Newcastle Disease

An acute febrile, contagious, viral disease of birds caused by an AVULAVIRUS called NEWCASTLE DISEASE VIRUS. It is characterized by respiratory and nervous symptoms in fowl and is transmissible to man causing a severe, but transient conjunctivitis.

Also Known As:

Networked: 1081 relevant articles (103 outcomes, 127 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Influenza in Birds (Avian Flu)
2.	Marek Disease (Marek's Disease)
3.	Bronchitis
4.	Infections
5.	Fowlpox

Experts

1.	Hu, Yuanliang: 19 articles (05/2016 - 05/2005)
2.	Wang, Deyun: 18 articles (01/2022 - 05/2005)
3.	Afonso, Claudio L: 15 articles (10/2021 - 10/2007)
4.	Dimitrov, Kiril M: 13 articles (10/2021 - 03/2010)
5.	Miller, Patti J: 11 articles (08/2021 - 10/2007)
6.	Liu, Jiaguo: 9 articles (01/2022 - 05/2005)
7.	Fan, Yunpeng: 9 articles (03/2015 - 05/2010)
8.	Yu, Qingzhong: 8 articles (10/2021 - 03/2009)
9.	Samal, Siba K: 8 articles (01/2020 - 03/2010)
10.	Lambrecht, Bénédicte: 7 articles (07/2021 - 06/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Newcastle Disease:

1.	VaccinesIBA 06/20/2017 - "While vaccination remains the single most important means for controlling Newcastle disease, presence of MDA may interfere with the vaccination of young birds and decrease the efficacy of the vaccine. " 09/01/2009 - "Efficacy of a genotype 2 Newcastle disease vaccine (Avinew) against challenge with highly virulent genotypes 5d and 3d." 10/15/2021 - "This improved survival and the dose-dependency data suggest that novel attenuated in ovo rNDV-based vaccines that are able to penetrate maternal immunity to elicit a strong immune response as early as 14 days post-hatch, resulting in high or full protection from virulent challenge, show promise as a contributor to the control of Newcastle disease." 09/01/2014 - "It indicated that SGSC could significantly improve the immune efficacy of Newcastle disease vaccine, and would be as the candidate of a new-type immune adjuvant. " 08/01/2013 - "It indicated that CMP40 fraction and CMP50 fraction could significantly improve the immune efficacy of Newcastle disease vaccine, and would be as the candidate of a new-type immune adjuvant."
2.	EmulsionsIBA 11/07/1981 - "The results show that birds were as well protected and grew at least as well when vaccinated at one day old and that the special low-dose oil emulsion gave as good protection against Newcastle disease as the higher dose vaccine. " 01/01/1998 - "Efficacy of combined killed-in-oil emulsion and live Newcastle disease vaccines in chickens." 01/01/1991 - "The preparation and efficacy of manually emulsified Newcastle disease oil-emulsion vaccines." 01/01/1989 - "Efficacy of oil-emulsion vaccines prepared with pigeon paramyxovirus-1, Ulster, and La Sota Newcastle disease viruses." 07/01/1983 - "Influence of formulation on the efficacy of experimental oil-emulsion Newcastle disease vaccines."
3.	AerosolsIBA 11/01/1993 - "Aerosol vaccination is used effectively to immunize poultry against Newcastle disease, but to the authors' knowledge, this vaccination procedure is not well studied in other species. " 04/01/1991 - "[Aerosol immunization against Newcastle disease]." 01/01/1988 - "A new, simple aerosol immunization technique against Newcastle disease." 01/01/1984 - "[Pathomorphological changes after the single aerosol vaccination of broilers against Newcastle disease]." 07/01/1981 - "Aerosol vaccination against Newcastle disease: factors affecting the serological response in chickens."
4.	Combined VaccinesIBA 03/01/2018 - "Administration of vaccines combined with the good management and strict biosecurity is an effective way for Newcastle disease (ND) control. " 09/26/2017 - "Newcastle Disease Virus Vectored Bivalent Vaccine against Virulent Infectious Bursal Disease and Newcastle Disease of Chickens." 11/01/2020 - "Comparative safety and efficacy of two bivalent vaccines containing Newcastle disease LaSota and avian influenza H9N2 Sidrap isolate formulated with different oil adjuvants." 01/01/2017 - "Efficacy of an inactivated bivalent vaccine against the prevalent strains of Newcastle disease and H9N2 avian influenza." 04/01/1993 - "Protection against hemorrhagic enteritis and Newcastle disease in turkeys by embryo vaccination with monovalent and bivalent vaccines."
5.	Hemagglutinins (Hemagglutinin)IBA 05/15/2015 - "Recombinant Newcastle disease viral vector expressing hemagglutinin or fusion of canine distemper virus is safe and immunogenic in minks." 12/01/2012 - "For the past decade, several recombinant Newcastle disease viruses (rNDV) have been used as a vector to express native or modified avian influenza (AI) hemagglutinins (HA) in order to give preventive protection against highly pathogenic avian influenza (HPAI) H5N1 viruses. " 06/01/2011 - "Efficacy of Newcastle disease virus recombinant expressing avian influenza virus H6 hemagglutinin against Newcastle disease and low pathogenic avian influenza in chickens and turkeys." 12/01/2020 - "Newcastle disease virus (NDV) vectors expressing avian influenza virus (AIV) hemagglutinin of subtype H5 protect specific pathogen-free chickens from Newcastle disease and avian influenza. " 01/01/2021 - "We coupled the computer-designed VLP not only to monomers (SARS-CoV-2) but also to cyclic dimers (Newcastle disease, Lyme disease), trimers (influenza hemagglutinins), and tetramers (influenza neuraminidases). "
6.	AntibodiesIBA 06/01/1990 - "Differences between the two study groups were evident: people having a known association with poultry showed significantly higher levels of antibodies to Newcastle disease and avian infectious bronchitis virus. " 11/01/1971 - "[Comparative studies on the development of hemagglutinating antibodies after vaccination against Newcastle disease with the strains La Sota and Hitschner B 1 and their tolerance in field trials]." 01/01/2023 - "Serology revealed no antibodies against Newcastle disease, and Salmonella spp. cultures were negative. " 01/01/2023 - "Genetic and non-genetic factors influencing KLH binding natural antibodies and specific antibody response to Newcastle disease in Kenyan chicken populations." 09/01/2018 - "Hemagglutination inhibition test was performed to determine the serum antibodies against Newcastle disease (ND) virus. "
7.	La Sota vaccineIBA 03/01/2015 - "In studies in SPF chickens, there were no negative impacts by the IBD V877 vaccine on the efficacy of a live QX-like IB vaccine and a live Newcastle disease La Sota vaccine in vaccination challenge studies, although the IBD vaccine had a negative effect on the antibody response generated by the QX-like IB vaccine. " 01/01/2017 - "The efficacy of vaccination with Newcastle disease (ND) La Sota and R2B (Mukteswar) modified live strain vaccines was determined by experimental challenge and with ND La Sota vaccine under field conditions in Nepal. " 01/01/1985 - "Six experiments were carried out with aerosol immunization, using various doses of the La Sota vaccine against Newcastle disease, and a control infection with massive amounts of the viscerotropic virus strain Pavlikeni to evaluate the duration of carrying the Newcastle disease virus. " 01/01/1977 - "Broiler chicks were vaccinated against Newcastle disease (ND) by nebulisation of live La Sota vaccine, or by intramuscular administration of inactivated oil emulsion vaccine. " 01/01/1978 - "Effective in conferring solid immunity against Newcastle disease proved the combined application of the two vaccines in the following order: treatment of day-old chicks with a vaccine against Marek's disease and vaccination of the same chicks at the age of 8 days with a vaccine against Newcastle disease (strain B1) at a half rate, employing the spray method, followed by revaccination 15 days later with the La Sota vaccine at a full rate, employing the aerosol method."
8.	Immunologic Adjuvants (Immunologic Adjuvant)IBA 01/01/2017 - "It indicated that PDM could significantly improve the immune efficacy of Newcastle disease vaccine using doses of 0.5g/L, these results are consistent with the drug acting as an immunopotentiator." 01/01/2021 - "CAvant® WO-60 as an Effective Immunological Adjuvant for Avian Influenza and Newcastle Disease Vaccine." 02/15/2007 - "The objective of this study was to investigate the immunoadjuvant effects of CpG ODN to Newcastle disease (ND) vaccine and its protective effects against ND virus in SPF chicken. " 09/01/2013 - "The immunological adjuvant activity of gypenosides liposome against Newcastle disease vaccine." 12/06/2011 - "Immunological adjuvant efficacy of glycyrrhetinic acid liposome against Newcastle disease vaccine."
9.	Proteins (Proteins, Gene)FDA Link 10/01/2018 - "In this study, we generated recombinant Newcastle disease viruses (rNDVs) expressing the S1, S2 and S proteins of IBV using reverse genetics technology. " 01/13/2021 - "The putative fusion protein cleavage site (113R-Q-K-R↓F 117) in all 32 isolates, and a 1.86 ICPI score of an isolate from a BPF chicken that had clinical signs consistent with Newcastle disease, confirmed the high virulence of the NDVs. " 01/01/2020 - "Using reverse genetics, recombinant Newcastle disease viruses (rNDVs) were generated, each expressing HA1, HA2, or HA protein of H5N1 HPAIV. " 01/01/2017 - "During the 1998 to 2002 outbreaks of Newcastle disease in Australia, it was observed that the mild clinical signs seen in some chickens infected with NDV did not correlate with the viruses' virulent fusion protein cleavage site motifs or standard pathogenicity indices. " 10/01/2016 - "The complete sequence of the fusion (F) protein gene from 11 Newcastle disease viruses (NDVs) isolated from commercial poultry in Mozambique between 2011 and 2016 has been generated. "
10.	Inactivated VaccinesIBA 10/01/2001 - "It is concluded from the results of this study that fancy chickens can also successfully protected against Newcastle disease by using live and inactivated vaccines which are licensed for hybrid chickens. " 07/31/2023 - "Genotype VII Newcastle disease viruses (NDV) are still epidemic in many countries in chicken and waterfowl despite intensive vaccination with conventional live and inactivated vaccines. " 01/01/2022 - "Live and killed vaccines impart a significant role in preventing of Newcastle disease (ND) in China. " 01/01/2020 - "PAW as a promising strategy could be used to prepare inactivated vaccine for Newcastle disease." 08/01/2017 - "Specific antibody-mediated immunity in the reproductive tract of laying chickens immunized against Newcastle disease with conventional attenuated and inactivated vaccines."

Therapies and Procedures

1.	Oral Administration 10/01/2019 - "The aim of the present study was to determine the effect of oral administration of APS on jejunum mucosal immunity in chickens vaccinated against Newcastle disease (ND). " 08/01/1999 - "I. Oral administration of chicken interferon-alpha ameliorates Newcastle disease." 10/01/2019 - "Effect of the oral administration of astragalus polysaccharides on jejunum mucosal immunity in chickens vaccinated against Newcastle disease." 07/12/2011 - "This study was designed to evaluate the effect of oral administration of ginseng stem-and-leaf saponin (GSLS) on immune responses in chickens vaccinated with live Newcastle disease (ND) vaccines. " 07/12/2011 - "Effect of oral administration of ginseng stem-and-leaf saponins (GSLS) on the immune responses to Newcastle disease vaccine in chickens."
2.	Microspheres (Microsphere) 05/01/2009 - "Multicolor quantum dot-encoded microspheres for the fluoroimmunoassays of chicken newcastle disease and goat pox virus." 03/01/2014 - "Development of a duplex Fluorescent Microsphere Immunoassay (FMIA) for the detection of antibody responses to influenza A and newcastle disease viruses." 05/01/2009 - "Two different antigens, Chicken newcastle disease (CND) antigen and goat pox virus (GPV) antigen, were conjugated to two kinds of biofunctional multicolor microspheres with different optical encoding. " 12/01/1953 - "Results of this procedure are compared with those of titrations based on egg infectivity and the polystyrene microsphere electron micrography for influenza virus; and with plaque count titrations on chick embryo cell monolayers in the case of the virus of Newcastle disease. " 08/01/2007 - "[Study on immune efficacy of Newcastle disease chitosan microsphere vaccine]."
3.	Intranasal Administration 04/01/2019 - "In this study, 24 specific pathogen free (SPF) chickens of white leghorn breed were infected with Newcastle disease (ND) by intranasal administration of 10⁵ 50% EID50/0.1 mL of velogenic NDV (vNDV). " 11/01/2017 - "Quaternized chitosan nanoparticles loaded with the combined attenuated live vaccine against Newcastle disease and infectious bronchitis elicit immune response in chicken after intranasal administration."
4.	Chinese Traditional Medicine (Traditional Chinese Medicine) 01/01/2022 - "In this study, the potential targets and mechanisms of action of Honeysuckle against Newcastle disease were explored through network pharmacology, which provided a theoretical basis for the treatment of Newcastle disease and provided new ideas for the development of traditional Chinese medicine for the poultry industry."
5.	Therapeutics 09/01/1984 - "Production of IFN-alpha induced by two viruses (Sendai and Newcastle disease viruses) was normal in the six untreated patients, but significantly lower in the patients on IFN therapy. " 01/01/2020 - "We propose that chIFN-α therapy via oral route could be an important therapeutic tool to control NDV infection in chicken.IMPORTANCE Newcastle disease (ND) is an economically important contagious disease of wild and domestic birds worldwide. " 11/01/2002 - "This article explores the principles of viral therapy for cancer and the past several decades of investigations with viruses such as Egypt 101, mumps, Newcastle disease, influenza, vaccinia, herpes simplex, and adenovirus serotype 5." 07/01/2010 - "These results indicated that the M gene 641 and 827 sites represent potential antiviral therapy targets, and RNAi targeting of the M gene could not only represent an effective treatment in Newcastle disease but also aid as a method for studying the replication of NDV."