Newcastle Disease

An acute febrile, contagious, viral disease of birds caused by an AVULAVIRUS called NEWCASTLE DISEASE VIRUS. It is characterized by respiratory and nervous symptoms in fowl and is transmissible to man causing a severe, but transient conjunctivitis.

Also Known As:

Networked: 493 relevant articles (41 outcomes, 34 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Influenza in Birds (Avian Flu)
2.	Marek Disease (Marek's Disease)
3.	Bronchitis
4.	Infection
5.	Enteritis

Experts

1.	Hu, Yuanliang: 10 articles (09/2013 - 05/2005)
2.	Wang, Deyun: 9 articles (09/2013 - 05/2005)
3.	Lambrecht, Bénédicte: 6 articles (12/2012 - 06/2004)
4.	Claassen, I: 5 articles (06/2015 - 01/2002)
5.	van den Berg, Thierry: 5 articles (12/2012 - 06/2009)
6.	Yu, Qingzhong: 4 articles (06/2015 - 03/2009)
7.	Liu, Jiaguo: 4 articles (09/2013 - 05/2005)
8.	Fan, Yunpeng: 4 articles (11/2012 - 05/2010)
9.	Guo, Liwei: 4 articles (11/2012 - 05/2010)
10.	Parmentier, H K: 4 articles (02/2010 - 06/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Newcastle Disease:

1.	VaccinesIBA 03/28/2003 - "In ovo vaccination with a mixture of the recommended commercial doses of live APV and Newcastle disease (ND) vaccines had no detrimental affect on the efficacy of the APV vaccine. " 01/01/2003 - "The Ig-capture ELISA assay developed in this study can be useful for evaluating various strategies to improve the efficacy of Newcastle disease vaccines and to study the evoked immune mechanisms." 01/08/2010 - "The continuous outbreaks of fatal Newcastle disease (ND) in commercial poultry flocks demonstrate that current vaccination strategies are not fully efficacious and should be improved by new generation of vaccines. " 09/01/2008 - "Protective efficacy of commercial Newcastle disease vaccines against challenge of goose origin virulent Newcastle disease virus in geese." 03/01/2015 - "Development of an improved vaccine evaluation protocol to compare the efficacy of Newcastle disease vaccines."
2.	Hemagglutinins (Hemagglutinin)IBA 05/15/2015 - "Recombinant Newcastle disease viral vector expressing hemagglutinin or fusion of canine distemper virus is safe and immunogenic in minks." 12/01/2012 - "For the past decade, several recombinant Newcastle disease viruses (rNDV) have been used as a vector to express native or modified avian influenza (AI) hemagglutinins (HA) in order to give preventive protection against highly pathogenic avian influenza (HPAI) H5N1 viruses. " 06/01/2011 - "Efficacy of Newcastle disease virus recombinant expressing avian influenza virus H6 hemagglutinin against Newcastle disease and low pathogenic avian influenza in chickens and turkeys." 02/01/1950 - "The interrelationships of the cellular receptors and the hemagglutinin inhibitors of a new strain of virus (1233) to members of the mumps-Newcastle disease-influenza group have been investigated. " 10/01/1999 - "Four-week-old specific-pathogen-free white rock chickens were immunized with either a commercial recombinant fowl poxvirus-vectored Newcastle disease vaccine (FPN) expressing the hemagglutinin-neuraminidase and fusion protein genes of Newcastle disease virus (NDV) strain B1 or live NDV B1. "
3.	La Sota vaccineIBA 03/01/2015 - "In studies in SPF chickens, there were no negative impacts by the IBD V877 vaccine on the efficacy of a live QX-like IB vaccine and a live Newcastle disease La Sota vaccine in vaccination challenge studies, although the IBD vaccine had a negative effect on the antibody response generated by the QX-like IB vaccine. " 01/01/1985 - "Six experiments were carried out with aerosol immunization, using various doses of the La Sota vaccine against Newcastle disease, and a control infection with massive amounts of the viscerotropic virus strain Pavlikeni to evaluate the duration of carrying the Newcastle disease virus. " 01/19/1974 - "Vaccination against Newcastle disease with an inactivated oil emulsion vaccine at day-old followed by aerosol application of La Sota vaccine at three weeks." 01/01/1978 - "Effective in conferring solid immunity against Newcastle disease proved the combined application of the two vaccines in the following order: treatment of day-old chicks with a vaccine against Marek's disease and vaccination of the same chicks at the age of 8 days with a vaccine against Newcastle disease (strain B1) at a half rate, employing the spray method, followed by revaccination 15 days later with the La Sota vaccine at a full rate, employing the aerosol method."
4.	Neuraminidase (Sialidase)IBA 09/01/2001 - "Gene sequence analysis of fusion (F) gene cleavage motifs and haemagglutinin-neuraminidase (HN) carboxyl-terminal extension sequences was used to analyse Newcastle disease viruses (NDV) associated with virulent outbreaks of the disease which occurred in New South Wales, Australia in 1998-2000. " 07/04/2003 - "Correlation of haemagglutinin-neuraminidase and fusion protein content with protective antibody response after immunisation with inactivated Newcastle disease vaccines." 10/01/1999 - "Four-week-old specific-pathogen-free white rock chickens were immunized with either a commercial recombinant fowl poxvirus-vectored Newcastle disease vaccine (FPN) expressing the hemagglutinin-neuraminidase and fusion protein genes of Newcastle disease virus (NDV) strain B1 or live NDV B1. " 04/01/1998 - "The LOS-lectin binding was abolished when the LOSs were treated with Newcastle disease viral neuraminidase which cleaves alpha2-->3 linked sialic acid. " 07/01/1991 - "Vaccination against Newcastle disease with a recombinant baculovirus hemagglutinin-neuraminidase subunit vaccine."
5.	Inactivated VaccinesIBA 07/01/1986 - "Day-old broilers were administered live and/or inactivated vaccines to assess vaccine efficacy against challenge with Newcastle disease (ND) and infectious bursal disease (IBD). " 10/01/2001 - "It is concluded from the results of this study that fancy chickens can also successfully protected against Newcastle disease by using live and inactivated vaccines which are licensed for hybrid chickens. " 01/01/1988 - "[Production and trials of inactivated vaccines in oil excipient against Newcastle disease in Ethiopia]." 08/01/1994 - "Prophylactic vaccination against Newcastle disease using live and inactivated vaccines, as required by the fowl disease regulations, remains of great importance in maintaining health and productivity of the fowl. " 07/01/1986 - "Vaccination of day-old broiler chicks against Newcastle disease and infectious bursal disease using commercial live and/or inactivated vaccines."
6.	AntibodiesIBA 06/01/1990 - "Differences between the two study groups were evident: people having a known association with poultry showed significantly higher levels of antibodies to Newcastle disease and avian infectious bronchitis virus. " 11/01/1971 - "[Comparative studies on the development of hemagglutinating antibodies after vaccination against Newcastle disease with the strains La Sota and Hitschner B 1 and their tolerance in field trials]." 06/01/2015 - "Sero-monitoring was conducted in mass vaccination and control areas to assess the proportion of the target population with antibodies against HPAI and Newcastle disease (ND). " 02/01/2015 - "Enzyme linked immuno-sorbent assay (ELISA) test was used for the detection and quantification of antibodies to ND in the parent stocks and the chicks using IDEXX Newcastle Disease ELISA test kit. " 01/01/2014 - "Therefore, in investigating the diseases to which they are susceptible, serum samples from 56 francolins in a major live-bird market (LBM) in Ibadan, southwestern Nigeria, were screened for antibodies against Newcastle disease (ND) and infectious bursal disease (IBD) viruses. "
7.	AntigensIBA 07/01/2011 - "In this study, we have described the establishment of an antigen-specific T cell proliferation assay based on recall stimulation with Newcastle disease (ND) antigen; further, we have described the results obtained after recall stimulation of animals containing different major histocompatibility complex (MHC) haplotypes, vaccinated against ND. " 01/01/2012 - "One hypothesis is that the inactivation procedures used to inactivate the Newcastle disease antigen may alter the antigenic determinant recognised by the monoclonal antibody used. " 04/01/2006 - "At 47 d, four birds from each replicate (20/treatment) were injected with Newcastle disease (ND) antigen and blood samples were collected just before and 9 d after immunisation. " 01/01/1991 - "An enzyme-linked immunosorbent assay using a vaccine strain of Newcastle disease as antigen has been developed. " 01/01/1990 - "Newcastle disease HI titers were reduced significantly (P less than 0.05) from those of monovalent control vaccine groups when IBV antigen was emulsified in mixtures with low (1-3x) concentrated NDV or NDV and AIV antigens. "
8.	ChitosanIBA 01/01/2016 - "The inhibitory activity of the degraded chitosan for Newcastle disease was revealed by a hemagglutination test and RT-PCR. " 01/01/2016 - "Beta-chitosan extracted from Loligo Japonica for a potential use to inhibit Newcastle disease." 07/01/2012 - "In experiment 1, the results showed that the immune response, such as Newcastle disease antibody and CD4(+) T cells, would be significantly activated by feeding with chitosan and its derivative during 27 days. " 08/01/2007 - "[Study on immune efficacy of Newcastle disease chitosan microsphere vaccine]." 01/01/2016 - "Therefore, beta-chitosan has good development prospects during the development of veterinary drugs for Newcastle disease. "
9.	Liposomes (Liposome)IBA 01/01/2012 - "Preliminary evaluation of the immunoenhancement potential of Newcastle disease vaccine formulated as a cationic liposome." 05/01/2011 - "Span 20-based niosome was prepared by lipid film hydration technique and loaded with Newcastle disease vaccine. " 09/01/2013 - "The immunological adjuvant activity of gypenosides liposome against Newcastle disease vaccine." 12/06/2011 - "Immunological adjuvant efficacy of glycyrrhetinic acid liposome against Newcastle disease vaccine." 01/01/2012 - "This study evaluates the enhancement of immune response of birds to Newcastle disease (ND) vaccine encapsulated in 1,2-dioleoyl-3-trimethylammonium propane (DOTAP)-based liposomes. "
10.	SaponinsIBA 07/12/2011 - "Effect of oral administration of ginseng stem-and-leaf saponins (GSLS) on the immune responses to Newcastle disease vaccine in chickens." 10/15/2015 - "Improved immune responses to a bivalent vaccine of Newcastle disease and avian influenza in chickens by ginseng stem-leaf saponins." 07/12/2011 - "This study was designed to evaluate the effect of oral administration of ginseng stem-and-leaf saponin (GSLS) on immune responses in chickens vaccinated with live Newcastle disease (ND) vaccines. " 09/01/2011 - "Enhancement of humoral immune responses to inactivated Newcastle disease and avian influenza vaccines by oral administration of ginseng stem-and-leaf saponins in chickens."

Therapies and Procedures

1.	Microspheres (Microsphere) 05/01/2009 - "Multicolor quantum dot-encoded microspheres for the fluoroimmunoassays of chicken newcastle disease and goat pox virus." 03/01/2014 - "Development of a duplex Fluorescent Microsphere Immunoassay (FMIA) for the detection of antibody responses to influenza A and newcastle disease viruses." 08/01/2007 - "[Study on immune efficacy of Newcastle disease chitosan microsphere vaccine]." 05/01/2009 - "Two different antigens, Chicken newcastle disease (CND) antigen and goat pox virus (GPV) antigen, were conjugated to two kinds of biofunctional multicolor microspheres with different optical encoding. " 12/01/1953 - "Results of this procedure are compared with those of titrations based on egg infectivity and the polystyrene microsphere electron micrography for influenza virus; and with plaque count titrations on chick embryo cell monolayers in the case of the virus of Newcastle disease. "
2.	Oral Administration 08/01/1999 - "I. Oral administration of chicken interferon-alpha ameliorates Newcastle disease." 07/12/2011 - "Effect of oral administration of ginseng stem-and-leaf saponins (GSLS) on the immune responses to Newcastle disease vaccine in chickens." 07/12/2011 - "This study was designed to evaluate the effect of oral administration of ginseng stem-and-leaf saponin (GSLS) on immune responses in chickens vaccinated with live Newcastle disease (ND) vaccines. " 02/01/2013 - "Modulation of Humoral and Cell-Mediated Immunity Against Avian Influenza and Newcastle Disease Vaccines by Oral Administration of Salmonella enterica Serovar Typhimurium Expressing Chicken Interleukin-18." 09/01/2011 - "Enhancement of humoral immune responses to inactivated Newcastle disease and avian influenza vaccines by oral administration of ginseng stem-and-leaf saponins in chickens."
3.	Injections 03/01/1984 - "Chickens aged one or 21 days were given single injections of a vaccine against Marek's disease or Newcastle disease respectively, and monitored over a three week period for any signs of a stressor response. " 03/01/2011 - "Among those are mucosal vaccines for diarrheal diseases, hepatitis B and rabies; injectable vaccines for non-Hodgkin's lymphoma, H1N1 and H5N1 strains of influenza A virus, and Newcastle disease in poultry; and topical antibodies for the treatment of dental caries and HIV. " 07/01/1977 - "The adjuvant effect of the natural ds-RNA, BRL 5907, with inactivated Newcastle disease vaccines was confirmed using different oil-based formulations and could be given either as single injections or separately at adjacent sites. "
4.	Intramuscular Injections 10/01/2001 - "Four-day-old chicks were also treated with the same aerosol but after treatment with a Newcastle disease vaccine virus (NDVV) aerosol or intramuscular injection with methylprednisolon at day 1. The same E. " 12/01/2000 - "Effects of liquid paraffin on antibody responses and local adverse reactions after intramuscular injection of oil adjuvanted vaccines containing Newcastle disease (ND) and infectious bronchitis (IB) virus were investigated in chickens. "
5.	Aftercare (After-Treatment) 10/01/2001 - "Four-day-old chicks were also treated with the same aerosol but after treatment with a Newcastle disease vaccine virus (NDVV) aerosol or intramuscular injection with methylprednisolon at day 1. The same E. " 12/01/2011 - "In total, 540 one-day-old Cobb 500 broilers were randomly assigned to receive 1 of 5 (n = 108 birds/group) treatments: 1) no vaccination; 2) simplified vaccination, which included the infectious bronchitis vaccine (H120), the inactivated avian influenza vaccine (AI), the live vaccine strain Clone-30 of the Newcastle disease virus (NDV), and the combined inactive vaccine for infectious bursal diseases and the Newcastle disease vaccine (ND-IB); 3) normal vaccination (simplified vaccination + second dose of ND-IB, H120, and AI); 4) lipopolysaccharide (LPS) stress (normal vaccination+LPS); or 5) cyclophosphamide (CPM) stress (normal vaccination+CPM).The results showed that the average BW and average feed intake decreased significantly after treatment with LPS or CPM (P < 0.05). "