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Nitrendipine

A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
Also Known As:
Balminil; Bay e 5009; Bayotensin; Baypresol; Baypress; Gericin; Jutapress; Nidrel; Niprina; Nitre AbZ; Nitre-Puren; Nitregamma; Nitren 1A Pharma; Nitren Lich; Nitren acis; Nitrend KSK; Nitrendepat; Nitrendi Biochemie; Nitrendidoc; Nitrendimerck; Nitrendipin AL; Nitrendipin Apogepha; Nitrendipin Atid; Nitrendipin Basics; Nitrendipin Heumann; Nitrendipin Jenapharm; Nitrendipin Lindo; Nitrendipin Stada; Nitrendipin beta; Nitrendipin-ratiopharm; Nitrendipino Bayvit; Nitrendipino Ratiopharm; Nitrensal; Nitrepress; Tensogradal; Trendinol; Vastensium; nitrendipin von ct; nitrendipin-corax; Nitre Puren; NitrePuren; Nitrendipin ratiopharm; Nitrendipinratiopharm; nitrendipin corax; nitrendipincorax; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, ethyl methyl ester
Networked: 559 relevant articles (73 outcomes, 135 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Staessen, J A: 8 articles (12/2004 - 01/2000)
2. Birkenhäger, W H: 4 articles (12/2004 - 07/2000)
3. Thijs, L: 4 articles (07/2003 - 03/2001)
4. Wang, J G: 4 articles (12/2001 - 01/2000)
5. Kuwahara, Koichiro: 3 articles (01/2016 - 09/2009)
6. Nakao, Kazuwa: 3 articles (01/2016 - 09/2009)
7. Staessen, Jan A: 3 articles (04/2010 - 10/2001)
8. Thijs, Lutgarde: 3 articles (04/2010 - 10/2001)
9. Lüders, Stephan: 3 articles (09/2009 - 03/2005)
10. Forette, F: 3 articles (01/2003 - 07/2000)

Related Diseases

1. Hypertension (High Blood Pressure)
2. Essential Hypertension
3. Ischemia
09/01/1997 - "The number of L-type Ca2+ channels, measured by nitrendipine binding, was reduced by 21% after 60 min of ischemia. "
02/01/1992 - "Nitrendipine slightly attenuated ischemia/reperfusion-induced decrease in AF. "
01/01/1991 - "The duration of ischemia (37 +/- 43 vs. 5 +/- 9 min, p less than 0.05) as well as the AUC (41 +/- 45 vs. 7 +/- 14 mm/min, p less than 0.05) were reduced only by nitrendipine. "
11/01/1994 - "Group II (n = 6) received SOD 7.0 mg/kg. Group III (n = 6) received nitrendipine 1 mg/kg. Group IV (n = 6) received nitrendipine 1 mg/kg and SOD 7 mg/kg. After administration, both kidneys were rendered ischemic by cross-clamping the renal vessels for 60 min. Comparison of 24-h creatinine clearance (CCr) for 3 days after reversal of ischemia revealed: (a) nitrendipine alone was the most effective in preserving renal function (p < .05); (b) SOD provided some degree of improvement, but only on day 3 (p < .05); (c) a similar result was detected using a combination of nitrendipine and SOD (p < .05); (d) there was no significant difference between SOD and nitrendipine nor between SOD and the combination of nitrendipine/SOD; (e) there was a significant improvement with nitrendipine when compared to the combination of nitrendipine/SOD (p < .05)."
12/01/1990 - "Comparison of 24-h creatinine clearances for 72 h after reversal of ischemia demonstrated that nitrendipine was capable of providing a degree of protection against renal ischemia and the protective effect was dose dependent (p less than .05)."
4. Stroke (Strokes)
5. Isolated Systolic Hypertension

Related Drugs and Biologics

1. Antihypertensive Agents (Antihypertensives)
2. Calcium
3. Calcium Channel Blockers (Blockers, Calcium Channel)
4. Captopril (Capoten)
5. Enalapril
6. 1,4-dihydropyridine (dihydropyridine)
7. Amlodipine (Norvasc)
8. Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
9. Calcium Channels (Calcium Channel)
10. Creatinine

Related Therapies and Procedures

1. Therapeutics
2. Oral Administration
3. Intra-Arterial Infusions
4. Secondary Prevention
5. Aftercare (After-Treatment)