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Nicardipine (Dagan)

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A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.

Also Known As:

Dagan; Y93; Y 93; Cardene; Y-93; Almirall Brand of Nicardipine Hydrochloride; Antagonil; Cardene I.V.; Cardene SR; ESP Pharma Brand of Nicardipine Hydrochloride; Farma Lepori Brand of Nicardipine Hydrochloride; Flusemide; Lecibral; Lincil; Loxen; Lucenfal; Nicardipine Hydrochloride; Nicardipine LA; Nicardipino Ratiopharm; Nicardipino Seid; Novartis Brand of Nicardipine Hydrochloride; Perdipine; Ratiopharm Brand of Nicardipine Hydrochloride; Ridene; Roche Brand of Nicardipine Hydrochloride; Seid Brand of Nicardipine; Solvay Brand of Nicardipine Hydrochloride; Syntex Brand of Nicardipine Hydrochloride; Tedec Meiji Brand of Nicardipine Hydrochloride; UCB Brand of Nicardipine Hydrochloride; Vasonase; Yamanouchi Brand 1 of Nicardipine Hydrochloride; Yamanouchi Brand 2 of Nicardipine Hydrochloride; Yamanouchi Brand 3 of Nicardipine Hydrochloride; Hydrochloride, Nicardipine; LA, Nicardipine; Nicardipine Seid Brand; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 2-(methyl(phenylmethyl)amino)ethyl ester

Networked: 1020 relevant articles (152 outcomes, 195 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Pyridines: 41
    - Dihydropyridines: 177
      - Nicardipine: 1020
        2-(N-benzyl-N-methylamino)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
        XE 820

Experts

1.	Kasuya, Hidetoshi: 11 articles (01/2013 - 04/2002)
2.	Peacock, W Frank: 7 articles (07/2014 - 06/2009)
3.	Qureshi, Adnan I: 6 articles (07/2012 - 07/2006)
4.	Schmiedek, Peter: 6 articles (12/2011 - 02/2007)
5.	Varon, Joseph: 5 articles (07/2014 - 06/2009)
6.	Longrois, Dan: 5 articles (02/2013 - 07/2005)
7.	Barth, Martin: 5 articles (12/2011 - 02/2007)
8.	Vajkoczy, Peter: 5 articles (11/2011 - 02/2007)
9.	Amenta, Francesco: 5 articles (08/2009 - 10/2002)
10.	Suri, M Fareed K: 4 articles (07/2012 - 01/2007)

Related Diseases

1.	Hypertension (High Blood Pressure) 04/01/1997 - "This study confirms the excellent efficacy of nicardipine in the management of postoperative hypertension, but underlines the risk of poor cardiac tolerance in patients after major surgery. " 07/01/2003 - "The first-generation (nicardipine) agents have proven efficacy against hypertension. " 02/01/1995 - "Intravenous nicardipine titration, starting with 10 mg/hr and increased slowly every 4 minutes by the rate 1 mg/hr until target supine DBP of 90 mmHg was achieved, was a very effective and safe method for patients with very severe hypertension. " 12/01/1989 - "This study indicates that nicardipine is an effective, long lasting, and safe therapy for intraoperative hypertension during abdominal surgery." 11/01/1990 - "The authors conclude that nicardipine HC1 is an effective, safe therapy for postoperative hypertension. "
2.	Intracranial Vasospasm 12/01/2011 - "Intracisternal nicardipine prolonged release implants (NPRI) have been shown to be effective in the prophylaxis of cerebral vasospasm (VS). " 12/01/2000 - "These results suggested that nicardipine-prolonged release preparation is safe as well as effective for cerebral vasospasm." 09/01/2012 - "Intra-arterial nicardipine is an effective and safe treatment for cerebral vasospasm. " 02/01/2009 - "Based on these positive results, we believe that larger scale studies evaluating the safety and efficacy of IT nicardipine for the management of cerebral vasospasm are warranted." 10/01/2011 - "We present a case of diffuse cerebral vasospasm, which improved with intra-arterial nicardipine. "
3.	Angina Pectoris 03/01/1993 - "Nicardipine monotherapy has also demonstrated efficacy in angina pectoris and shown promise in the management of ischaemia-related cerebrovascular diseases, notably subarachnoid haemorrhage." 01/01/1985 - "Nicardipine was effective in the treatment of stable effort angina pectoris; this benefit was maintained for the entire year of treatment." 06/30/1987 - "Nicardipine appears to be safe and effective in the management of patients with angina pectoris." 01/01/1985 - "This study evaluated 1 year the efficacy of therapy with nicardipine in patients with chronic stable angina pectoris. " 01/01/1990 - "Efficacy of nicardipine in angina pectoris."
4.	Myocardial Ischemia (Ischemic Heart Diseases) 04/01/1999 - "Larger studies are required to verify the efficacy of nicardipine in reducing the severity of myocardial ischemia during cardiac surgery." 09/01/1987 - "During atrial pacing, the heart rate threshold for myocardial ischemia was not changed by nicardipine administration, despite improvement in the ratio of coronary blood flow to myocardial oxygen consumption and hemodynamic changes otherwise similar to those during exercise. " 02/01/1999 - "Our results suggest that nicardipine lessened the severity of myocardial ischemia shortly after coronary revascularization and could be considered as an alternative to standard antiischemic therapy." 03/01/1993 - "Beneficial effect of nicardipine on perioperative myocardial ischemia." 10/01/1991 - "[Effects of nicardipine on the functional state of the liver in patients with ischemic heart disease]."
5.	Spasm (Spasms) 01/01/1989 - "These findings demonstrate that IC nicardipine is safe and could be effective in the reversal of coronary artery spasm in patients with variant angina." 03/01/2000 - "During the first day of treatment the percentage of cerebral hemispheres diagnosed as having suspected spasm was 11.1% for nicardipine and 64.3% for the placebo (p = 0.02881). " 08/01/1999 - "Nicardipine infusion for radial artery spasm--a cautionary note." 01/01/1993 - "Experimental basilar artery spasm caused by autologous blood application: effects of clot removal and topical nicardipine." 07/01/2001 - "The use of nicardipine allows the control the vasoreactivity of the radial graft without totally obviating at least angiographic spasm. "

Related Drugs and Biologics

1.	Calcium
2.	Nitroprusside (Sodium Nitroprusside)
3.	Calcium Channels (Calcium Channel)
4.	Nifedipine (Adalat)
5.	Verapamil (Calan)
6.	Nitroglycerin (Dynamite)
7.	Labetalol (Normodyne)
8.	1,4-dihydropyridine (dihydropyridine)
9.	Propranolol (Inderal)
10.	Diltiazem (Cardizem)

Related Therapies and Procedures

1.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)
2.	Intravenous Infusions
3.	Transplants (Transplant)
4.	Sternotomy
5.	Microspheres (Microsphere)