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Niflumic Acid

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An analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.

Also Known As:

Donalgin; Flunir; Niflactol; Niflugel; Nifluril; UPSA Brand 1 of Niflumic Acid; UPSA Brand 2 of Niflumic Acid; UPSA Conseil Brand of Niflumic Acid; Upsamedica Brand of Niflumic Acid; Acid, Niflumic; 3-Pyridinecarboxylic acid, 2-((3-(trifluoromethyl)phenyl)amino)-

Networked: 99 relevant articles (4 outcomes, 9 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Cremonesi, Giovanni: 1 article (06/2015)
2.	Cavalieri, Luca: 1 article (06/2015)
3.	Chen, Zirong: 1 article (01/2015)
4.	Fallahi, Mohammad: 1 article (01/2015)
5.	Cress, W Douglas: 1 article (01/2015)
6.	Wang, Ziyou: 1 article (01/2015)
7.	Gao, Ruli: 1 article (01/2015)
8.	Liao, Dan: 1 article (01/2015)
9.	Welsh, Eric A: 1 article (01/2015)
10.	Hu, Chengbin: 1 article (01/2015)

Related Diseases

1.	Inflammation 01/01/1990 - "The combination of Nifluril with antibiotic therapy gave significantly greater relief from abnormalities of the tympanic membrane (after two days treatment), inflammation of the throat and nasal congestion than did antibiotic therapy alone. " 10/31/1985 - "[Niflumic acid in otorhynolaryngologic inflammation in childhood. " 06/01/1996 - "In rats without peripheral inflammation the NSAID, flunixin, a niflumic acid derivative, had only a small effect that was not dose-dependent. " 01/01/1985 - "Use of acute phase protein changes to assess the effects of a nonsteroidal antiinflammatory drug (niflumic acid) on the inflammation process induced by limited plastic surgery." 12/01/2005 - "Therefore, in order to establish the viability of PLA(2) as a potential target molecule for drug design against inflammation, arthritis and rheumatism, the three-dimensional structure of the complex of PLA(2) with the known anti-inflammatory agent niflumic acid [2-[3-(trifluoromethyl)anilino]nicotinic acid] has been determined at 2.5 Angstroms resolution. "
2.	Pain (Aches) 05/01/1974 - "[Treatment of arthrotic pain through short cures of niflumic acid]." 08/01/2008 - "Breakthrough pain (visual analog scale >30 mm) was treated with niflumic acid suppositories 700 mg every 12 h. " 01/01/1990 - "Clinical assessments before and after 2 and 4 days of treatment showed that there was faster resolution of fever, pain, adenopathy, pharyngeal congestion and dysphagia, and improved patient comfort in the niflumic acid group. " 06/01/2015 - "Morniflumate, the ß-morpholinoethyl ester of niflumic acid, is a member of the fenamate family of NSAIDs indicated for the treatment of inflammatory conditions (with or without pain) affecting airways, the ENT system, urogenital tract and the osteoarticular system. " 09/01/2010 - "Post-operative pain was evaluated using VAS or CHIPPS scores values at h1, h6, h12, h18, h24, h36 and h48, as well as doses of first line (paracetamol 15 mg/kg/6h) or second line rescue analgesia (0.2mg/kg intravenous nalbuphine), if pain score remained high after 30 mm. niflumic acid was systematically used. "
3.	Sprains and Strains (Sprain) 01/01/1990 - "The study findings indicate that treatment with topical niflumic acid gel is effective in treating uncomplicated ankle sprains and results in improved clinical signs on Day 4 and after 7 days." 01/01/1990 - "A double-blind, placebo-controlled, multi-centre study was carried out to assess the efficacy and tolerability of percutaneous niflumic acid gel in the treatment of uncomplicated ankle sprains. " 01/01/1990 - "The results showed that topically applied 2.5% niflumic acid gel was superior to placebo in the treatment of ankle sprains in respect of all major parameters studied. " 01/01/1990 - "Clinical evaluation of niflumic acid gel in the treatment of uncomplicated ankle sprains."
4.	Fever (Fevers) 01/01/1990 - "Clinical assessments before and after 2 and 4 days of treatment showed that there was faster resolution of fever, pain, adenopathy, pharyngeal congestion and dysphagia, and improved patient comfort in the niflumic acid group. " 01/01/1990 - "A double-blind, placebo-controlled study was carried out in 231 adult patients suffering from acute diffuse pharyngitis or acute tonsillitis with fever and dysphagia to assess the effectiveness of niflumic acid combined with standard antibiotic therapy in relieving pain and inflammation. "
5.	Deglutition Disorders (Dysphagia) 01/01/1990 - "Clinical assessments before and after 2 and 4 days of treatment showed that there was faster resolution of fever, pain, adenopathy, pharyngeal congestion and dysphagia, and improved patient comfort in the niflumic acid group. " 01/01/1990 - "A double-blind, placebo-controlled study was carried out in 231 adult patients suffering from acute diffuse pharyngitis or acute tonsillitis with fever and dysphagia to assess the effectiveness of niflumic acid combined with standard antibiotic therapy in relieving pain and inflammation. "

Related Drugs and Biologics

1.	Niflumic Acid
2.	Indomethacin (Indometacin)
3.	Suppositories (Vaginal Suppositories)
4.	Adrenal Cortex Hormones (Corticosteroids)
5.	morniflumate
6.	Arachidonic Acid (Vitamin F)
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8.	Sodium
9.	Nordihydroguaiaretic Acid (Masoprocol)
10.	Butyrates (Butyrate)

Related Therapies and Procedures

1.	Analgesia