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Niclofolan

Proposed fasciolacide. Synonyms: Dertil; Bilevon; Bay 9015.

Also Known As:

Bayer 3625; Bayer 9015; Bilevon M; Bilevon R; Dertil; Distolon; Distolone; Niclofan; 3625, Bayer; 9015, Bayer; M, Bilevon; R, Bilevon; Menichlopholan; (1,1'-Biphenyl)-2,2'-diol, 5,5'-dichloro-3,3'-dinitro-

Networked: 25 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 58

Related Diseases

1.	Infection 12/01/1985 - "dose, of niclofolan is not absorbed and/or metabolized sufficiently to prevent elimination of the infection." 06/01/1984 - "Trematodiasis in Turkey: comparative efficacy of triclabendazole and niclofolan against natural infections of Fasciola hepatica and F. " 07/01/1977 - "Menichlopholan, biphenyl compound, in a single dose of 2 mg/kg body weight, gave a 73%-90% cure rate in the treatment of pulmonary infections due to Paragonimus uterobilateralis at two centers in Nigeria. " 01/01/1984 - "Although Hetol (or hexachloroparaxylol), prolonged administration of oral dehydroemetine and only two doses of niclofolan showed therapeutic effect on Clonorchis infection, side effects were observed in most of the treated cases. "
2.	Paragonimiasis 05/01/1980 - "[Preliminary observation on the treatment of paragonimiasis westermani (thoracic type) with domestic niclofolan in 26 cases (author's transl)]." 07/01/1977 - "The advantages of single dose therapy are likely to make menichlopholan the treatment of choice for paragonimiasis in Africa, and probably elsewhere." 07/01/1977 - "Single dose therapy of paragonimiasis with menichlopholan." 12/01/1990 - "Various drugs have been introduced for the treatment of paragonimiasis, and among them, bithionol, niclofolan and praziquantel have shown high therapeutic efficacy. "
3.	Body Weight (Weight, Body) 05/01/1980 - "51 refugees from South east Asia infected with Opisthorchis viverrini or Clonorchis sinensis were included in a therapeutic study with Niclofolan (Bay 9015) at a dose of 1 mg/kg body weight given three times at intervals of 48 hours. " 01/01/1984 - "A single dose of 2 mg/kg body weight of niclofolan yielded 100% cure rate. " 05/01/1981 - "Niclofolan given orally in a single dose of 2 mg/kg body weight showed a 100% cure rate. " 01/01/1981 - "The Niclofolan (Bayer) is the ultimate progress in the treatment at a single dose of 2 mg per kilo body weight, its efficiency is much superior to the classic treatments (Emetin, Chloroquin, Bithionol), except in some pleural forms." 07/01/1977 - "Menichlopholan, biphenyl compound, in a single dose of 2 mg/kg body weight, gave a 73%-90% cure rate in the treatment of pulmonary infections due to Paragonimus uterobilateralis at two centers in Nigeria. "
4.	Opisthorchiasis 03/01/1981 - "A clinical trial of Niclofolan on human opisthorchiasis was carried out in 60 patients admitted to the Hospital for Tropical Diseases. " 05/01/1980 - "Niclofolan did not reveal to be the ideal treatment of opisthorchiasis. " 05/01/1980 - "[Clinical trial of niclofolan (Bay 9015) in the treatment of human opisthorchiasis. " 03/01/1981 - "Studies on the chemotherapy of human opisthorchiasis: II. Clinical trial of niclofolan."
5.	Poisoning 01/01/1989 - "[Accidental Dertil poisoning in children]." 06/01/1974 - "[Distolon poisoning in children]." 03/15/1973 - "[Very severe accidental poisoning with distolon in a 20-month-old infant]." 02/01/1972 - "[Severe and long-lasting disorders of basal metabolism in acute distolon poisoning]." 03/18/1970 - "[Distolone poisoning]."

Related Drugs and Biologics

1.	Bithionol (Bitin)
2.	Praziquantel (Biltricide)
3.	triclabendazole
4.	Niclofolan
5.	diphenyl (biphenyl)
6.	Rafoxanide
7.	Oxyclozanide
8.	Dovenix
9.	dehydroemetine
10.	tribromsalan

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Oral Administration