article (03/2019)
7.	Islam, Md Saimul: 1 article (03/2019)
8.	Panda, Chinmay Kumar: 1 article (03/2019)
9.	Roy, Anup: 1 article (03/2019)
10.	Roychoudhury, Susanta: 1 article (03/2019)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/1991 - "Among nogalamycin derivatives, menogaril showed distinct biochemical effects as well as superior cytotoxicity and antitumor activity and also proved to be effective against breast cancer clinically." 12/06/2018 - "Nogalamycin monoxygenase (NMO) is a member of a family of enzymes that catalyze a key step in the biosynthesis of tetracycline antibiotics used to treat, for example, breast cancer in humans, using molecular oxygen for substrate oxidation but without an apparent cofactor. " 11/01/1992 - "The therapeutic effects of orally administered menogaril, a semisynthetic analog of the anthracycline antibiotic nogalamycin, were studied on a panel of human stomach and breast cancer xenografts. "
2.	Neoplasms (Cancer) 07/01/1976 - "Chemically induced fibrosarcoma tumors and tumors of spontaneous origin in rats were successfully regressed following the administration of nogalamycin. " 07/01/1976 - "Cytological effect of nogalamycin in mammals and regression of methylcholanthrene-induced and spontaneous tumors in rats." 07/01/1976 - "Simultaneous transplantation of chemically induced fibrosarcoma tumors and intraperitoneal administration of nogalamycin, irreversibly inhibited growth of primary tumors in rats. " 07/01/1976 - "The most effective concentration of nogalamycin for either regression of actively growing fibrosarcoma tumors or inhibition of transplanted fibrosarcoma cells was 556 mug/kg of body weight." 11/02/2020 - "Nogalamycin is an anthracycline anti-cancer agent that intercalates into the DNA double helix. "
3.	Cardiotoxicity 10/01/1989 - "Menogaril, an anthracycline analog of nogalamycin, is reported to have greater cytotoxicity against certain malignant cell lines and less cardiotoxicity in rabbits than doxorubicin. " 01/01/1987 - "Menogaril (7-con-O-methylnogarol) is a semisynthetic anthracycline analogue of nogalamycin that has shown good activity against a variety of experimental tumor systems as well as decreased cardiac toxicity when compared with doxorubicin in preclinical studies. "
4.	Leukemia 11/01/1993 - "Fifteen patients with relapsed or refractory acute leukemia were treated in this phase I study of menogaril (7-con-O-methylnogarol), a nogalamycin anthracycline derivative. " 11/01/1979 - "The chemotherapeutic activity of analogs of the anthracycline antibiotic, nogalamycin, was investigated in the P388 and L1210 leukemias and the B16 melanoma in mice. "
5.	Experimental Melanoma 01/01/1981 - "We compare here the lethality of several nogalamycin analogs against Chinese hamster ovary (CHO), mouse leukemia (L1210), and mouse melanoma (B16) cells in culture. " 01/01/1981 - "Cell kill kinetics of several nogalamycin analogs and adriamycin for Chinese hamster ovary, L1210 leukemia, and B16 melanoma cells in culture." 11/01/1979 - "The chemotherapeutic activity of analogs of the anthracycline antibiotic, nogalamycin, was investigated in the P388 and L1210 leukemias and the B16 melanoma in mice. "

Related Drugs and Biologics

1.	Menogaril
2.	Anthracyclines
3.	Doxorubicin (Adriamycin)
4.	Anti-Bacterial Agents (Antibiotics)
5.	DNA (Deoxyribonucleic Acid)
6.	Daunorubicin (Cerubidine)
7.	Therapeutic Uses
8.	Mitomycin (Mitomycin-C)
9.	Aclarubicin
10.	Tubercidin

Related Therapies and Procedures

1.	Transplantation
2.	Aftercare (After-Treatment)