Nitroimidazoles

02/01/1981 - "Therapeutic efficacy of several nitroimidazoles for experimental Trypanosoma cruzi infections in mice."
09/01/2006 - "The most commonly administered treatments are betalactams agents combined to anti-anaerobes drugs such as nitroimidazoles, adapted to the location of infection. "
07/01/1997 - "Its activity against hepatic infection in golden hamsters is comparable with that of different derivatives of nitroimidazoles used for human treatment. "
01/01/1985 - "The nitroimidazoles used in the treatment of anaerobic infection are well-tolerated by patients. "
03/01/1984 - "[Treatment using nitroimidazoles in orofacial infections]."

03/01/2005 - "Entamoeba histolytica, the causative agent of amoebiasis, may develop resistance to nitroimidazoles, a group of drugs considered to be the most effective against this parasitic disease. "
11/01/1970 - "Therapeutic efficacy of new nitroimidazoles for experimental trichomoniasis, amebiasis, and trypanosomiasis."
09/01/2012 - "After decades of the introduction of MTZ and other nitroimidazoles in the therapy of amebiasis, there have been few innovations in treating amebic infections. "
02/01/1984 - "Nitroimidazoles in the treatment of trichomoniasis, giardiasis, and amebiasis."
09/01/2012 - "Metronidazole (MTZ), which is the drug of choice for invasive amebiasis, and other nitroimidazoles have greatly simplified the chemotherapy of this disease. "

09/01/2005 - "Despite five published randomized trials, evidence supporting the use of nitroimidazoles in the treatment of cervical cancer is lacking. "
01/01/1983 - "This study is part of a clinical program to assess the use of nitroimidazoles as radiosensitizers of hypoxic tumor cells. "
09/01/2011 - "Finally, we also discuss the prospect and developmental trend of nitroimidazoles as anti-tumor agents."
09/01/2011 - "In this review, we focus on the development of nitroimidazoles as radiosensitizer, bio-reductive prodrug and other types of anti-tumor agents for cancer therapy, and the mechanism of acting as anti-tumor agents. "
09/01/2011 - "Nitroimidazoles is a kind of radiosensitizer with multiple bioactivities used in cancer treatment since 1950s. "

05/26/1995 - "bis(nitroimidazoles) and related Bis(nitroheterocycles): development of derivatives with higher rates of metabolic activation under hypoxia and improved aqueous solubility."
11/19/2014 - "Toward this goal, we developed two hypoxia-sensitive imaging agents based on nitroimidazoles which are capable of accumulating in hypoxic cells in vivo. "
03/21/2012 - "Nitroimidazoles, a thoroughly investigated class of hypoxia selective drugs, have been shown to be highly retained in hypoxic tissues. "
10/01/2011 - "Nitroimidazoles showed physicochemical properties with poor tissue diffusion, less antioxidant redox potential and long retention time in tissue making them poor choice of hypoxia markers. "
01/01/2007 - "Finally, the evaluation of hypoxia with nitroimidazoles may be a valuable tool for prognosis and therapy planning."

02/15/2010 - "Long-term treatment with nitroimidazoles or clofazimine appears to be effective in patients with Crohn's disease."
01/01/1985 - "The observed low general toxicity of nitroimidazoles is consistent with the non-occurrence of nitroreduction, as is the absence of chromosomal aberration in the circulating lymphocytes of patients receiving prolonged metronidazole therapy for Crohn's disease. "
03/01/2000 - "The most commonly used antibiotics in Crohn's disease are nitroimidazoles and macrolides often combined with corticosteroids or sulfasalazine. "