Nitroxinil (Nitroxynil)

03/01/1976 - "The results showed that the efficacy of nitroxynil and the occurrence of structurally abnormal flukes were directly proportional to the age of infection at treatment. "
01/01/1995 - "Treatment of a 20-week infection with nitroxynil was followed by a slow decrease in antibody titre 4 weeks later. "
08/28/1982 - "Administered by subcutaneous injection, nitroxynil and rafoxanide at dose rates of 10 and 3 mg/kg bodyweight respectively were 88.5 and 36.1 per cent effective in eliminating a six-week-old infection of F hepatica and 85.8 and 60.4 per cent effective against an eight-week-old infection. "
03/28/2015 - "Egg reappearance interval following housing treatment was eight weeks for clorsulon and 13 weeks for nitroxynil, though patent infections in both groups developed in only a small minority of animals; no fluke eggs were recovered from cattle treated with triclabendazole. "
08/28/1982 - "The anthelmintic activities of nitroxynil, closantel and rafoxanide were tested in cattle against six- and eight-week-old infections of Fasciola hepatica. "

05/01/1991 - "On the basis of faecal examinations, the 30 animals were subdivided in negative (group A; n = 10) and positive animals (n = 20) for fascioliasis, the latter being either treated with nitroxinil (group B; n = 10) or not (group C; n = 10) on day 0 of this trial which was conducted during 75 days. "
03/01/1984 - "These results suggest that in bovine fascioliasis the in vivo metabolism of nitroxynil will be decreased with consequent increase of nitroxynil retention in the animal's body."
01/10/1970 - "The efficac of nitroxynil in the treatment of naturally-occurring ovine fascioliasis."
03/01/1984 - "Impaired in vitro metabolism of the flukicidal agent nitroxynil by hepatic microsomal cytochrome P-450 in bovine fascioliasis."
06/15/2023 - "Nitroxynil (NTX) is a common anthelmintic veterinary drug for the management of fascioliasis in food-producing sheep and cattle. "

04/01/2010 - "The effect of age/body weight in the plasma disposition kinetics of ivermectin (IVM) and nitroxynil (NTX) after their co-administration as a combined formulation to sheep was studied. "
04/01/2010 - "Combined subcutaneous administration of ivermectin and nitroxynil in sheep: age/body weight related changes to the kinetic disposition of both compounds."

11/24/2010 - "Unfortunately, it is commonly believed that bacterial infections induced by nasal bots are of greater clinical importance: this view is not substantiated and the control of this condition depends on treatment with macrocyclic lactones, closantel and nitroxynil. "