Nicotinamide-Nucleotide Adenylyltransferase

An enzyme that catalyzes reversibly the transfer of the adenylyl moiety of ATP to the phosphoryl group of NMN to form NAD+ and pyrophosphate. The enzyme is found predominantly in the nuclei and catalyzes the final reaction in the major pathway for the biosynthesis of NAD in mammals.

Also Known As:

ATP-NMN Adenylyltransferase; ATP NMN Adenylyltransferase; Adenylyltransferase, ATP-NMN; Adenylyltransferase, NMN; Adenylyltransferase, Nicotinamide Mononucleotide; Adenylyltransferase, Nicotinamide-Nucleotide; Mononucleotide Adenylyltransferase, Nicotinamide; Nicotinamide Nucleotide Adenylyltransferase; Pyrophosphorylase, NAD; NAD Pyrophosphorylase; NMN Adenylyltransferase; Nicotinamide Mononucleotide Adenylyltransferase; ATP:nicotinamide-nucleotide adenylyltransferase

Networked: 42 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zhai, R Grace: 6 articles (12/2021 - 11/2006)
2.	Zhu, Yi: 4 articles (12/2021 - 09/2019)
3.	Liang, Jia: 3 articles (08/2022 - 06/2015)
4.	Wang, Peng: 3 articles (08/2022 - 06/2015)
5.	Li, Chong: 3 articles (12/2021 - 09/2019)
6.	Liu, Jiaqi: 3 articles (12/2021 - 10/2019)
7.	Ren, Lili: 2 articles (08/2022 - 11/2019)
8.	Tao, Xianzun: 2 articles (12/2021 - 09/2019)
9.	Brown, Emily E: 2 articles (01/2021 - 09/2020)
10.	Farmer, Raymond: 2 articles (01/2021 - 09/2020)

Related Diseases

1.	Brain Injuries (Brain Injury) 02/25/2016 - "Gain-of-function mutations in the mouse nicotinamide mononucleotide adenylyltransferase type 1 (Nmnat1) produce two remarkable phenotypes: protection against traumatic axonal degeneration and reduced hypoxic brain injury. "
2.	Wallerian Degeneration 05/13/2009 - "Nicotinamide mononucleotide adenylyltransferase expression in mitochondrial matrix delays Wallerian degeneration." 04/01/2003 - "We cross-bred these mice with the spontaneous mutant C57BL/Wld(s) typically showing protection from Wallerian degeneration because of fusion of the ubiquitination factor E4B (Ube4b) and nicotinamide mononucleotide adenylyltransferase (Nmnat) genes. " 12/01/2001 - "We identified the protective gene, which encodes an N-terminal fragment of ubiquitination factor E4B (Ube4b) fused to nicotinamide mononucleotide adenylyltransferase (Nmnat), and showed that it confers a dose-dependent block of Wallerian degeneration. " 02/28/2022 - "In this report, we analyze the various signaling domains of SARM1, the recent findings on Wallerian degeneration and its relation to axonal insults, as well as its connection to SARM1, the mitogen-activated protein kinase (MAPK) signaling, and the survival factor, nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2). " 01/01/2019 - "Nicotinamide mononucleotide adenylyltransferase (NMNAT), a key enzyme for NAD⁺ synthesis, is well known for its activity in neuronal survival and attenuation of Wallerian degeneration. "
3.	Hemolytic Anemia 05/23/2014 - "Deficiency of nicotinamide mononucleotide adenylyltransferase 3 (nmnat3) causes hemolytic anemia by altering the glycolytic flow in mature erythrocytes." 12/31/2022 - "In a previous study, we had demonstrated that the deficiency of nicotinamide mononucleotide adenylyltransferase 3 (Nmnat3), an enzyme catalyzing NAD+ synthesis, causes hemolytic anemia accompanied by a drastic decline in the NAD+ levels in the erythrocytes. "
4.	Ischemic Stroke 06/01/2015 - "Nicotinamide Mononucleotide Adenylyltransferase 1 Protects Neural Cells Against Ischemic Injury in Primary Cultured Neuronal Cells and Mouse Brain with Ischemic Stroke Through AMP-Activated Protein Kinase Activation." 08/01/2022 - "In the present study, we investigated the potential role of nicotinamide mononucleotide adenylyltransferase 1 (NMNAT1) in ischemia-induced BBB damage using an animal middle cerebral artery occlusion (MCAO) model of ischemic stroke. "
5.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 08/01/2022 - "In the present study, we investigated the potential role of nicotinamide mononucleotide adenylyltransferase 1 (NMNAT1) in ischemia-induced BBB damage using an animal middle cerebral artery occlusion (MCAO) model of ischemic stroke. "

Related Drugs and Biologics

1.	Enzymes
2.	NAD (NADH)
3.	NAD+ synthase
4.	Proteins (Proteins, Gene)
5.	Ubiquitin
6.	Adenosine Triphosphate (ATP)
7.	Sirtuin 1
8.	AMP-Activated Protein Kinases
9.	Alpha-Amanitin
10.	Proteasome Endopeptidase Complex (Proteasome)