Nitrofurantoin (Macrodantin)

A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression.

Also Known As:

Networked: 731 relevant articles (47 outcomes, 58 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Harbarth, Stephan: 4 articles (09/2015 - 10/2013)
2.	Mamdani, Muhammad M: 4 articles (03/2015 - 04/2010)
3.	Juurlink, David N: 4 articles (03/2015 - 04/2010)
4.	Koren, Gideon: 4 articles (02/2015 - 02/2007)
5.	Cunha, Burke A: 4 articles (02/2015 - 12/2011)
6.	Hooton, Thomas M: 4 articles (11/2007 - 06/2003)
7.	Stewardson, Andrew: 3 articles (07/2015 - 10/2013)
8.	Antoniou, Tony: 3 articles (03/2015 - 06/2010)
9.	Gomes, Tara: 3 articles (03/2015 - 06/2010)
10.	Gupta, Kalpana: 3 articles (10/2014 - 07/2005)

Related Diseases

1.	Urinary Tract Infections (Urinary Tract Infection) 10/01/2010 - "Nitrofurantoin shows good efficacy against most bacteria expected in urinary tract infection, and the development of resistance is low. " 10/01/2010 - "The results of the present study indicate good antimicrobial and clinical efficacy of nitrofurantoin in the treatment of acute uncomplicated urinary tract infections as well as acceptable tolerability in adults." 10/12/2012 - "Nitrofurantoin has been in use since 1953 as an effective agent for the prevention of recurrent urinary tract infection. " 01/01/1983 - "Nitrofurantoin is equally effective in urinary tract infections. " 12/01/1981 - "Three days of treatment with nitrofurantoin macrocrystals is an effective regimen for symptomatic girls presumed to have uncomplicated lower urinary tract infections."
2.	Infection 08/01/2004 - "Antibiotic/beta-lactam inhibitor and nitrofurantoin are effective for urogenital infections caused by E. " 10/01/2000 - "The regimen with nitrofurantoin failed to eradicate infection from any of the six SS1-infected mice (P < or =0.001) and cleared infection from one of seven mice inoculated with the rdxA mutant. " 02/01/2011 - "Re: Bag et al.: One week of nitrofurantoin before percutaneous nephrolithotomy significantly reduces upper tract infection and urosepsis: a prospective controlled study (Urology 2010;77:45-49)." 01/01/2011 - "One week of nitrofurantoin before percutaneous nephrolithotomy significantly reduces upper tract infection and urosepsis: a prospective controlled study." 08/21/1954 - "Nitrofurantoin: a study in vitro and in vivo in one hundred cases of urinary infection."
3.	Bacteriuria 02/01/2009 - "To evaluate whether a 1-day nitrofurantoin regimen is as effective as a 7-day regimen in eradicating asymptomatic bacteriuria during pregnancy. " 05/01/1999 - "Bacteriuria after combined urodynamics and cystourethroscopy was not improved by a 1-day course of nitrofurantoin." 05/01/1999 - "To determine the efficacy of prophylactic nitrofurantoin in preventing bacteriuria after urodynamics and cystourethroscopy. " 06/01/1989 - "Subsequent bacteriuria with Gram-positive cocci was eliminated by nitrofurantoin (50 mg qid) within four days. " 09/01/1975 - "A short course of nitrofurantoin eliminated the bacteriuria in 93% of the girls in the treatment group. "
4.	Cystitis 11/12/2007 - "There is a paucity of data on the efficacy of nitrofurantoin for the treatment of acute uncomplicated cystitis in regimens shorter than 7 days. " 09/01/2015 - "The change was predominately driven by an increase in nitrofurantoin use for cystitis from 12% to 80% (difference, 68%; 95% CI, 62%-73%; P < .001). " 01/01/2015 - "Bacterial cystitis was prevented by continuous administration of nitrofurantoin. " 12/01/2014 - "coli, nitrofurantoin remains a reliable first-line agent for the empirical treatment of acute uncomplicated cystitis." 05/01/2010 - "In addition, she was on the ninth day of a 10-day course of nitrofurantoin for acute cystitis. "
5.	Pyelonephritis 08/15/1983 - "Pyelonephritis in pregnancy: a prospective randomized trial to prevent recurrent disease evaluating suppressive therapy with nitrofurantoin and close surveillance." 03/01/1982 - "[Studies on the kinetics of nitrofurantoin (Nifurantin) in normal pregnancy, gestoses, pyelonephritis and labor (author's transl)]." 06/15/1976 - "The exclusive application of nitrofurantoin or an only symptomatic therapy is not indicated in acute pyelonephritis. " 01/01/1969 - "A comparison of the antibacterial effect of nitrofurantoin and two nitrofuran compounds on experimental Escherichia coli pyelonephritis." 01/01/1964 - "LONG-TERM FOLLOW-UP ON THE NITROFURANTOIN TREATMENT OF PATIENTS WITH CHRONIC PYELONEPHRITIS."

Related Drugs and Biologics

1.	Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)
2.	Trimethoprim (Proloprim)
3.	Ciprofloxacin (Cipro)
4.	Fosfomycin
5.	Ampicillin (Omnipen)
6.	bismuth subsalicylate (Pepto-bismol)
7.	Norfloxacin
8.	Amoxicillin (Wymox)
9.	Anti-Bacterial Agents (Antibiotics)
10.	Cephalexin (Cefalexin)

Related Therapies and Procedures

1.	Antibiotic Prophylaxis
2.	Transplants (Transplant)
3.	Stents
4.	Catheters
5.	Drug Therapy (Chemotherapy)